Karla Satchell's Avatar

Karla Satchell

@karlasatchell

Northwestern University Microbiology Professor studying Vibrio toxins, Structural Biology, COVID and RAS degraders. Supporting women as leaders in Science.

455
Followers
246
Following
26
Posts
22.01.2024
Joined
Posts Following

Latest posts by Karla Satchell @karlasatchell

We are on the move and this year will be held in beautiful Southbridge, Massachusetts at the height of leaf changing season. Conference is organized by toxin biologists for the toxin biology community. Come join us!

02.03.2026 19:38 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Conference banner showing trees with leafs changing colors.

Conference banner showing trees with leafs changing colors.

Announcing the 4th Lakeside Conference on Protein Toxins and Effectors 2026 Registration/Abstract Submission is OPEN (#lakesidePTE)! Come join this premier event on the structure, biochemistry, and cell biology of Microbial Protein Toxins Oct 12-15, 2026. event.fourwaves.com/lakesidepte2...

02.03.2026 19:38 πŸ‘ 5 πŸ” 5 πŸ’¬ 2 πŸ“Œ 0

I thought that was Nature group journals. Don’t you already work for that publication? Academics pay thousands and 10,000+ to publish in Nature publications. Can’t you just ask the editor one desk over?

20.02.2026 16:38 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Quote from Paper β€œThis trend raises questions about whether research papers can remain a reliable method for sharing scientific progress.”

15.02.2026 16:34 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Homepage | Yap Laboratory

🚨The Yap Lab at Northwestern Univ is looking to fill 2 postdoc positions in 2026 to study aspects of Staphylococcus aureus antibiotic resistance and RNA synthesis-degradation. Please contact Frances Yap at frances.yap@northwestern.edu for details. sites.northwestern.edu/yaplab/. Pls repost #Microsky

01.12.2025 16:45 πŸ‘ 13 πŸ” 21 πŸ’¬ 0 πŸ“Œ 0

Finally, I want to inform readers that my lab has been at the forefront for >15 years on understanding how these bacteria cause disease. However, we are struggling because, as a Northwestern Faculty member, my grants to study these infections have been frozen since March. Please Support Science!

25.08.2025 18:20 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Genetic Divergence of Vibrio vulnificus Clinical Isolates with Mild to Severe Outcomes | mBio Vibrio vulnificus is an aquatic pathogen that is capable of causing severe disease in humans. Previous studies have suggested that pathogenic isolates were restricted to certain phylogenetic lineages ...

Studies from my group have shown that Vibrio vulnficus bacteria from around the phylogenetic tree can cause infections in humans. So there are not good Vv and bad Vv...they are all bad. Just some may be much worse.
journals.asm.org/doi/10.1128/...

25.08.2025 18:20 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Preview
S3249 A Deadly Case of Vibrio vulnificus Bacteremia After... : Official journal of the American College of Gastroenterology | ACG An abstract is unavailable.

Vibrio vulnificus is also the leading cause of seafood-borne death. I love oysters...I recommend po' boys with fried oysters, grilled, and stews. But always cooked, especially in the warm months of the year. Shrimp and other seafood also can be sources of infection. journals.lww.com/ajg/fulltext...

25.08.2025 18:20 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Vibrio vulnificus septic shock due to a contaminated tattoo We present a case of Vibrio vulnificus septic shock and cellulitis in a patient with chronic liver disease that occurred after obtaining a leg tattoo with subsequent seawater exposure in the Gulf of Mexico. Initial suspicion for V. vulnificus was high and he was started on empiric doxycycline and ceftriaxone at admission. Blood and wound cultures grew oxidase positive and comma-shaped Gram-negative rods ultimately confirmed to be V. vulnificus. Despite aggressive initial treatment, the patient developed septic shock and died. This case highlights the association of chronic liver disease and high mortality associated with infections of V. vulnificus . Health providers should remain vigilant for V. vulnificus infections in patients with chronic liver disease and raw oyster ingestion or seawater exposure.

Caution should be taken when walking in brackish waters and swimming. Common clinical cases include cuts while fishing, walking in shallow waters with small cuts on feet, and this one of infection while swimming with a new tattoo. casereports.bmj.com/content/2017...

25.08.2025 18:20 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Preview
How to protect yourself from Vibrio vulnificus, the bacteria found in some coastal waters States are warning beachgoers about a summertime surge in infections from a frightening, flesh-eating bacteria found in coastal waters.

The annual news blitz about danger this time year of Vibrio vulnificus is upon us. If you live in the Gulf or Atlantic areas, and particularly if you have liver disease, cancer, or immunosuppression, Vv is a danger. The disease is rare but death rates high, survivors have long hospitalizations 🧡

25.08.2025 18:20 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 1

Great time with my awesome Northwestern colleagues at #GRCMAST

25.07.2025 04:16 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
A happy scientist holding a poster prize certificate

A happy scientist holding a poster prize certificate

Congratulations to Mason Clark who won the @fems MicroLife poster prize at the Microbial Adhesion and Signal Transduction GRC!

25.07.2025 02:47 πŸ‘ 33 πŸ” 5 πŸ’¬ 1 πŸ“Œ 1
Post image

Northwestern Micro representing at the 2025GRC MAST conference in beautiful Newport. Great science, collegial people but there’s a cloud hanging over us all. ☁️

24.07.2025 19:39 πŸ‘ 17 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1

β€œNIH will introduce a cap on allowable publication costs starting in Fiscal Year (FY) 2026, ensuring that publication fees remain reasonable across the research ecosystem. The policy aims to curb excessive APCs & ensure the broad dissemination of research findings w/o unnecessary financial barriers”

09.07.2025 14:02 πŸ‘ 15 πŸ” 7 πŸ’¬ 2 πŸ“Œ 0

This is an event on Tuesday in the House of Representatives hosted by the minority Science committee, led by @lofgren.house.gov.

Real question: why isn’t this being held in the evening and produced for TV and social media?

There are production and storytelling resources in Congress.

07.07.2025 15:42 πŸ‘ 50 πŸ” 19 πŸ’¬ 0 πŸ“Œ 0
Preview
Kennedy’s HHS Sent Congress β€˜Junk Science’ To Defend Vaccine Changes, Experts Say - KFF Health News A look inside the Department of Health and Human Services document citing vaccine misinformation that could influence congressional perceptions.

"A document [DHHS] sent to lawmakers to support Secretary Robert F. Kennedy Jr.’s decision to change U.S. policy on covid vaccines cites scientific studies that are unpublished or under dispute and mischaracterizes others."
kffhealthnews.org/news/article... via @kffhealthnews.org

15.06.2025 16:54 πŸ‘ 354 πŸ” 120 πŸ’¬ 18 πŸ“Œ 14
Preview
The MAHA Report Cites Studies That Don’t Exist The Trump administration’s β€œMake America Healthy Again” report misinterprets some studies and cites others that don’t exist, according to the listed authors.

RFK Jr's "MAHA" report is filled with references to studies that literally do not exist, or that completely misinterpret the studies' findings.

β€œWe did not publish a paper.. on this topic with that co-author group, or with that title,” says one cited researcher.

www.notus.org/health-scien...

29.05.2025 12:43 πŸ‘ 2123 πŸ” 966 πŸ’¬ 107 πŸ“Œ 233

Thanks to Northwestern Feinberg communications for writing this nice article on our recent work for the newsletter. @vibrio-vulnificus.bsky.social

11.05.2025 22:23 πŸ‘ 18 πŸ” 2 πŸ’¬ 2 πŸ“Œ 0

Great new study by my excellent colleague @jutraslab.bsky.social on treatments for Luke’s disease

28.04.2025 12:07 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

To say it once more today: I think you'll be moved if you take 2 minutes to look through 269 institutions signed on here.

Yes, still a few notable absences. (Where is Stanford?) But such an array of *presence.* Big and small. Public and private. World famous and barely known. Check them out.

23.04.2025 04:58 πŸ‘ 696 πŸ” 189 πŸ’¬ 52 πŸ“Œ 26
Post image

Graduate student Jiexi Chen presented today in the emerging scientist session #ASBMB25 on her new paper on toxin binding N-glycans. She did a great job!!

12.04.2025 23:20 πŸ‘ 12 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
Preview
Vibrio MARTX toxin binding of biantennary N-glycans at host cell surfaces The large pore-forming toxin MARTX with broad tissue tropism binds the essential unit of N-glycans on eukaryotic cell membranes.

Taking a break from the news in Bsky. Happy to share amazing study by student Jiexi Chen on Vibrio vulnificus MARTX toxin engagement of N-glycans and receptor L1CAM. First study on this toxin binding to cell surfaces. #vibrio #microsky #toxins www.science.org/doi/10.1126/...

11.04.2025 12:12 πŸ‘ 12 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Was great to participate in this project designed to test robustness of AI ligand prediction but had a side benefit of crowd-sourced discovery of a SARS-CoV-2 helicase inhibitor

11.03.2025 00:00 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Hi @schakowsky.house.gov The weather is supposed to be nice for @standupforscience.bsky.social Rally for Science on the National mall. I am coming from Evanston, hope to see my rep there too!!

06.03.2025 00:00 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Preview
How DOGE’s Cuts to the IRS Threaten to Cost More Than DOGE Will Ever Save The Trump administration claims gutting federal agencies will save money, but cutting the IRS means the government collects less taxes. β€œIf you’re interested in the deficit and curbing it, why would y...

Slashing IRS staff will end up costing the U.S. government.

Multiple studies have shown that for every dollar spent by the IRS, the agency returns between $5 and $12.

New @propublica.org by @andykroll.bsky.social

05.03.2025 11:25 πŸ‘ 919 πŸ” 283 πŸ’¬ 26 πŸ“Œ 16

They can use AI bots on their side to save time/cost to replace editors, and now trying to normalize this behavior to get reviewers to volunteer more often so they can grow revenue.

05.03.2025 13:02 πŸ‘ 5 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Nature is responding to a critical flaw in their business model, they need to grow revenue to keep billionaire investors on board, but depend on volunteer peer reviewers.
1/n

05.03.2025 13:02 πŸ‘ 18 πŸ” 2 πŸ’¬ 2 πŸ“Œ 0

Wonderful recognition! Hank gave great speech at ceremony on how service and faculty joining together is most important in challenging times

04.03.2025 16:57 πŸ‘ 9 πŸ” 2 πŸ’¬ 0 πŸ“Œ 2
Preview
Order out of Chaos | NEJM Eric Rubin comments on the effects of the raft of executive orders from the current administration on scientific research and public health.

www.nejm.org/doi/full/10....

03.03.2025 20:05 πŸ‘ 10 πŸ” 4 πŸ’¬ 0 πŸ“Œ 1
Preview
Stand up for Science Β· Indivisible Chicago Science is for everyone–and benefits everyone. When the federal government supports scientific research through taxpayer funding, it fuels innovation, creates jobs, and sustains the world we live in...

πŸ—½πŸ”¬ STAND UP FOR SCIENCE. Chicago joins the nationwide movement to demand that our government fully support scientific research, which employs people, benefits our economy, and SAVES LIVES

Join Indivisible Chicago & @standupforscience.bsky.social on Fri, March 7th, 12pm, Federal Plaza. Info/Sign-up:

26.02.2025 16:00 πŸ‘ 44 πŸ” 30 πŸ’¬ 0 πŸ“Œ 6