Leonard Van Gelder

Most tools use averages, or normal values, that really represent nothing about the individual using them. Not too mention they might be measuring the least important things. Companies aren’t invested enough in changing their algorithms or tools

Evolving an idionomic approach to processes of change: Towards a unified personalized science of human improvement The wide variety of “third wave” cognitive behavioral therapy (CBT) methods (e.g., Acceptance and Commitment Therapy or “ACT”, Compassion Focused Ther…

New form of stats introduced in psychology world:

www.sciencedirect.com/science/arti...

Agreed. Perhaps possibility of new idionomic approaches may help bridge the individual to group and group to individual friction. So much ground work to be laid to see. We’re doing our part 👷‍♂️👨‍💻

100% - broad reaches of a principle long known in physics but not getting enough attention elsewhere

Medical Benchmarks and the Myth of the Universal Patient From growth charts to anemia thresholds, clinical standards assume a single human prototype. Why are we still using one-size-fits-all health metrics?

Embracing the #nonergodicity of biology is the future of health.

#complexityscience #medicine

www.newyorker.com/magazine/202...

#physicaltherapy #rehabilitation #occupationaltherapy
contextualhealth.org/biggest-thre...

File under #nonergodicity

Millimetre-scale bioresorbable optoelectronic systems for electrotherapy - Nature A millimetre-scale bioresorbable optoelectronic system with an onboard power supply and a wireless, optical control mechanism is developed for general applications in electrotherapy and specific uses ...

Millimetre-scale bioresorbable optoelectronic systems for electrotherapy www.nature.com/articles/s41...

Suzetrigine, a Non-Opioid NaV1.8 Inhibitor With Broad Applicability for Moderate-to-Severe Acute Pain: A Phase 3 Single-Arm Study for Surgical or Non-Surgical Acute Pain Many patients experience inadequate pain control due to limited options that are both efficacious and safe for treating moderate-to-severe acute pain; therefore, opioids are still frequently prescr...

First phase 3 trial for the novel non-opioid drug Suzetrigine. It’s not placebo controlled and aimed to test the safety profile of the drug. I am not sure wheter this could be considered “well-tolerated” and “generally safe”

#physio
#painscience
#neuroskyence
🧪🛟

www.tandfonline.com/doi/full/10....

🚨 The paper is out! 🚨

If you work with movement, read this!
Human performance isn’t about optimizing parts. Rather, it is a continuous process of adaptation to ever-shifting constraints, both internal & external.

#movement #movementscience #sportscience #physio #physicaltherapy

shorturl.at/i59kC

Tendon pain - what are the mechanisms behind it? - PubMed Potential mechanism-based pharmacological treatment approaches could be developed by blocking promotors of nerve ingrowth, such as NGF, and promoting inhibitors of nerve ingrowth, like semaphorins, as...

Tendon tissue changes from loading may not matter much. Loading might help for other reasons—or just via movement variability reducing nociception. In the end, all pain ties back to changes in the nociceptive apparatus
#painscience #physicaltherapy #sportskyence
pubmed.ncbi.nlm.nih.gov/35850720/

“We instead observed substantial interindividual variability..”
#nonergodicity #humanhealth #medicine #painscience

Movement science has a problem: the myth of optimality. Sneak peek from Madhur Mangalam’s describing 60+ conflicting “optimal” states during the act of hiking. More coming soon. #physio #physicaltherapy #movementscience #sportsmedicine #complexityscience #sportscience

Absolutely love this image. We have to think bigger than the #brain.
#neuroscience #painscience #medicine

Since meaning (including Identity) derives from context, we have to take more than one viewpoint into consideration.

Even grammatically, we have to assign units to uncountable concepts, pointing to this paradox. Did those units exist before we created them?

What about the other direction? >

Platelet-Rich Plasma Injections are Inferior to Corticosteroid Injections for Short-Term Pain Relief: A Prospective, Double-Blinded, Randomized Controlled Trial We aimed to evaluate and compare the clinical benefits of platelet-rich plasma (PRP) injections compared to corticosteroid (CS) injections in patients…

How did we ditch basic biology for the illusion of #regenerativemedicine. #Regeneration doesn’t exist at a single level of biology, or even a few—and we can’t yet target the scope of #multilevelselection to make it real.
#medicine #painscience #complexityscience
www.sciencedirect.com/science/arti...

#multilevelselection in #pain - So much more for us to learn in the periphery and spinal cord!

𝗖𝗮𝗻 𝘄𝗲 𝗽𝗿𝗲𝗱𝗶𝗰𝘁 𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻?
Some aspects are well predicted, others are extremely difficult.
doi.org/10.1038/s415...

Not sure who all needs to hear this today but #complexityscience provides a little hope.

#physicaltherapy
#physiotherapy
#complexityscience
#neuroscience
#painscience

(PDF) AI-driven dynamic grouping for adaptive clinical trials: Rethinking randomization in precision medicine PDF | Integrating artificial intelligence into biomedical human subjects research is transforming traditional experimental paradigms. This review... | Find, read and cite all the research you need on ...

While historically, the RCT has had its place for scientific analysis, it has caused more problems than good in many contexts involving humans. Dynamic Grouping may better fit the non-ergodic nature of human problems.
www.researchgate.net/publication/...

#medicine #science #research

#multilevelselection

(PDF) Mechanical and cognitive postural instability drive shifts in whole-body coordination network PDF | Conventional human movement science often considers body parts and processes separately as belonging to complementary but distinct domains (motor... | Find, read and cite all the research you ne...

It is amazing to me how people still try & create these artificial constructs of an isolated movement system and outdated biomechanical concepts.
“Your body isn’t just moving -it’s networking” Madhur
#neuroscience #physio #movement

www.researchgate.net/publication/...

“Without that noise aspect, the model would fail,” Lynn said. “It wouldn’t produce anything that worked, which was surprising to us. It turns out you actually need to balance the Hebbian snowball effect with the randomness to get everything to look like real brains.”
#complexityscience #neuroscience

Emergent properties reveal how the brain transforms countless neural sparks into unified thoughts and emotions.

The same process drives creativity, where diverse ideas combine into something greater than the sum of their parts.

#neuroscience #creativity

Another level of #multilevelselection in the nociceptive apparatus!

#painscience #medicine #physio #evolution

Still early but some interesting possibilities #complexityscience #medicine #health #painscience

Love this multilevel perspective of barriers related to pain self-management

#painscience #behavior&evolution #physio #physiotherapy #meidince.

Reimagining Education: The Power of AI | Dr. James Hutson | #35 YouTube video by Madhur Mangalam

An essential listen on the future of education and AI’s impact on the workforce. Highlights include why shedding role-based identity is key in a rapidly changing world.

Another great interview from Madhur!

#education #science #work #ai #growth #evolution
m.youtube.com/watch?v=vFlj...

Are Tailored Interventions to Modifiable Psychosocial Risk Factors Effective in Reducing Pain Intensity and Disability in Low Back Pain? A Systematic Review With Meta-Analysis of Randomized Trials | Journal of Orthopaedic & Sports Physical Therapy OBJECTIVE: To determine whether tailored interventions based on patients' psychological profiles enhanced the outcomes of interventions in people with non-specific low back pain (NSLBP), compared to usual care. DESIGN: Systematic review with meta-analysis. LITERATURE SEARCH: Embase, Cochrane, Medline, Web of Science, CINAHL, and PsycINFO were searched from their inception until November 2, 2023. STUDY SELECTION CRITERIA: We included randomized clinical trials (RCTs) that compared psychological interventions to any alternatives without psychological components in patients with NSLBP who were stratified based on their psychological risk factors using the cutoff of the questionnaires measuring a psychological construct. DATA SYNTHESIS: The outcomes were pain intensity and disability. The revised Cochrane risk-of-bias tool for randomized trials was used to evaluate the risk of bias. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to judge certainty of evidence. RESULTS: Twenty-nine trials were included, most presenting some concerns for the risk of bias. The certainty of evidence was mostly low, with moderate to substantial heterogeneity. Using psychological stratification, individuals who received a psychological intervention (versus usual care) reported lower pain intensity at short (MD -0.22, 95% confidence interval [CI] -0.41, -0.02) and mid-term (MD -0.37, 95% CI -0.57, -0.16). For disability, there was a larger improvement with psychological interventions versus usual care at short- (SMD -0.17; 95% CI -0.32, -0.02), mid- (SMD -0.16; 95% CI -0.28, -0.05), and long-term (SMD -0.17; 95% CI -0.29, -0.04) follow-ups. CONCLUSIONS: Psychological interventions had a positive impact, although small, on reducing pain intensity and disability in patients with low back pain and psychological risk factors.

While this analysis doesn't account for #nonergodicity, relying on group-level assumptions that must later be compared to individual data. Still, it supports the need for individualized approaches in #chronicpain.
#physio #physicaltherapy #painscience #medicine

www.jospt.org/doi/abs/10.2...