@genesdev
G&D publishes high-quality research in molecular biology, cancer biology, development, neuroscience and related fields. In addition, G&D also publishes comprehensive Review Articles, Perspectives and Outlooks written by leading scientists.
CANCER METABOLISM REVIEW: Metabolic permissiveness: how tissue context shapes cancer
By Chrysanthi Moschandrea and Christian Frezza
➡️ https://genesdev.cshlp.org/content/40/5-6/287.full
Christian Frezza CECAD Cologne Universität zu Köln
#cancermetabolism #tumormicroenvironment
🚨 NEW ISSUE ALERT!!! 🚨
New Research articles and Outlook online now at Genes & Development.
Also in this issue, the first in a series of Review articles on Cancer Metabolism.
Click on the link to learn more:
➡️ https://genesdev.cshlp.org/content/40/5-6.toc
G&D Editor, Samantha Cyrill, is attending RNA Modifications: Bridging Biological Function & Therapeutic Potential next week in Keystone! #KSRNAMod26 Keystone Symposia
Happy to chat about your work and the journal. Stop by or reach out at cyrill@cshl.edu
For more info:
➡️ https://hubs.la/Q03-NnlC0
🆕 ADVANCE ONLINE 🆕
OUTLOOK: Making order from disorder in the nucleolus
By Susan J. Baserga @susanbaserga.bsky.social
➡️ https://genesdev.cshlp.org/content/early/2025/12/11/gad.353467.125.abstract
Also read:
➡️ https://genesdev.cshlp.org/content/early/2025/11/26/gad.353180.125.abstract
🆕 ADVANCE ONLINE 🆕
CANCER METABOLISM REVIEW: Metabolic permissiveness: how tissue context shapes cancer
By Chrysanthi Moschandrea and Christian Frezza
➡️ https://genesdev.cshlp.org/content/early/2026/02/09/gad.353516.125.abstract
#cancermetabolism #oncogene #tumorsuppressor #mutation #TCAcycle
🎙️ G&D Voices: Author and Editorial Board Member Maria-Elena Torres-Padilla 🎙️
At G&D, we aim to provide a thoughtful and supportive publishing experience.
Here’s what one author had to say about G&D's editorial process.
Learn more about publishing with G&D here:
➡️ https://genesdev.cshlp.org
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RESEARCH PAPER: Independent control of neurogenesis and dorsoventral patterning by NKX2-2
By Jang et al., and Hynek Wichterle
➡️ https://genesdev.cshlp.org/content/early/2026/01/12/gad.352886.125.abstract
#transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman
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RESEARCH PAPER: Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration
By Tracy, Chen and ZZ Zhao Zhang
➡️ https://genesdev.cshlp.org/content/early/2026/01/22/gad.353011.125.abstract
#retrotransposon #Drosophila #genomestability
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RESEARCH PAPER: Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state
By Zhang et al., and Alexander Tarakhovsky
➡️ https://genesdev.cshlp.org/content/early/2025/12/11/gad.353143.125.abstract
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RESEARCH PAPER: PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans
By Walker et al., and Oliver Hobert
➡️ https://genesdev.cshlp.org/content/early/2025/12/04/gad.353265.125.abstract
Columbia University HHMI
#Celegans #neuron #gut
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RESEARCH PAPER: Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli
By Meznad et al., and U. Thomas Meier
➡️ https://genesdev.cshlp.org/content/early/2025/11/26/gad.353180.125.abstract
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RESEARCH PAPER: Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief
By Islam et al., and Luca Busino
➡️ https://genesdev.cshlp.org/content/early/2025/12/08/gad.352916.125.abstract
#PROTAC #KRAS #cancer #cancertherapy
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RESEARCH PAPER: Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development
By Araoyinbo et al., and Aleksandar Vještica
➡️ https://ow.ly/99UX50Ye5KZ
Ayokunle Araoyinbo @vjesticalab.bsky.social
OUTLOOK: Flicking the switch for B cell development
By Ashley Ng and Stephen Nutt
➡️ https://genesdev.cshlp.org/content/40/3-4/143.full
Also read:
➡️ https://genesdev.cshlp.org/content/40/3-4/233.full
WEHI (The Walter and Eliza Hall Institute of Medical Research) University of Melbourne
#Bcell
RESEARCH PAPER: Potent synthetic lethality between PLK1 and EYA family inhibitors in tumors of the central and peripheral nervous systems
By Nelson et al., and Hilda Pickett
➡️ https://genesdev.cshlp.org/content/40/3-4/267.full
Children's Medical Research Institute
#cancertherapy #glioblastoma
RESEARCH PAPER: B-lineage commitment is dependent on a reversible epigenetic switch
By Tingvall-Gustafsson et al., and Mikael Sigvardsson
➡️ https://genesdev.cshlp.org/content/40/3-4/233.full
Linköping University @lunduniversity.bsky.social
#hematopoiesis #Bcell #transcriptionfactor #epigenetics
RESEARCH PAPER: Hunchback functions in the postmitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion
By Lee et al., and Chris Doe
➡️ https://genesdev.cshlp.org/content/40/3-4/255.abstract
HHMI University of Oregon
#neuron #drosophila #locomotion #hunchback
RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/40/3-4/215.full
Josh Mendell HHMI
#TDMD #RNAdecay #miRNA #triggerRNA #development
REVIEW: Nuclear receptor coregulator interactions: beyond the switch
By F. Nafrisha Cassim Bawa and Mitchell Lazar
➡️ https://genesdev.cshlp.org/content/40/3-4/146.full
University of Pennsylvania
#nuclearreceptor #transcription #ligand #coactivator #corepressor
RESEARCH PAPER: Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer
By Shao et al., and Maureen Murphy
➡️ https://genesdev.cshlp.org/content/40/3-4/199.full
The Wistar Institute
#ovariancancer #p53 #cancertherapy #endocrineresistance
G&D's Editor-In-Chief, Andrew Dillin, will be at the Keystone Symposia on Mitochondria Signaling in Physiology and Disease. #KSMitochondria26
If you’d like to chat about publishing your work with #genesdev, feel free to reach out to dillin@berkeley.edu
RESEARCH PAPER: SOX2 phosphorylation during mitosis limits genomic damage
By Williams et al., and Steven Pollard
➡️ https://genesdev.cshlp.org/content/40/3-4/185.full
Edinburgh University
#sox2 #chromatin #neural #mitosis #stemcells #phosphorylation
RESEARCH PAPER: ERRγ impedes neuroendocrine prostate cancer development
By Li et al., and Vincent Giguère
➡️ https://genesdev.cshlp.org/content/40/3-4/160.abstract
Vincent Giguère
#prostatecancer #neuroendocrine #cancertherapeutics #nuclearreceptor
🚨 NEW ISSUE ALERT!!! 🚨
New Outlook, Review, and Research articles online now at Genes & Development.
Click on the link to learn more:
➡️ https://genesdev.cshlp.org/content/40/3-4.toc
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Hunchback functions in the post-mitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion
By Lee et al., and Chris Doe
➡️ https://genesdev.cshlp.org/content/early/2025/11/20/gad.353223.125.abstract
#neuron #drosophila #locomotion
🎙️ G&D Voices: Author Lori Sussel 🎙️
From submission to publication, our authors’ experiences matter.
Here’s what one of our authors had to say about publishing with G&D.
Learn more about publishing with G&D here:
➡️ https://genesdev.cshlp.org
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Potent synthetic lethality between PLK1 and EYA family inhibitors in tumors of the central and peripheral nervous systems
By Nelson et al., and Hilda Pickett
➡️https://genesdev.cshlp.org/content/early/2025/11/20/gad.353271.125.abstract
#cancertherapy #glioblastoma
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: B-lineage commitment is dependent on a reversible epigenetic switch
By Tingvall-Gustafsson et al., and Mikael Sigvardsson
➡️ https://genesdev.cshlp.org/content/early/2025/11/20/gad.353002.125.abstract
#hematopoiesis #Bcell #transcriptionfactor #epigenetics
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.353138.125.abstract
Josh Mendell HHMI
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: SOX2 phosphorylation during mitosis limits genomic damage
By Williams et al., and Steven Pollard
➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.352664.125.abstract
#sox2 #chromatin #neural #mitosis #stemcells #phosphorylation