Does memory fade slowly, or in drops and bursts? We analyzed 728k tests from 210k people. Key finding: “stability” isn’t a trait you either have or don’t have - it’s often a time-limited state at different points in aging. Preprint "Punctuated Memory Change": 👇 www.biorxiv.org/content/10.6...
Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change www.nature.com/articles/s41...
Why do some people lose memory faster with age? A mega-analysis of 13 longitudinal datasets (3,700+ adults, 10,000+ MRIs) shows that memory decline tracks brain atrophy, especially in the hippocampus, and that these links strengthen with age, but not APOE status: www.nature.com/articles/s41...
Very impressed with @didacvp.bsky.social's work in @natcomms.nature.com, the most thorough mapping of longitudinal memory-atrophy relationships in normal aging, showing both global and memory-specific associations, which grow stronger with age. Early accsess here: www.nature.com/articles/s41...
Using 4570 longitudinal MRIs + 1684 Aβ PET scans from cognitively healthy older adults @jamesmroe.bsky.social find cortical thickness changed ≥7 years before PET-detectable Aβ. Those who later developed high Aβ already had thicker cortex & less thinning.
@LCBC_uio www.biorxiv.org/content/10.1...
@natmed.nature.com made a nice Research Briefing about our paper. Highglights with less details, the main conclusion is the same: Education does not affect memory decline or brain aging @LCBC_UiO @LifebrainEU www.nature.com/articles/s41...
New in @NatureMedicine Education is not linked to slower memory or brain decline in aging. We analyzed 400,000 memory tests and 15,000 MRIs from 33 countries. Associations likely shaped by childhood schooling and development. @LCBC_UiO @LifebrainEU rdcu.be/ex8iC
International study shows that higher levels of education do not reduce rates of cognitive and brain decline in later years, contrary to views that education protects against such decline: www.nature.com/articles/s41...
@rhens.bsky.social
Preprint: before age 60, between-people diffs in brain vols almost exclusively reflect stable diffs, while systematic diffs in rate-of-change in aging cause up to 40% of the variation to be due to change at 80 years. @edvardg.bsky.social 🧵https://www.biorxiv.org/content/10.1101/2025.05.26.655710v1
Very interesting from @VidalDidac - MUCH higher reliability for structural neuroimaging measures with longer follow-up time rather than more follow-ups or higher n. 2.-year follow-up requires 4 times higher n than 6-year follow up. @LCBC_UiO direct.mit.edu/imag/article...
Preprint from @didacvp.bsky.social - a common brain factor underlying memory decline in older age. Stronger associations in older, but independent of genetic Alzheimer risk. Very interesting work using >10.000 MRI scan. @LCBC_UiO www.biorxiv.org/content/10.1...
These findings suggest an intrinsic vulnerability of cognitive functions to structural changes in the aging brain, advocating for a multidimensional understanding of neurodegeneration in aging populations.
The results showed a nonlinear relationship between brain atrophy and memory performance in several cortical and sibcortical regions. Age strengthened the change-change associations but not APOE 4 status.
Check our latest: we mega-analysed 13 longitudinal studies, encompassing 3,737 adults and over 10,000 MRI scans, to explore the associations between structural brain changes and episodic memory decline with age and genetic predisposition (APOE 4 allele). 👇
www.biorxiv.org/content/10.1...
Preprint: Why is edu associated with better memory in aging? We used >400k memory tests & 15k brain MRIs: (1) Edu linearly related to memory, larger ICV & (slightly) larger vol in memory regions, (3) not less decline (mem+brain), (4) not enhanced tolerance to atrophy.🧵
medrxiv.org/cgi/content/...
