@geneontology
The Gene Ontology (GO, geneontology.org) knowledgebase is the world’s largest source of information on gene function. Our mission is to develop a comprehensive, computational model of biological systems, ranging from the molecular to organism level.
If you have more time and are looking for more of a foundational introduction to genAI (with lots of bio examples, and no maths) we are running a training series for members of the @geneontology.bsky.social consortium.
🚀January #GeneOntology release is here! Now covering 1.7M bioentities with 9.4M annotations across 5,500+ taxa✨
🔗 Get the data:
📊 current.geneontology.org
📁 doi.org/10.5281/zeno...
Details: community.alliancegenome.org/t/8613 via @alliancegenome.bsky.social
#Bioinformatics #OpenScience
Lots of #GeneOntology in this work as well! GO analysis showed enrichment of upregulated genes in pheromone signaling, cell wall biogenesis, cell shape regulation; downregulated genes associated with cell cycle progression, chromatin remodeling, histone gene expression, nucleosome organization
As a final nod to 2025, #GeneOntology announces our latest paper in @narjournal.bsky.social! Updates include expanded #Ontology & annotations in #Metabolism, multi-org interactions, #chromatin remodeling, & more.
Also ft. #Functionome v2 and 1500+ GO-CAM pathway models! 🧬🧪
doi.org/10.1093/nar/...
❄️ Gene Ontology Winter Break ❄️
Our resources will remain fully accessible through the holiday season: release.geneontology.org. Support requests will be addressed after we return on January 5th.
Wishing our wonderful community a restful season and a well-annotated 2026! 🧬✨
👏 Congratulations 🎉 to PhD student Daiqing Chen for her #PosterAward at @amsocmatbio.bsky.social for "The MatriGO Project: Systematic Curation and Refinement of ECM-related Terms in #GeneOntology" #UIC #MatrixBiology #Science
From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology:
“AI is showing how vital data curation really is.”
www.ebi.ac.uk/about/news/p...
🖥️🧬
Only a week until the next Alliance webinar, this month it will be on MicroPublications. Make sure you're registered now!
Gene functional profiles differ between large and miniature gobies. Dot plots of the top 10 enriched Gene Ontology (GO) terms and flow diagrams illustrating the genes involved in A) biological process in miniature species, B) molecular functions in miniature species, C) biological processes in large-bodied species, and D) molecular functions in large-bodied species. The x-axis displays the gene ratio (the proportion of input genes annotated to each term). Dot size represents the number of genes associated with each GO term, and dot color reflects the adjusted p-values. Categories unique to miniature or large-bodied species highlight differences in gene expression related to growth, development, and cell cycle regulation.
We identified many differentially expressed genes and found differences in gene ontology processes between groups. Genes involved in cell cycle regulation were enriched in miniature taxa, while genes associated with growth factors and tissue development were enriched in large-bodied gobies.
GONNECT: A Gene Ontology-guided Neural Network for Explainable Cancer Typing https://www.biorxiv.org/content/10.1101/2025.11.06.686983v1
Fig. 2. Venn diagram showing common as well as differentially expressed proteins under heat-stress, cold-stress, and optimal temperature conditions in Zygogramma bicolorata.
#LiteratureNotice Patel & Kumar. Functional complexity of Parthenium beetle, #Zygogramma bicolorata (Pallister) under thermal-stress conditions: Insights from Gene Ontology. doi.org/10.1016/j.as... #Beetle #Beetles #Mexicanbeetles #Calligrapha
It's #InternationalSnowLeopardDay. Check out GO's new October release for Unica unica #GOannotations, as well as over 9.4 million other annotations for other organisms!
More information about the release on the @alliancegenome.bsky.social Forums:
community.alliancegenome.org/t/8546
Reminder to everyone that's attending our in-person meeting next month- registration fees are due! Make your dinner choices and pay your meeting fees now. Check your email for both links!!
For anyone out there that might be hiring, we have absolutely loved working with @drglam.bsky.social and everyone at the Harvard FB and can't recommend them enough!
This is not only devastating to the staff directly affected, but also to the entire science community.
Did you register for the upcoming GOC meeting yet? Less than a month left to get the group rate on lodging! Details: community.alliancegenome.org/t/fall-2025-...
More release notes at community.alliancegenome.org/t/july-2025-...
@alliancegenome.bsky.social
New GO data just out!! The July 2025 GO Release 2025-07-22 is now available.
➡️ current.geneontology.org
➡️ release.geneontology.org/2025-07-22
📓 DOI 10.5281/zenodo.16423886: doi.org/10.5281/zeno...
39,906 GO terms
9,417,935 annotations
1,602,275 gene products
5,497 species
Already bored of summer? Not to worry, a new GO Release is here!
current.geneontology.org
release.geneontology.org/2025-06-01
10.5281/zenodo.15611813
40,122 GO terms
9,395,247 annotations
1,602,165 gene products
5,495 species
Photo of the fountain on Lake Geneva, taken by Tuyet Nguyen
It's started!
If you're not in Geneva right now you're missing out on the 2025 Spring GOC Meeting! If you've registered to attend remotely, please check your emails for links. Recordings will be available to GOC members and registered guests shortly after the meeting.
Updated preprint by Agneesh Barua agneeshbarua.bsky.social on convergence and pleiotropy in teleost fish gene evolution, with lots of new results!
www.biorxiv.org/content/10.1...
Last chance to register for the upcoming Spring GOC Meeting!
To all Consortium members, if you're planning on coming in-person to the meeting next month in Geneva, remember to register today! Check your email for the registration link, agenda, and hotel info.
You know about the PAN-GO #Functionome, but have you explored the power of the Functional Category search? Learn how to find #humangenes of interest in just a few clicks, using the Functional Categories
community.alliancegenome.org/t/8362
🧬🧪 #GOSlims
ICYMI: community.alliancegenome.org/t/8343
GIF of how to use the PAN-GO Functionome website to find functions for a specific human gene; stationary slides are available in the Alliance Forums linked in post
The PAN-GO #Functionome was announced last week in @nature.com-but do you know how to use it?
Here's how to find functions for a selected human #gene:
➡️ community.alliancegenome.org/t/8353
ICYMI, more on the PAN-GO Functionome:
💡 community.alliancegenome.org/t/8343
🧪🧬 #science #research #human
Immediately address any missing or incorrect functions!
Contact us to have information added, altered, or removed
To perform a GO enrichment, paste a list of genes here. You can even load our sample list to try it out immediately!
The functional categories displayed in the graph can be filtered by selecting one, two, or all (default) categories here
The number of genes in each high-level functional category is shown in this graph, which is hidden by default on some mobile devices
The functional characteristics
(GO annotations) of each gene are here, divided by functional category (GO subset):
* Molecular Function
* Biological Process
* Cellular Component
When you start, you’re looking at the list of all protein coding genes
short animation of the various features of the functionome.geneontology.org website
THE PAN-GO #FUNCTIONOME IS LIVE! Read our brand new #openaccess @nature.com paper and explore the PAN-GO Functionome, our most accurate and complete resource ever!
Paper links, press release, how to contribute and more on the @alliancegenome.bsky.social Forums: community.alliancegenome.org/t/8343
