BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis Ageing is characterised by persistent low-grade inflammation that is linked to impaired tissue homeostasis and functionality. However, the molecular mechanisms driving age-associated inflammation rema...

Hi Bluesky community:)

Our new manuscript is now available as a preprint!⛅️
biorxiv.org/content/10.1...

1/ Here, we describe a novel BMAL1-YAP complex in epidermal cells, which is hijacked during ageing to control the expression of up-regulated inflammation genes through enhancer binding.🧵

Amazing thread on out latest preprint!!! Kudos @juliabonjoch.bsky.social

Interested in lipid signaling... check out our latest paper for studying protein palmitoylation in mammalian cells. Great collaborative work between Fendt Lab (@kuleuvenuniversity.bsky.social) and Aznar-Benitah Lab (@irbbarcelona.org), led by Anke Vandekeere!!
authors.elsevier.com/a/1kZOH,25QI...