John Metzcar

Great opportunity for graduate students, post docs, and early career non-tenure track researchers to have their work elevated at #SMB2026 and #ECMTB2026!!

Thanks to the #MathOnco SMB subgroup for creating this opportunity!!

@smbmathbiology.bsky.social @mathonco.bsky.social

Congratulations to Mauro Cives, MD, a recipient of a 2025 NETRF Investigator Award for his work with Co-Investigator Anguraj Sadanandam, PhD, to advance immunotherapy for pancreatic neuroendocrine tumors (#PanNETs)!

Learn more ➡️ https://ow.ly/oWTS50YekyL

#NeuroendocrineCancer #NETRFGrants

It’s been great working with you all on this! Thanks for the opportunity!

The role of contact guidance and ECM remodelling in cancer invasion: a computational study The extracellular matrix (ECM) is a complex network of fibrous proteins and other macro-molecules that provides crucial mechanical and biochemical cues that regulate cancer cell invasion and tumour pr...

Congrats Margherita on completing her @physicell.bsky.social model investigating the effect of ECM organisation and remodelling and the interplay with chemotaxis on invasion www.biorxiv.org/content/10.1... Great collaboration with @jmetzcar.bsky.social , @mathcancer.bsky.social and Pradeep

He’s on the south west side of the station!

Be a part of ‪Endocrine Oncology's ‬special collection celebrating the contributions and leadership of women in Neuroendocrine Tumour (NET) research.
Original research, reviews and case reports all welcome!
🔗https://eo.bioscientifica.com/page/Women-in-NETs
Submit your proposal: eo@bioscientifica.com

Excited for this @cp-cell.bsky.social article co-led by @fertiglab.bsky.social and Genevieve Stein-O'Brien, on creating a plain language "grammar" to easily write simulation models as virtual laboratories for complex systems like cancer.

Fully open access and open source! 🧪 #mathonco #mathbio

A plain text modeling language—a cell behavior hypothesis grammar—to easily build virtual cell models and connect them to data, helping scientists to unlock the hidden dynamics of tissues @cellcellpress.bsky.social @mathcancer.bsky.social
www.cell.com/cell/fulltex...

New software simulates cancer cell behavior using genomics and computational models In the same vein as weather forecast models that predict developing storms, researchers have now developed a method to predict the cell activity in tissues over time. The new software combines genomic...

Fantastic work, @mathcancer.bsky.social ! phys.org/news/2025-07...

Due to early detection of #MultipleEndocrineNeoplasia type 2A (MEN2A), made possible by the genetic test, and the high chance of MTC, surgery to remove the thyroid gland is now done in children who carry the gene.
✅Get informed in 11 languages: incalliance.org/net-info-pac...
#LetsTalkAboutNETs

Optimal Approaches to Grading Entero-Pancreatic Neuroendocrine Tumors Using Ki-67 Proliferation Index (Hotspot and Whole Slide Digital Quantitative Analysis) Grading neuroendocrine tumors using Ki-67 PI is essential for prognostic assessment and therapeutic decision-making. However, the absence of standardized guidelines has led to methodological inconsist...

Time to rethink our approach to NET grading and use whole slide analysis (WSA) in addition to hotspot analysis (HSA) when assigning tumor grade using Ki-67? It certainly seems so.... @IHC_guy

www.modernpathology.org/article/S089...

American Association of Clinical Endocrinology Consensus Statement on Management of Multiple Endocrine Neoplasia Type 1 This document presents the findings of the American Association of Clinical Endocrinology (AACE) on the diagnosis, management, and surveillance of pat…

Wishing you had access to new and updated guidelines on MEN1...? Worry not, this team has you covered.

www.sciencedirect.com/science/arti...

BIRS Recap: Machine learning for model parameterization mathematical-oncology.org

Machine learning for model parameterization:
mathematical-oncology.org/blog/machine...

@hamiscalculated.bsky.social @jmetzcar.bsky.social @stolzbernadette.bsky.social
#MathOnco #MachineLearning

PRRT + PARP inhibitors in advanced NETs? To date, no trials have convincingly shown that PRRT + drug X (whatever that may be) is better than PRRT alone. The addition of PARPi seems to add little early toxicity but larger trials needed to show efficacy.

jnm.snmjournals.org/content/earl...

Oh - its so on! 💯 percent on!

Thanks to everyone for a fantastic meeting #SACB2025 @cancersysbio.bsky.social

(I sure needed an injection of great science in *these times*)

@mathcancer.bsky.social closing out the show...

So happy this is out for the community! Thanks to the journal for the opportunity to be in the early career special issue and to all my co-authors!

More than a dabble!!!

Improving #neuroendocrine #tumor treatments with mathematical modeling: lessons from other endocrine cancers
By John Metzcar et al. @kelines.bsky.social
Read it here 👉 https://doi.org/10.1530/EO-24-0025

It was a great team of contributors including three great undergraduate researchers!