Our recent journal club @jphysiol.bsky.social summarises the role of nitrate supplementation in improving age-associated neuromuscular outcomes. Congratulations to @jaydeepsharma.bsky.social , Ifrah, & Anamika. Sincere thanks to Prof.Tushar K Maiti & Prof. Sam J Mathew for their guidance.
A cochlea from a mouse ear after the tissue was transduced with an adeno-associated viral vector expressing green fluorescent protein. CREDIT: Jinan Li
A class of life-saving antibiotics called aminoglycosides can cause irreversible hearing loss by damaging inner ear hair cells. However, using CRISPR to inhibit the autophagy protein GABARAP prevented hearing loss in mice. In PNAS: www.pnas.org/doi/10.1073/...
Deletion of thrombospondin-1 prevents inflammaging and preserves blood stem cell fitness during aging
@scienceimmuno.bsky.social
www.science.org/doi/10.1126/...
3 reviews on planning, execution, & validation of transcriptomic experiments in neuroscience published in @natureportfolio.bsky.social #NatureNeuroscience.
A MUST READ if you're doing transcriptomics.
3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year!
(mini thread)
5th person to be cured of HIV
“Today, researchers announced the Dusseldorf patient still has no detectable virus in his body, even after stopping his HIV medication four years ago.”
Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance!
www.biorxiv.org/content/10.1...
Macrophages excite muscle spindles with glutamate to bolster locomotion
www.nature.com/articles/s41...
