Schiracha (Schirra, but a little spicy)

I'm really excited about this meeting on epigenetic editing!

It was great to see you speak in person and not just read your thoughtful and extremely helpful insights on discussion forums and social media. These small proteins always intrigued me. I am always pushing how picking and parameters can really affect workflows and capitalizing on your priors.

@olibclarke.bsky.social at #ASBMB. the fan feels were real. The room was captivated in a noticeable way and the question line was quick to fill and it was as much a help hotline as it was a q/a line. Beautiful 🤌

Can we think of Molecular lattice as a population growth model under strain where the birth rate is the on rate and the death rate is the off rate and the maximum population is proportional to the strain on the system. We would need a logistical map based on seed areas for growth.

All together now, "Unfavorable does not mean unstable."
Thank you. That is all
#biosky

Here you can see a Cryo-EM structure of the flotillin-associated rhodopsin PsFAR in detergent micelle (PDB code: 9R21)

Rendering by Francisco J. Enguita made with #ProteinImager

3dproteinimaging.com/protein-imag...

#SciArt #molecularart #micelle #flotillin #bacteria #cryoem

"These were good people"... "patriots"

Happy Feet Close To The Edge GIF ALT: Happy Feet Close To The Edge GIF

Every postdoc I know right now

⏰ Next week!

@aliboyle.bsky.social
@thebsps.bsky.social
@vanessaseifert.bsky.social

#PhilSci #Philosophy #Popper

There's an etiquette in science that is simply lost on so many, including PIs and its getting so much worse. I have no patience for intolerant old persons being dicks just because they are professionally untouchable. There's a lot of good people out there still, but there's a lot of bad too.

The key to processing cryoEM is to capitalize on your priors. People will tell you to un-bias your science. You cant remove bias from science. What you can do is limit and control negative bias while capitalizing on positive bias. Knowing and utilizing priors, having proper controls is good science

Regulated cell death in fungi from a comparative immunology perspective - Cell Death & Differentiation Cell Death & Differentiation - Regulated cell death in fungi from a comparative immunology perspective

The fungal immune system runs on the same protein families as your innate immunity: NLR sensors, TIR signaling, gasdermin pore-formers. The pathways cluster in 2-3 gene operons, echoing bacterial defense islands. Billion-year-old toolkit, still in production.

🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...

The first ten years of the CCP-EM Spring Symposium, an annual conference to bring together the cryoEM community to present and discuss the latest methodological advances and applications, are described #Cryoem #ElectronCryoMicroscopy #CCPEM doi.org/10.1107/S205...

Very happy to share a new preprint from the Vannini Lab @alessandrovannini.bsky.social at @humantechnopole.bsky.social. www.biorxiv.org/content/10.6...
If you are curious to understand what are the conformational changes that make condensin II able to compact the DNA during mitosis, have a read!

Do molecules have structure? The view from quantum physics | Vanessa Seifert and Alexander Franklin 6.30pm Wed 25 Feb | Vanessa Seifert, Alexander Franklin | Ticket Required | Free public event at LSE

We are delighted to invite you all to the inaugural BJPS Popper Prize Lecture on Wednesday 25 February 2026 6.30-8pm. To be delivered by the 2024 BJPS Popper Prize winners, Alex Franklin and Vanessa Seifert. This hybrid event will be hosted by LSE. Please register here: www.lse.ac.uk/events/molec...

Bipartite network of ncORF-CDS co-translation in mice

🧬 A major data reanalysis in December's most-read Genetics paper uncovers thousands of previously hidden protein-coding regions in human and mouse genomes: buff.ly/6TsX3ct

JCS cover showing two cells side-by-side, one with a dispersed Golgi (pink) and another with a compact Golgi. Actin is shown in yellow and the nuclei in turquoise.

Issue 2 is complete

Explore our ToC: journals.biologists.com/jcs/issue/13...

Our cover image shows differential Golgi phenotypes in breast cancer cells. The relative distribution of the Golgi is mechanoresponsive. See article by Saha, et al.
journals.biologists.com/jcs/article/...

a woman with red hair says ain 't it fun ALT: a woman with red hair says ain 't it fun

You aren't willing to advocate for yourself, no one else fucking will.

The real skill is turning that comment into a question.

Pre-ACA, I was a postdoc on an NSF fellowship at a university that didn't offer employment benefits to independent fellows. At that time, being a woman meant that my premiums were double that of my male counterparts. The extra cost came out of my grant's budget for benefits, equipment, and travel.

There's always a new low.

Which is bad in itself, and says bad things about the US government. It also reveals more bad people who are willing to just follow orders, and help bad government do bad things.

I have finally found a way to gid rid of the discover bar on the Amazon Kids profile on my child's fire tablet. Just in time for traveling

Evolution is a balance of whatever works with whatever shows up first and not what wins, but what succeeds enough..
C's get degrees kind of approach
What doesn't kill you makes you.... still (painfully) alive .. and will probably persist for quite a while

We're told ion high school and college biology that proteins are hyper specific and have exact mechanisms, substrates, and products. It becomes so difficult to make someone an expert that understands biology is complex, proteins are promiscuous and EVOLUTION IS NOT OPTIMIZATION

Eulers formula is for crystalline solids. Proteins are more plastic than crystal.
One small push from mankind, one giant shift in assembly geometry.
www.mdpi.com/1999-4915/16...
Others have shown compensatory mutes can save this nearly (but not completely) dead virus.

Micheal Rossman was chastised at CSH for pushing the octahedral hypothesis but now we have viruses that utilize this geometry in some aspect of their structure.
Its also possible that retroviruses utilize non-geodesic facets as a sort of off path mechanism to close -investigations ongoing

Eulers formula may be ideal but isn't the only way to make a closed shells. My thesis goes into more depth. Also thsi geodesic idealism was originally realized with octahedrals in mind and several viruses have been shown to use octahedral geometry
www.mdpi.com/1999-4915/16...