Surojit Sural

Bacterial pyruvate metabolism regulates host insulin sensitivity in C. elegans https://www.biorxiv.org/content/10.64898/2026.03.04.709558v1

All-optical analysis of electrical coupling in muscle ensembles reveals contributions of individual innexins to cell synchronizationand locomotion https://www.biorxiv.org/content/10.64898/2026.03.03.709215v1

Gas-sensing neurons prime mitochondrial fitness to offset metabolic stress | PNAS The mitochondrial unfolded protein response (UPRmt) is triggered by cells to alleviate proteotoxicity in response to metabolic stress. The ability ...

I'm excited to share our PNAS paper from 1st author Rebecca Cornell. We reveal that preemptive enhancement of stress responses can be triggered to combat metabolic challenges.

Gas-sensing neurons prime mitochondrial fitness to offset metabolic stress | PNAS www.pnas.org/doi/10.1073/...

How a Single Neuron Controls Social Swarming in Worms - BioPatrika Researcher Spotlight - how serotonin and PDF-1 signaling balance drives swarm-like social behavior in C. elegans, revealing how single-neuron modulation can reshape collective behavior.

#researcherspotlight Dr. Navneet Shahi @navneetshahi.bsky.social from Prof, Kavita Babu lab @kavita-babu.bsky.social at IISc Bangalore talks about her work on "How a Single Neuron Controls Social Swarming in Worms" #CNSIISc biopatrika.com/academia/res... via @biopatrika.bsky.social

HazardPyMatch: A tool for identifying reproductive and other hazards in scientific laboratories Parker et al. present HazardPyMatch, an automated tool that identifies hazardous chemicals such as reproductive hazards using standardized classifications and adaptable search criteria. This workflow ...

HazardPyMatch: A tool for identifying reproductive and other hazards in scientific laboratories

www.cell.com/cell-reports...

Neuromodulation of swarming behavior in Caenorhabditis elegans: Insights into the conserved role of calsyntenins | PNAS Collective animal behaviors arise from a complex interplay between internal physiological states and external environmental cues. In Caenorhabditis...

Very cool work by Navneet on collective behaviour in worms now out in @pnas.org. Congratulations to all the authors Nisha, Sharveri, Dimple and collaborators Sarıtekin and Aşkın Kocabaş. We show that calsyntenin mutants in C. elegans show a collective swarming behaviour. www.pnas.org/doi/10.1073/...

Ribonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules Kim et al. identify RNK-1/RNASEK as a conserved ribonuclease that degrades age-dependently increased circular RNAs. The loss of RNASEK leads to stress-granule persistence and accelerates aging, suppor...

Ribonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules

www.cell.com/molecular-ce...

We are 30 today!! 🎂🎈🎉
30 yrs of scientific ups and downs, exciting new findings and totally wrong hypotheses, fundable scores and not, and the privilege of working with all the many people who joined our adventures in the wormverse.
Can’t wait to see everyone again at our lab reunion this summer!

Intestinal pathogens override hunger-driven decision-making via immune regulation of central serotonin signaling in C. elegans

www.nature.com/articles/s41...

Modulation of the RNAse P/MRP complex and mitochondrial ribosome enhances cytosolic ribosome coordination and sustains longevity https://www.biorxiv.org/content/10.64898/2026.02.23.707525v1

Crash Course Scientific Thinking Crash Course Scientific Thinking |

Crash Course Scientific Thinking Video Series

www.biointeractive.org/crash-course...

Non-visual light modulates behavioral memory and gene expression in Caenorhabditis elegans Visible light engages a non-visual, bZIP-dependent transcriptional pathway in peripheral tissues that communicates with the nervous system to shape behavioral plasticity and memory, enabling optogenet...

Non-visual light modulates behavioral memory and gene expression in Caenorhabditis elegans

elifesciences.org/articles/108...

Sex-specific differences in mediobasal hypothalamus in response to nutritional states

www.nature.com/articles/s41...

Transcriptomic and chromatin accessibility profiling unveils new regulators of heat hormesis in Caenorhabditis elegans

journals.plos.org/plosbiology/...

SIRT6 Regulates Protein Synthesis and Folding Through Nucleolar Remodeling SIRT6 regulates proteostasis through nucleolar regulation. SIRT6 regulates (A) pre-rRNA editing through nucleolar factors, as well as (B) rRNA transcription through TIP5 – and thus the NoRC – chromat...

Beautiful work that used C. elegans and mouse models, cell lines and human patient samples to address a complex question in aging research, which spans biochemistry, cell biology and organismal physiology.

onlinelibrary.wiley.com/doi/10.1111/...

Efficient pheromone navigation via antagonistic detectors in Caenorhabditis elegans male

www.nature.com/articles/s41...

Glycolytic Specialization Shapes Neuronal Physiology and Function in vivo https://www.biorxiv.org/content/10.64898/2026.02.17.706437v1

The mitochondrial chaperone HSPD1 folds MTHFD2 independently of its co-chaperone HSPE1 https://www.biorxiv.org/content/10.64898/2026.02.16.706072v1

Caenorhabditis elegans avoids Todstoff, a novel nociceptive necrotaxis cue https://www.biorxiv.org/content/10.64898/2026.02.06.704436v1

Exposure to deceased remains of conspecifics extends the lifespan of young and aged C. elegans via distinct pathways https://www.biorxiv.org/content/10.64898/2026.02.08.704602v1

CUT homeobox factors modulate chromatin accessibility in neurons https://www.biorxiv.org/content/10.64898/2026.02.10.705137v1

Molecular insights into diverse heat hormesis regimens in Caenorhabditis elegans Abstract. Heat hormesis describes a biphasic, dose-dependent response in which low levels of heat stress induce beneficial effects, such as enhanced lifesp

Molecular insights into diverse heat hormesis regimens in Caenorhabditis elegans

academic.oup.com/genetics/adv...

Mild Mitochondrial Impairment Activates Overlapping Longevity Pathways Converging on the Flavin-Containing Monooxygenase FMO-2 https://www.biorxiv.org/content/10.64898/2026.02.10.705198v1

ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

ER remodelling is a feature of ageing and depends on ER-phagy
www.nature.com/articles/s41...

Distinct Molecular Mechanisms Regulate Feeding State-Dependent CO2 Chemotaxis Plasticity During Different Life Stages in Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.02.06.704338v1

A pilot study for whole proteome tagging in C. elegans https://www.biorxiv.org/content/10.64898/2026.02.09.704846v1

Epitope-based labeling for improved live-imaging of endogenous proteins in C. elegans https://www.biorxiv.org/content/10.64898/2026.02.05.703904v1

Cell-specific roles for the conserved Galpha chaperone RIC-8 in cilia biology https://www.biorxiv.org/content/10.64898/2026.02.07.704597v1

Improved Dye-Filling Protocol for Multiple Nematode Species

www.micropublication.org/journals/bio...

I've always been a fan of what the Allen Institute is doing. New in Nature: OpenScholar, an 8B RAG model for scientific literature, outperforms GPT-4o by 6% on correctness. Experts preferred its answers over human-written ones 51%-70 of the time. www.nature.com/articles/s41... 1/3 🧵