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Karin Schann

@karin555

Scientist at the CNB-CSIC Madrid SynBio enthusiast 🧬🦠 Microbial engineering | Synthetic metabolism | Biosensors Berlin πŸ‡©πŸ‡ͺ | Madrid πŸ‡ͺπŸ‡Έ | Groningen πŸ‡³πŸ‡±

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12.11.2024
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Latest posts by Karin Schann @karin555

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We are offering a #PhD candidate position (Spanish FPI) to work with us at the @cnb-csic.bsky.social in Madrid. The project you would be part of: establish a #biofoundry at our institution, to optimize #synbio experiments from #design to #test. If interested, get in touch!

30.05.2025 07:22 πŸ‘ 8 πŸ” 9 πŸ’¬ 0 πŸ“Œ 1
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Excited to share a main project from my PhD, out now in
@naturecomms.bsky.social! πŸ“
We've designed and brought to life the β€œCORE cycle” – a new-to-nature pathway that provides a novel route for biological CO2 capture 🦠🌱
nature.com/articles/s41...
Take a look! Thread below... 🧡

04.04.2025 10:03 πŸ‘ 39 πŸ” 17 πŸ’¬ 4 πŸ“Œ 4
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Interested in Sustainability, Metabolic Engineering and Evolution?
Check out how we convinced E. coli to grow on the CO2-derived substrate formic acid using the synthetic Serine Threonine Cycle! β™»οΈπŸŒ±πŸ¦ 

OPEN ACCESS publication to be found here:
🚨 doi.org/10.1016/j.ym... 🚨

#MEvoSky #microsky

(1/🧡)

06.03.2025 10:11 πŸ‘ 37 πŸ” 14 πŸ’¬ 2 πŸ“Œ 2
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Computation-aided designs enable developing auxotrophic metabolic sensors for wide-range glyoxylate and glycolate detection - Nature Communications Auxotrophic metabolic sensors (AMS) are vital for bioengineering but are often time-consuming to develop. Here, the authors present a workflow for designing versatile AMS, demonstrating their use for ...

Really happy to share that our work on constructing six glyoxylate / glycolate sensors covering a three order of magnitude concentration range is out now in Nature Communications ! πŸ”₯

Read below to see how we developed the sensors and what they are good for πŸ₯³.

www.nature.com/articles/s41...

04.03.2025 18:03 πŸ‘ 8 πŸ” 4 πŸ’¬ 1 πŸ“Œ 1
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Hello Bluesky community,
transitioning from passive observer to active participant on this platform, I want to quickly introduce myself:

I am a synthetic biologist with a passion for enzymes and metabolic pathways that enable microbial growth on CO2/CO2-derived carbon sources.

14.02.2025 12:38 πŸ‘ 30 πŸ” 8 πŸ’¬ 2 πŸ“Œ 0
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Some of the 🚫πŸͺžπŸ¦  authors got grants to do exactly this. We've discussed pros & cons of this by now, but the grant text actually is a great example of how blatantly we exaggerate in proposals. In 2019, they propose to create mirror cells within 6 yrs. In 2024, they write such a feat is far away. 1/2

15.12.2024 09:04 πŸ‘ 7 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

Such a special day with these amazing people! Feeling so grateful for all the memories and the wonderful time spend together. I'll miss working with you! πŸ«ΆπŸΌπŸ§¬πŸ¦‹

12.12.2024 19:09 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Thank you for such a wonderful farewell! It’s been amazing working with this incredible team - Os voy a echar de menos!

12.12.2024 19:03 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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πŸ’₯πŸ’₯πŸ’₯ !!! Please re-post !!! πŸ’₯πŸ’₯πŸ’₯

Hello Community,

We’re excited to announce that we’re moving to Groningen in January 2025 to embark on a new chapter in our research careers. For this, we need a house/flat and we hope to find a nice place with your help.

09.12.2024 15:20 πŸ‘ 11 πŸ” 8 πŸ’¬ 1 πŸ“Œ 0
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We developed a brand new #CRISPR toolkit for Cupriavidus necator, a biotechnological platform for CO2 (and derivatives) valorization.

The system is based on self-splicing introns and allows us to get mutants within 48h and with efficiencies up to 80%

doi.org/10.1101/2024.11.24.625072 [1/n]

25.11.2024 13:58 πŸ‘ 16 πŸ” 8 πŸ’¬ 3 πŸ“Œ 0
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Streamlined and efficient genome editing in Cupriavidus necator H16 using an optimised SIBR-Cas system Cupriavidus necator H16 is a promising microbial platform strain for CO2 valorisation. While C. necator is amenable to genome editing, existing tools are often inefficient or rely on lengthy protocols...

My first paper post on BlueSky: today our preprint on an an efficient SIBR-Cas tool for genome editing of my favorite C. necator (bug growing on H2, CO2 and formate came online www.biorxiv.org/content/10.1... #syntheticbiology #C1

25.11.2024 17:47 πŸ‘ 11 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

EMBL Sabbatical Visitor fellowship offers senior scientists an opportunity to spend up to 1 year at EMBL, fostering collaboration, research exchange and exploring new fields in a vibrant and interdisciplinary environment! The sabbaticals are funded up to 15 000 ,- €.

25.11.2024 08:56 πŸ‘ 4 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0