We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social π (1/3) www.nature.com/articles/s41...
π¨Our work on the impact of DNA replication on 3D genome is out in Genome Biology: replication-dependent loop extrusion by sister-forks, wave of replication, no evidence for large-scale replication factory. Great collab with @aurelepiazza.bsky.social. More here: link.springer.com/article/10.1...
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5β²β3β² direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm!
www.nature.com/articles/s41...
4οΈβ£ Featuring the fourth of our showcase projects
Upgrading GROMACS to handle billion-atom systems and enhancing I/O performance and precision, making the first-ever whole-cell simulation possible β‘οΈ bioexcel.eu/uw67
#MolecularDynamics #GROMACS #ComputationalBiology
π¨New preprint from the labπ¨
𧬠What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
Extensive differences observed in 3D genome structure between homologous heterozygous chromosomes revealed by Genome Architecture Mapping #GAM in the @apombo1.bsky.social lab β‘οΈ www.embopress.org/doi/full/10....
Glad to share our latest publication in Nature Genetics: Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. In this work, we generated the first single-cell 3D genome atlases of any cancer using any technique. 1/12
What better way to launch our new account with the publication of @jmstein.bsky.social latest paper from the lab! π§ͺ Check out the 𧡠below to learn more about tkPAINT and how we use it to image proteins, DNA, and RNA in the nucleus using DNA-PAINT.
Our new preprint is out on bioRxiv! We show that restoring rigidity sensing via Tpm2.1 is not enough to trigger anoikis in cancer cells, thanks to compensatory AKT signaling and cellβcell adhesion.
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
Caption+Credit: EMBLβs AI Strategy aims to transform life sciences by integrating AI across research areas like genomics, drug discovery, and imaging. Creative team/ EMBL
π EMBLβs new initiative is set to transform life science research through full AI integration β from genomics to drug discovery.
π‘ Funding from the Hector Foundation is dedicated to attracting interdisciplinary talent, boosting infrastructure, training, & innovation.
www.embl.org/news/connect...
To all post-docs: The Genome Biology dept βͺ@embl.org
has an Independent faculty position. Fantastic place to set up your lab βgreat package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Are you @ the late stages of your postdoc ? Want to pursue a PI career ?
Then this ππ is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!!
Please distribute :) π
New from the Dai and Li labs: Meta-learning-empowered reflective lattice light-sheet virtual structured illumination microscopy (Meta-rLLS-VSIM) offers near-isotropic resolution for fast and versatile super-resolution imaging of subcellular dynamics www.nature.com/articles/s41...
Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis
π§¬π©Έ screen of fully synthetic enhancers in blood progenitors
π€ AI that creates new cell state specific enhancers
π negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
π§΅
Check this out! ππ»ππ»
Amazing work on regulatory element evolution .. Bravo to all involved @arnausebe.bsky.social @mamartirenom.bsky.social but
expecially @ianakim.bsky.social β¦ she is a star ππ»ππ»
Perturb-tracing integrates CRISPR screening with barcode readout and chromatin tracing for loss-of-function screens, facilitating the study of chromatin folding regulators.
www.nature.com/articles/s41...
Read the News & Views highlighting this cool work here!
www.nature.com/articles/s41...
Bravo to all !! Definitely in my reading list for the weekend !!
Excited to share our latest work on how cells fold their genomes, and build mitotic chromosomes! Out in Science today!
Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes!
With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs.
See thread below:
Looking for a PhD in sunny Barcelona? βοΈπ¬
Our team is hiring a PhD student for the @hologen.bsky.social
project!
π
Deadline: *Apr 20*
β οΈ READ THE MOBILITY RULE FOR THIS POSITION
π Please, spread the word
All the info here π www.cnag.eu/jobs/phd-stu...
#PhDlife #Genomics #HoloGen #Barcelona
Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. π§¬
But did you know they can also jump π£π¦π΅πΈπ¦π¦π― cells? π€―
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread π§΅π
gracias Marc :)
Just apply! Amazing Lab βΊοΈ
Looking for a PhD in sunny Barcelona? βοΈπ¬
Our team is hiring a PhD student for the @hologen.bsky.social project!
π
Deadline: Apr 20
β οΈ READ THE MOBILITY RULE FOR THIS POSITION
π Please, spread the word
All the info here π www.cnag.eu/jobs/phd-stu...
#PhDlife #Genomics #HoloGen #Barcelona
Celebrating 10 years of our lab with a new preprint:
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana TΓΌnnermann and modelling by Gregory Roth
It's Day 2 of #EMBLAIOneHealth! π
Today, participants heard a keynote from Giorgio Metta (Italian Institute of Technology (IIT), Italy) on artificial intelligence in RNA interactions, disease prediction, and therapeutic design.
π· EMBL Photolab: Stuart Ingham
𧬠Weβre hiring a Postdoc in Genomic Data Science @IITalk! Join us to explore 3D genome architecture and RNAs using imaging, genomics & ML π»π¬π
πΌ Up to β¬45k/year
β
PhD + Python/ML skills
β Experience with omics, imaging, or modelling = plus
π Genoa πβοΈ
π§ irene.farabella@iit.it
π tinyurl.com/6z52jhr9
π¨π¨ MEGA JOB ALERT π¨π¨
Independent Group Leader Positions in Computational Biology @humantechnopole.bsky.social!
Are you ready to start your own lab? Do you know someone who is? Repost this + share with everyone who might want to know about it. Thanks!!! π
More details below... check it out! 𧡠1/3
