Niklas Joisten

@niklasjoisten.bsky.social @sebproschinger.bsky.social @50823zimmer.bsky.social

Looking forward to 2026!

Full article: doi.org/10.1038/s414...

How to stop the revolving door of German academia Germany is one of the most popular destinations for students and scholars worldwide, but those pursuing academic careers face significant hurdles to success.

Germany is one of the most popular destinations for students and scholars worldwide, but those pursuing academic careers face significant hurdles to success

www.nature.com/articles/d41...

Immunological Protein Signature During Acute Exercise Click on the article title to read more.

Very happy to see our report on the kinetics of 92 immunological proteins measured in blood serum during acute aerobic exercise now out in Acta Physiologica! Fascinating how many immunological factors are influenced by a single bout of exercise 👇

onlinelibrary.wiley.com/doi/10.1111/...

Persons With Multiple Sclerosis Reveal Distinct Kynurenine Pathway Metabolite Patterns | Neurology Neuroimmunology & Neuroinflammation Background and ObjectivesKynurenine pathway (KP) metabolites modulate inflammatory activity and neuronal viability. The consequences of KP imbalance partly resemble the molecular mechanisms of multipl...

In this fantastic collaborative project with colleagues from Norway, @tu-dortmund.bsky.social @au.dk @uni-saarland.de, our outstanding PhD student @mkupjetz.bsky.social has shed light on distinct kynurenine pathway patterns in persons with #multiplesclerosis.

www.neurology.org/doi/10.1212/...

Systematic profiling reveals betaine as an exercise mimetic for geroprotection Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

Systematic profiling reveals betaine as an exercise mimetic for geroprotection: Cell www.cell.com/cell/fulltex...

Late breaking at #ASCO25:

A 3-year structured exercise program after adjuvant chemotherapy for colon cancer improved disease-free and overall survival, physical functioning, and fitness, as compared with health education alone. Full CHALLENGE phase 3 trial: nej.md/4mh5RPL

@ascocancer.bsky.social

Exercise training restores longevity‐associated tryptophan metabolite 3‐hydroxyanthranilic acid levels in middle‐aged adults Aim Recent pre-clinical evidence suggests that the tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) and the related enzyme activity along the kynurenine metabolic pathway (KP) are associated ...

Check out our new paper now out in Acta Physiologica on the tryptophan metabolite 3-HAA in the aging and exercise context 👇
@50823zimmer.bsky.social @davidwalzik.bsky.social

onlinelibrary.wiley.com/doi/full/10....

Acute exercise rewires the proteomic landscape of human immune cells https://www.medrxiv.org/content/10.1101/2025.01.30.25321196v1

Acute exercise rewires the proteomic landscape of human immune cells Exercise-driven alterations of the immune system are a key mechanism in the prevention and treatment of various diseases. Here, we performed mass spectrometry-based proteomics analysis on peripheral b...

Happy to share our new preprint, where we investigate the impact of acute exercise on the proteome of immune cell! Comparing high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE), we found numerous proteins that were differentially expressed in PBMCs. (1/12)

The AI revolution is running out of data. What can researchers do? AI developers are rapidly picking the Internet clean to train large language models such as those behind ChatGPT. Here’s how they are trying to get around the problem.

The sad realistion that someone will have to do experiments at some point....damn it

"The AI revolution is running out of data. What can researchers do?"

www.nature.com/articles/d41...

How does exercise exert preventive and therapeutic effects in different diseases? What is the molecular basis of these effects and how are exercise signals mediated on a cellular level? A 🧵on our lates review in Signal Transduction and Targeted Therapy:
(1/13)