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Juan Carlos De la Concepcion

@delaconcepcionjc

Plants, Pathogens and Procrastination Emmy Noether Fellow at ZMBP

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20.10.2023
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Latest posts by Juan Carlos De la Concepcion @delaconcepcionjc

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I am excited to share with you an amazing video on the NLRP3 inflammasome pathway generated by talented Ann Liu from the Janet Iwasa lab @jiwasa.bsky.social @ann-hl.bsky.social. It shows the real structures of the pathway from #NLRP3, #ASC, #caspase-1, #GSDMD, #IL-1b, to #NINJ1. Enjoy!

06.03.2026 19:48 πŸ‘ 10 πŸ” 3 πŸ’¬ 0 πŸ“Œ 1
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Meanwhile AI's greatest contribution to academia will be one of this showing up at the doorstep of every unproductive leech plaguing Universities.

07.03.2026 05:29 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

And an appointment to sign in person with someone whose office open only in days with full moon between 9:15 and 10:45

07.03.2026 05:20 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress Cryo–electron tomography reveals how mitochondria reorganize their translation and folding systems under proteostatic stress.

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress | Science Advances www.science.org/doi/10.1126/...

05.03.2026 15:31 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Kick-off meeting of our GreenRobust cluster of excellence last week. Exciting times ahead for plant sciences by bringing together an extraordinary bunch of enthusiastic scientists and human beings!

04.03.2026 08:12 πŸ‘ 28 πŸ” 13 πŸ’¬ 1 πŸ“Œ 1
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2026 has been a remarkable year for me so far (despite the current world events): opening my lab at the University of Zurich, assembling an amazing group of people in the group, and celebrating it with a fantastic lab warming party. Figured it's also time for a small profile refresh.

03.03.2026 22:46 πŸ‘ 40 πŸ” 10 πŸ’¬ 1 πŸ“Œ 0
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High-frequency biparental inheritance of plant mitochondria upon chilling stress and loss of a genome-degrading nuclease - Nature Plants Maternal inheritance of mitochondria breaks down in the cold when a mitochondrial DNA degrading nuclease is defective, resulting in biparental inheritance that can rescue mitochondrial mutations and g...

Mitochondria can indeed be inherited from the father! πŸ€
In this new study, we uncovered the molecular mechanisms underlying mitochondrial inheritance in Nicotiana tabacum. @natplants.nature.com

doi.org/10.1038/s414...

03.03.2026 17:34 πŸ‘ 27 πŸ” 12 πŸ’¬ 1 πŸ“Œ 0

We are very excited to share a new resource from our team: spatial subcellular proteome maps in plants! We developed an MS-based method that registers localizations of about 8000 proteins in Arabidopsis roots in a single experiment.

(1/9)
www.biorxiv.org/cgi/content/...

03.03.2026 06:53 πŸ‘ 111 πŸ” 68 πŸ’¬ 2 πŸ“Œ 1

High resolution, proteome-wide mapping of subcellular protein localization in plants https://www.biorxiv.org/content/10.64898/2026.02.27.708449v1

02.03.2026 23:04 πŸ‘ 11 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
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As a forest researcher, I very often (far too often) encounter questions such as: What does a forest researcher do in Spain? Do you even have forests there? The international image of Spain as a mostly desert-like country, and mainly associated with sun and beach,has contributed to this stereotype.

02.03.2026 12:29 πŸ‘ 14 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0

There is a week left to apply for two available positions in my lab @ipbhalle.bsky.social

- PhD: ipb-halle.mhm.jobs/12-phd-posit...

- Postdoc: ipb-halle.mhm.jobs/13-postdocto...
Earliest start date: 01/05/2026.

We are interested in plant immune receptor biochemistry and evolution. Please share!

02.03.2026 11:16 πŸ‘ 33 πŸ” 39 πŸ’¬ 0 πŸ“Œ 0

Join us at the #SEBconference Florence 2026 to discuss #Plant Robustness! 🌱πŸ”₯

@kaspervangelderen.bsky.social and I are organising the P12 session "Plant robustness from molecules to ecosystems" with the support of @greenrobust.de

Check the program and submit your abstract by March 6th! πŸ‘‡

02.03.2026 10:50 πŸ‘ 19 πŸ” 16 πŸ’¬ 0 πŸ“Œ 0

"Every gun that is made, every warship launched, every rocket fired signifies...a theft from those who hunger & are not fed, those who are cold & are not clothed. This world in arms...is spending the sweat of its laborers, the genius of its scientists, the hopes of its children."

28.02.2026 23:35 πŸ‘ 29 πŸ” 10 πŸ’¬ 0 πŸ“Œ 0
Addgene: OpenPlant Kit Use the OpenPlant toolkit for genetic engineering of the plant synthetic biology model Marchantia polymorpha.

The OpenPlant kit is finally available from Addgene as... a kit :)
www.addgene.org/kits/haselof...
@addgene.bsky.social #marchantia #synbio

26.02.2026 01:08 πŸ‘ 25 πŸ” 10 πŸ’¬ 0 πŸ“Œ 1
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Really happy to see this one out: www.sciencedirect.com/science/arti... Alibek's drive & great coll w/ friends @gekaragoz.bsky.social & E. Hallacli resulted in a cool story that starts with our beloved #Marchantia and ends with iPSC-derived neurons 🀩πŸ€ͺ A short 🧡

23.02.2026 17:05 πŸ‘ 119 πŸ” 53 πŸ’¬ 6 πŸ“Œ 7

This is the kind of thing a rich CEO says at the beginning of a science fiction movie to establish for the audience that he is a sociopath and the villain.

21.02.2026 19:54 πŸ‘ 7005 πŸ” 1861 πŸ’¬ 156 πŸ“Œ 21
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RNA splicing generates a functionally specialized Rep protein isoform in geminiviruses β€” enabling timely control of the viral cycle. Strikingly, similar strategies might have evolved in DNA viruses infecting different kingdoms: www.biorxiv.org/content/10.6... Spearheaded by @delphinem-p.bsky.social!

20.02.2026 09:31 πŸ‘ 51 πŸ” 34 πŸ’¬ 0 πŸ“Œ 1
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Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA

www.science.org/doi/10.1126/...

co-first with: @andschwarz.bsky.social

with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more

🧡 0/6
#MolBio πŸ§ͺ

19.02.2026 19:09 πŸ‘ 85 πŸ” 34 πŸ’¬ 4 πŸ“Œ 6
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Announcing the publication of TAIR12: Consult the fully reannotated genome on the European Nucleotide Archive - Phoenix Bioinformatics TAIR (The Arabidopsis Information Resource), together with our nonprofit host Phoenix Bioinformatics, is pleased to announce the public release of TAIR12

πŸŽ‰πŸ“£ #TAIR12, the latest reannotation of the Arabidopsis thaliana genome, is now available under accession number PRJEB100887 on ENA and NCBI!

Thank you all the volunteer researchers whose hard work has made this possible!

#plantscience #plantbiology πŸ§ͺ

bit.ly/3ZHtneT

19.02.2026 18:40 πŸ‘ 97 πŸ” 59 πŸ’¬ 3 πŸ“Œ 2
Eva-Sophie Wallner and Marion Clavel standing together on a snowy campus, smiling at the camera. Behind them are a modern office building and a greenhouse, with bright winter sunshine illuminating the scene.

Eva-Sophie Wallner and Marion Clavel standing together on a snowy campus, smiling at the camera. Behind them are a modern office building and a greenhouse, with bright winter sunshine illuminating the scene.

Shoutout to yesterday’s guest @eswallner.bsky.social, who visited us from @gmivienna.bsky.social for her talk β€œLessons from sporeling development: How to form plant organs and meristems de novo?” - fascinating perspective on plant development!🌱
Thanks as well to @thevirusmc.bsky.social for hosting πŸ™

19.02.2026 08:32 πŸ‘ 22 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0
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The mechanical properties of Arabidopsis thaliana roots adapt dynamically during development and to stress Brillouin microscopy reveals in vivo dynamics of mechanical properties during plant development and response to stress.

Our work now on its final version. We mapped the mechanical properties of roots at tissue and single cell levels using Brillouin microscopy and molecular rotors. Additional mutants and stress measurements from what we previously showed in the preprint are included.
www.science.org/doi/10.1126/...

18.02.2026 20:22 πŸ‘ 58 πŸ” 32 πŸ’¬ 5 πŸ“Œ 3
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The actin cytoskeleton is required to maintain plant cell division orientation against cellular geometry Actin guides plant cell division, shaping tissues in ways that defy geometric constraints.

What a treat to see the work from Camila Goldy @camilagoldy.bsky.social et al., @rdplab.bsky.social @ensdelyon.bsky.social now published 🫢

www.science.org/doi/10.1126/...

18.02.2026 19:58 πŸ‘ 45 πŸ” 20 πŸ’¬ 1 πŸ“Œ 1
OryzaNet | Coming soon

OryzaNet is a new BBSRC-funded rice research network launching Spring 2026.

We are inviting researchers, social scientists, stakeholders & innovators to register interest ahead of launch.

www.oryzanet.com

17.02.2026 10:53 πŸ‘ 11 πŸ” 9 πŸ’¬ 0 πŸ“Œ 0

If anyone is interested in working on these bacteria @johninnescentre.bsky.social has protocols, strains, plasmids and a genome database available here: streptomyces.org.uk

16.02.2026 20:01 πŸ‘ 11 πŸ” 13 πŸ’¬ 0 πŸ“Œ 1

Plant-parasitic nematode microRNAs hijack plant AGO1 to induce host-cell reprogramming https://www.biorxiv.org/content/10.64898/2026.02.13.705329v1

16.02.2026 17:01 πŸ‘ 10 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
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Ribosome biogenesis and homeostasis: in the front line to cope with cellular stress Cells must continuously adapt to both internal and environmental stresses by finely tuning their molecular and metabolic activities. One of the most r…

Fascinated by how cells adapt to a plethora of stimuli?

​This review describes how cells use and modulate #ribosomes to cope with stresses. We discuss the central role of ribosome-associated processes in #cellplasticity, #signaling, #geneexpression and #diseases πŸ•Ή

@cbitoulouse.bsky.social

15.02.2026 17:12 πŸ‘ 7 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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I just published: Adeline Harant: Keeping an open mind is key for a fulfilling career in science

A much-deserved tribute to the amazing Adeline Harant and her leadership at the bench and beyond. She also brings a dose of sanity to the @KamounLab madhouse. kamounlab.medium.com/adeline-hara...

21.11.2025 14:17 πŸ‘ 22 πŸ” 12 πŸ’¬ 0 πŸ“Œ 1
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Dihydroxyhexanoic acid biosynthesis controls turgor in pathogenic fungi Many plant pathogenic fungi penetrate host surfaces mechanically, using turgor pressure generated by specialized infection cells called appressoria. These appressoria develop semipermeable cell walls ...

Out in @science.org this week, two fungal enzymes synthesise DHHA, which controls cell wall porosity and turgor in plant pathogenic fungi www.science.org/doi/10.1126/...

#mycology
#plantscience

13.02.2026 09:46 πŸ‘ 50 πŸ” 22 πŸ’¬ 0 πŸ“Œ 0

Check out this cool #cryo-EM study spearheaded by our neighbor @tafurlab.bsky.social and his colleagues! A must-read for anyone interested in the molecular mechanisms governing (m)TORC1 regulation. Congrats to all involved! πŸŽ‰

13.02.2026 16:56 πŸ‘ 6 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate Polyamines are often associated with ribosomes and are thought to stabilize their integrity. In Arabidopsis, the polyamine thermospermine (tSpm) affects xylem cell fate. tSpm induces translation of SU...

In @science.org this week, thermospermine affects ribosome methylation, which in turn regulates translation of xylem development proteins www.science.org/doi/10.1126/...

#plantscience

13.02.2026 09:43 πŸ‘ 30 πŸ” 20 πŸ’¬ 1 πŸ“Œ 1