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Connor McShaffrey

@cmcshaff

CogSci / Bioengineering PhD Candidate, NSF Graduate Research Fellow (he/him) https://sites.google.com/view/connor-mcshaffrey/bio Indiana University, Vassar '21 πŸŽ“ Modeling life and its limits with dynamical systems 🦠 microscopy for fun πŸ”¬

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03.09.2023
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Latest posts by Connor McShaffrey @cmcshaff

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πŸ“£πŸ“£πŸ“£

Applications for the 2026 Diverse Intelligences Summer Institute (DISI) are now open!!

Are you interested in intelligence, mind, and cognition in all its forms? Early-career scholars from any disciplineβ€”and storytellers in any mediumβ€”are encouraged to apply!

More info: disi.org

02.03.2026 18:12 πŸ‘ 26 πŸ” 20 πŸ’¬ 0 πŸ“Œ 5
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New paper out in PRL!
With @artemyte.bsky.social and Sosuke Ito, we combine stochastic thermodynamics with nonequilibrium MaxEnt in large networks to infer entropy dissipation in high-dimensional systems from time series (up to 1000 variables!)

journals.aps.org/prl/abstract...

20.02.2026 17:07 πŸ‘ 8 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

She's earned it! My cat has attitude and the gremlin isn't even two years old yet

20.02.2026 17:23 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I always gave her so many belly rubs because I suspected she had mastery of the dark arts

20.02.2026 17:05 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
A picture of Annalee and Charlie Jane bundled up in their winter clothes, inside a tunnel made of twinkling LED lights. They are smiling and Annalee is sticking out their tongue. A friend is photobombing them in the background, popping up and smiling over Charlie Jane's shoulder.

A picture of Annalee and Charlie Jane bundled up in their winter clothes, inside a tunnel made of twinkling LED lights. They are smiling and Annalee is sticking out their tongue. A friend is photobombing them in the background, popping up and smiling over Charlie Jane's shoulder.

A picture of several novels by Charlie Jane Anders and Annalee Newitz. "Charlie Jane Anders and Annalee Newitz from Tor Books Supporting Miss Major Alexander L Lee TGIJP Black Trans Cultural Center" Book Bundle.

A picture of several novels by Charlie Jane Anders and Annalee Newitz. "Charlie Jane Anders and Annalee Newitz from Tor Books Supporting Miss Major Alexander L Lee TGIJP Black Trans Cultural Center" Book Bundle.

This deal is incredible & it's for the best cause! You can get ALL the fiction by me and @charliejane.bsky.social from @humblebundle.com for a low, low price -- and all sales benefit the Miss Major Alexander L. Lee Black Trans Justice Center. www.humblebundle.com/books/charli...

03.02.2026 19:26 πŸ‘ 95 πŸ” 58 πŸ’¬ 5 πŸ“Œ 6
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Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis, with T cell responses against ANO2 occurring in over half of patients. These ANO2-specific T cells shar...

Epstein-Barr Virus #EBV was linked to #MultipleSclerosis - now a plausible cause has been found, misidentification by longterm memory T-cells that pick on the wrong protein, ANO2, instead of the EBV-antigen. Massive inflection towards the elimination of MS!!!
πŸ§ͺ🧠Cell www.cell.com/cell/fulltex...

15.01.2026 01:41 πŸ‘ 872 πŸ” 283 πŸ’¬ 11 πŸ“Œ 47
Saturday Jan 10, 11 am PST
Virtual panel discussion: speculative stories about political protest, resistance, and hope. 
Karen Lord, Annalee Newitz, and Malka Older.
Free! Registration required (see link in post)

Saturday Jan 10, 11 am PST Virtual panel discussion: speculative stories about political protest, resistance, and hope. Karen Lord, Annalee Newitz, and Malka Older. Free! Registration required (see link in post)

Need an antidote to the horror and paralysis? See you tomorrow at 11 pacific time. citylights.com/events/panel...

10.01.2026 01:26 πŸ‘ 74 πŸ” 17 πŸ’¬ 4 πŸ“Œ 0
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The last piece of microscope art I did in 2025 :) reflected light off a surface of a bubble and magnified by 100x, manipulated to give a planet-like effect

Wishing all a great start to 2026!

01.01.2026 19:42 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

It looks like if the mermaid's purse egg-capsule developed into a little person instead of hatching into a skate!

19.11.2025 21:24 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

I was midway through sipping on my drink and almost choked when I read this. Absolute gold.

19.11.2025 21:20 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
A schematic of a death event in a multicellular system, where the loss of one cell results in a collapse in the dimensionality of the system. Each cell's essential variables have their ranges capped by viability constraints.

A schematic of a death event in a multicellular system, where the loss of one cell results in a collapse in the dimensionality of the system. Each cell's essential variables have their ranges capped by viability constraints.

Where does the life-death boundary come from, and how will a cell's dynamics unfold relative to it? Myself, Eran Agmon, and Randy Beer argue for a theory of cellular viability, with new global organizing principles for cell fate.

Preprint: arxiv.org/pdf/2511.07847

12.11.2025 18:36 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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How β€œintelligent” is a slime mold? When it solves mazes, it might not be thinking:it’s obeying physics. Our new paper with
@jordiplam.bsky.social shows how it follows a least action principle,letting physics do the job arxiv.org/pdf/2511.08531
@drmichaellevin.bsky.social @docteur-drey.bsky.social

12.11.2025 04:17 πŸ‘ 100 πŸ” 29 πŸ’¬ 11 πŸ“Œ 5

This is some really interesting work at the intersection of animal behavior, agent-environment modeling, and dynamical systems analysis.

Definitely worth checking out!

(Also, Eden is a pretty groovy guy; you should consider following him.)

03.11.2025 19:46 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I've had an increasing number of people ask me why I do not have LLMs automate my paper writing/research for me. My first answer is always on principle. My second is that nothing I work on is so derivative of other work that it is that well-represented in the training set.

27.10.2025 18:31 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

All I know is that it is uncorrupted by the blind use of LLMs. Ah, the joys of being illiterate.

26.10.2025 22:12 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Do you review papers? Check out Earl's @earlkmiller.bsky.social recommendations.
The one that i would emphasize the most:

jocnf.pubpub.org/pub/qag76ip8...

07.10.2025 16:33 πŸ‘ 29 πŸ” 2 πŸ’¬ 2 πŸ“Œ 4
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#ALIFE2025 #TONAL2025 satellite

06.10.2025 00:45 πŸ‘ 12 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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ECSU - ALIFE

It was an honor to be invited to speak at the TONAL workshop on the role of noise in Artificial Life! www.oist.jp/research/res...

Looking forward to speaking about our recent work again later on at #ALife2025! Paper to be posted soon πŸ™‚

06.10.2025 19:46 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Huntington's disease successfully treated for first time One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

Anyway, here is some actually incredible news

www.bbc.co.uk/news/article...

24.09.2025 11:36 πŸ‘ 554 πŸ” 202 πŸ’¬ 8 πŸ“Œ 24
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Physics of Life: Exploring Information as a Distinctive Feature of Living Systems Living systems are defined by their active acquisition and use of information. This Roadmap surveys current research on life's information processes and their importance for the search for life beyond...

I am super excited to read this paper! Viability, semantic information, and more :)

journals.aps.org/prxlife/abst...

05.09.2025 01:45 πŸ‘ 6 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Hello friends of bluesky! I am finishing my PhD this academic year, and am looking for postdocs and faculty applications in the realm of nonlinear dynamics, biology, complex systems, and CogSci. Any recommendations for places I should be looking at?

29.08.2025 15:51 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Congrats Will!

29.08.2025 14:01 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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🀫

27.08.2025 01:38 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

You're tempting me lol

26.08.2025 20:52 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Going to change my dissertation proposal to this three days before the defense...

26.08.2025 19:14 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Anyone interested in autopoiesis and Randall Beer's formalization of it in Conway's Game of Life would probably enjoy looking at Tom's undergrad thesis, where he extends the ideas to the "Larger than Life" and "Real Life" family of cellular automata!

17.08.2025 16:40 πŸ‘ 8 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

It was a pleasure, Tom :) very excited to see what comes next. Hope you are getting settled in your new home!

17.08.2025 16:37 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

This looks like a nice entry point for folks interested in the intersection of dynamical systems theory and cell biology!

04.08.2025 18:37 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0