M-Clotilde ALVES GUERRA

Cancer cells get power boost by stealing mitochondria from nerves Nature - The theft probably helps the cells to spread around the body, and preventing it could provide a path to treatment, researchers say.

Cancer cells turbocharge themselves by stealing the energy-producing units from neurons in tumours

https://go.nature.com/4nnVyda

1️⃣ Inscrivez un proche (+50 ans) 👉 urlz.fr/tZkp
2️⃣ Mr. Popo le relance avec humour jusqu’au test.
3️⃣ Un simple "J’ai fait mon test" stoppe tout.
✅ Simple, gratuit, à faire chez soi !

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#JournéeMondialeContreLeCancer #NeLachezRien #DepistageColorectal #MrPopo #Prevention

@institutcochin.bsky.social

If you are interested in macrophages, come work in our lab!

Institut Cochin

The 4th of February is commemorated as World Cancer Day.
Cancer research is a strong focus of the Institut Cochin, with 15 teams involved in the studying molecular and cellular mechanisms that favor the development of cancers. A major aim of our research is to develop novel therapies.

We are looking for PhD students and/or postdocs that want to join us to study the metabolism of metastasizing cancer cells with cutting-edge spatial and single cell technologies.
fendtlab.sites.vib.be/en

This is figure 2, which shows the systematic evaluation of the effectiveness and risks of incident use of GLP-1RAs compared to incident use of sulfonylureas, DPP4 inhibitors SGLT2 inhibitors and a control group composed of equal proportions of sulfonylureas, DPP4 inhibitors and SGLT2 inhibitors.

The use of glucagon-like peptide 1 receptor agonists (GLP-1RAs) may be associated with a broad spectrum of health effects, including decreased risk for 42 health outcomes and increased risk of 19 health outcomes, according to a study in Nature Medicine. https://go.nature.com/3ClpHHx #Medsky 🧪

This is HUGE !!!

Mapping the metabolomic impact of pharmacological agents enables dissecting their mechanism of action in an unbiased manner.

Congrats to @zampierilab.bsky.social and all involved for opening such major avenues for the deciphering of drug polypharmacology 🤩

iPSC models of mitochondrial diseases Mitochondrial diseases are historically difficult to study. They cause multi-systemic defects with prevalent impairment of hard-to-access tissues such…

Delighted to share our latest review article summarizing the use of induced pluripotent stem cells (iPSCs) to model mitochondrial disorders with 2D and 3D organoid approaches.

www.sciencedirect.com/science/arti...

Lactate homeostasis is maintained through regulation of glycolysis and lipolysis Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These invol...

Lactate homeostasis is maintained through regulation of glycolysis and lipolysis: Cell Metabolism www.cell.com/cell-metabol...

As the new Editor-in-Chief I encourage you to submit your work to Oncogenesis (IF 5,9) www.nature.com/oncsis/
High impact, peer-reviewed open access journal publishing articles exploring mechanistic insight and molecular basis of cancer and related phenomena.

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

Immune evasion through mitochondrial transfer in the tumour microenvironmenthttps://

www.nature.com/articles/s41586-024-08439-0

CD45-PET is a robust, non-invasive tool for imaging inflammation - Nature A non-invasive in vivo positron emission tomography imaging approach detects inflammatory disease using various preclinical models.

CD45-PET is a robust, non-invasive tool for imaging inflammation

www.nature.com/articles/s41...

Unique opportunity to join the @suracelab.bsky.social to work in immunometabolism in cancer.

Laura is a great scientist and mentor! Don't miss this opportunity!

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

Organelle transfer is an area of biology that never ceases to amaze. A lot of creative mechanisms that cancer cells could teach us for avoiding immunogenicity.

www.nature.com/articles/s41...

Great review from @alteamanzanolab.bsky.social and #AyeletErez!

More than 40% of postdocs leave academia, study reveals Publishing highly cited papers helps postdoctoral researchers to land a faculty job.

More than 40% of postdoctoral researchers leave academia, according to a study of some 45,500 researchers’ careers

https://go.nature.com/3EdzX56

Cancer cells ‘poison’ the immune system with tainted mitochondria Immune cells lose their cancer-fighting prowess after taking tumours’ organelles on board.

Cancer cells can poison attacking immune cells by filling them with defective mitochondria ― dampening the body’s defensive forces and helping the tumour to evade eradication

https://go.nature.com/42qye6G

We are looking for a #Postdoc to join our team to work on a funded project by La Ligue investigating the role of #gut permeability as a cause of #cancer with #age. 🐟🐟🐟
#zebrafish #telomerase #microbiome DEADLINE: 29/Jan/2025
Please help us spread the word! 🙏

New studies from our lab by Tevis Vitale and Jason Liang in @naturecancer.bsky.social Selective deficiency of complex I subunits causes tumor immunogenicity via T cell surveillance and Immune Checkpoint Blockade responsiveness Collaboration with Widlund, Gygi and Wucherpfennig labs rdcu.be/d6BgJ

Diet-wide analyses for risk of colorectal cancer: prospective study of 12,251 incident cases among 542,778 women in the UK - Nature Communications Colorectal cancer has been linked to multiple environmental factors, however, the role of diet remains incompletely understood. Here, the authors complete a diet-wide association study and identify a potentially protective role of dairy intake in colorectal cancer incidence, driven largely by calcium.

A diet-wide association study in Nature Communications identifies a potentially protective role of dairy intake in colorectal cancer incidence, driven largely by calcium. 🧪

Don't hesitate to apply and join our dynamic research environment 😊! please spread the word !

Inter-organ communication is a critical machinery to regulate metabolism and aging Inter-organ communication (IOC) is a complex mechanism involved in maintaining metabolic homeostasis and healthy aging. Dysregulation of distinct forms of IOC is linked to metabolic derangements and age-related pathologies, implicating these processes as a potential target for therapeutic intervention to promote healthy aging. In this review, we delve into IOC mediated by hormonal signaling, circulating factors, organelle signaling, and neuronal networks and examine their roles in regulating metabolism and aging. Given the role of the hypothalamus as a high-order control center for aging and longevity, we particularly emphasize the importance of its communication with peripheral organs and pave the way for a better understanding of this critical machinery in metabolism and aging.

www.cell.com/trends/endoc...

@cp-trendsendomet.bsky.social

🚨🚨🚨
Call is now open!!! Deadline approaching...
Wanna become our new beloved colleague and be part of a stimulating (and friendly) scientific community ??? We are perfectly located in beautiful Paris with exciting work environment and state-of-the-art core facilities
APPLY 👇👇👇👇👇

#Communiqué 🗞️ La MASH est une maladie hépatique chronique grave qui touche 4 à 6 % de la population adulte. Une nouvelle étude révèle qu’elle peut être d’origine génétique ou liée à des désordres métaboliques.

👉 www.cnrs.fr/fr/presse/st...

Le CNRS a appris avec une grande tristesse le décès d’Alain Fuchs, Président du CNRS de 2010 à 2017. Il a été une personnalité engagée au service de l’enseignement supérieur et de la recherche en France. Le CNRS présente ses condoléances à sa famille et ses proches.
👉 www.cnrs.fr/fr/presse/de...

New in Science Magazine this week: two research articles and a Perspective describing synthetic biology gene circuitry for bespoke cellular function - in this case applied to T cells!

Research:
buff.ly/41pkAAb
buff.ly/41gMxu0

Perspective
buff.ly/3ZFUUy8

@science.org

@institutcochin.bsky.social is opening a position for a scientist wishing to establish his/her independent team. Application deadline 21/01/2025. For details and application:
institutcochin.fr/en/node/24264