Paolo E Porporato

Let's Start this 2025 (and this new Social) with a Post :)

Our review on inter-organ crosstalk driving Cancer Cachexia is now available @cp-trendsendomet.bsky.social

Systemic metabolic crosstalk as a driver of cancer cachexia by Wyart et al.

#Research #CancerCachexia #Metabolism #Muscle

Aspartate signalling drives lung metastasis via alternative translation - Nature Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.

#WeekendRead! #MetabolismPower! @fendtlab.bsky.social &co show @ Nature that pulmonary aspartate favors lung metastases via CREB & DOHH dependent hypusination of the alternative translation factor eIF5A, driving TGFb & collagen deposition! www.nature.com/articles/s41...