Check out the full study here: doi.org/10.64898/202...
Kudos to the fantastic team, especially lead author Sowmya Narayan and our incredible collaborators.
By combining advanced behavioral phenotyping with whole-brain c-Fos mapping, manganese-enhanced MRI, and transcriptomics in mouse models, we found that developmental stress often has opposite neurobiological effects in males vs. females.
Iโm thrilled to share our latest preprint from the lab, now available on BioRxiv! We investigated how early life adversity (ELA) shapes the adult brain, and the results are a stark reminder that sex isn't just a variable but leads to fundamentally different stress-induced mechanistic consequences
This is the path to robust, translational data. ๐๐จ๐ง'๐ญ ๐๐๐ง๐ข๐! Read the full guide and join the shift to deep phenotyping.
Thanks to all co-authors and the incredible teamwork including @benjurek.bsky.social, Patrick Schlegel, @london-k-aman.bsky.social, Bartosz Zglinicki and @mikeyslezak.bsky.social
We provide:
- A standardized workflow for long-term home-cage monitoring in mice.
- A practical guidance on experimental setups for 24-hour recordings.
- A comparison of contrast- vs. ML-based tracking tools, with pros, cons, and use-cases
.. and much more!
Check out our new paper in Neuroscience & Biobehavioral Reviews: "๐ณ๐๐๐-๐๐๐๐ ๐
๐๐๐ ๐๐๐๐๐๐๐๐๐๐๐ ๐๐ ๐๐๐๐๐๐๐๐๐๐ ๐๐๐๐๐๐ ๐๐ ๐๐๐๐ ๐๐๐๐๐ ๐๐๐๐๐๐๐๐ ๐๐๐๐๐๐๐๐๐๐"
This paper is your essential ๐๐ข๐ญ๐๐ก๐ก๐ข๐ค๐๐ซ'๐ฌ ๐๐ฎ๐ข๐๐ to achieving unprecedented insight into complex rodent behavior. www.sciencedirect.com/science/arti...
To truly understand the neurobiological basis of complex behaviors - the real ๐ฆ๐๐๐ง๐ข๐ง๐ ๐จ๐ ๐ฅ๐ข๐๐, ๐ญ๐ก๐ ๐ฎ๐ง๐ข๐ฏ๐๐ซ๐ฌ๐, ๐๐ง๐ ๐๐ฏ๐๐ซ๐ฒ๐ญ๐ก๐ข๐ง๐ - we must overcome the limitations of traditional, short-term behavioral tests.
Interesting talk by @kgoepfrich.bsky.social on RNA design and synthetic cells.
๐จOpen position at #FENS!
๐ญDo you want to help strengthen the voice of #neuroscience?
Apply for the Advocacy and Engagement Internship at FENS!
๐๏ธ The deadline for applications is 31 October!
๐ https://loom.ly/2Qy18y8
Looking forward to this exciting conference. If you are interested in the latest science on the developmental origins of mental illness, join me and my co-chair @talliezee.bsky.social for our session on Sunday morning at 11:20am.
Very happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens.
Big kudos to first co-authors David Mallet & Doฤukan รlgen, our amazing team, and collaborators!
๐ Paper: doi.org/10.1016/j.bi...
Latest lab preprint! Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear... so we dived in:
www.biorxiv.org/content/10.1...
Important initiative ๐
Ready for some really hot ๐ฅ๐ฅต data on stress and trauma effects across the life span, join us at the 17:30 symposium @ebbsociety.bsky.social with @biancasilvalab.bsky.social.
The heat wonโt stop the energy โ science (and fans!) in full swing!
๐๐ชญ๐ช
#EBBS2025
In Bordeaux for the #EBBS meeting. Looking forward to 4 exciting days of science
๐จ NEW PAPER ๐จ
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...
The Be Open about Animal Research Day is starting now!
Show your support and share on #BOARD25
๐It's happening - The Neurobiology of Grief International Network (NOGIN) comes to Europe! We are happy to host NOGIN from Sept 17-19 in Regensburg/DE. Registration is already open, seats are strictly limited to 100 participants. More information here:
www.neurobiologyofgrief.org/events
Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...
Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry www.sciencedirect.com/science/arti...
Read about our recent discoveries on mechanisms that can drive resilience in females.
www.psych.mpg.de/2949097/news...
So well deserved! Congratulations ๐๐ป๐๐ป๐๐ป
The Peter Seeburg Integrative Neuroscience Prize honors groundbreaking work that bridges molecular & systems neuroscience to advance our understanding of cognition, emotion, memory, & decision-making. ๐ฌ Celebrate bold science. Nominate now.
#Neuroscience #BrainResearch
www.sfn.org/careers/awar...
Intergenerational Effects of Stress - A Focus on Learning and Memory
doi.org/10.1007/7854...
We're using a lab TikTok account to try and get the message out about why science is important. The latest post from @neurani.bsky.social and @g-lia-lcells.bsky.social with footage from Hunter Sowards lab visit www.tiktok.com/t/ZP82fpRCA/
Thanks to all the co-authors and collaborators! I also want to point out the important contribution of our transgenic (not transgender) mice to this study.
Our data especially highlight the importance of studying sex differences in how individuals cope with stress.
New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...
Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis
www.nature.com/articles/s41...
