Roberto Meneses-Valdés

🚀New preprint w/ @roberto_amv: We used chemogenetics to precisely control mitochondrial H2O2 in skeletal muscle in vivo. This exposes a dose-dependent sequence: translation suppression → proteolysis → denervation-like → degeneration @tejensen23 www.biorxiv.org/content/10.1...

Chemogenetic Mitochondrial H2O2 Generation Triggers Dose-Dependent Skeletal Muscle Wasting Signatures Mitochondrial hydrogen peroxide (mtH2O2) has long been implicated in skeletal muscle atrophy, yet its direct role in vivo has remained unresolved due to methodological constraints. Here, we aimed to e...

Thrilled to share our new study (as a preprint) from the @tejensen23 lab showing, for the first time, that mitochondrial H₂O₂ is sufficient to trigger muscle wasting signatures and suppress protein synthesis. Huge thanks to @MuscleBiology and everyone involved!
www.biorxiv.org/content/10.1...

Chemogenetic Mitochondrial H2O2 Generation Triggers Dose-Dependent Skeletal Muscle Wasting Signatures https://www.biorxiv.org/content/10.1101/2025.08.19.671046v1

mTOR Ser1261 is an AMPK‐dependent phosphosite in mouse and human skeletal muscle not required for mTORC2 activity mTOR Ser1261 is an AMPK-dependent phosphosite in human and mouse skeletal muscle that responds to exercise but not insulin, plays an unclear role in mTORC1 regulation, and is not required for mTORC2 ....

Our new FASEBJ paper. We looked into mTOR Ser1261 phosphorylation in human and mouse muscle, proposed by Diane Fingar's lab to be first an Akt and then AMPK site regulating mTORC1 and 2 activity. Clearly AMPK site but impact on mTORC unclear in our hands faseb.onlinelibrary.wiley.com/doi/10.1096/...

Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison Striated muscle cells, encompassing cardiac myocytes and skeletal muscle fibers, are fundamental to athletic performance, facilitating blood circulati…

Happy to share our latest publication with the Thomas Jensen team, featured in Free Radical Biology and Medicine last October
www.sciencedirect.com/science/arti...