Hannelore Longin

Protein domains have no single definition, so why stick to one segmentation? 🧩

Instead of forcing structures into rigid classifications, we built AFragmenter. It uses AlphaFold PAE networks for a tuneable approach to domain parsing.

You control the granularity. 👇
🔗 doi.org/10.1093/bioi...

Protein Structure Informed Bacteriophage Genome Annotation with Phold Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for use as therapeutic agents. Here we introduce Phold, an annotation framework utilis...

Stoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation #phagesky 1/n

www.biorxiv.org/content/10.1...

Synteny-aware functional annotation of bacteriophage genomes with Phynteny Accurate genome annotation is fundamental to decoding viral diversity and understanding bacteriophage biology; yet, the majority of bacteriophage genes remain functionally uncharacterised. Bacteriopha...

🚨 New preprint 🚨

My phage annotation tool, Phynteny, finally has a preprint and a brand new version powered by a cool AI transformer architecture and protein language models! #phagesky

www.biorxiv.org/content/10.1...

Curious about our findings and where we're headed? Happen to be at #ISMB2025 ? Come check out
my poster (A-229, function COSI) today!

Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins Phages, the viruses of bacteria, harbor an incredibly diverse repertoire of proteins capable of manipulating their bacterial hosts, inspiring many medical and biotechnological applications. However, t...

📣 New preprint alert!

Happy to share the first results from our effort to reannotate Pseudomonas #phage proteins of unknown function, using structural bioinformatics.

📄 doi.org/10.1101/2025...

We've folded a lot of proteins! You can see some of them here @linsalrob.bsky.social @gbouras13.bsky.social

Hip hip hooray: our #PTM conservation tool FLAMS turns 1 🎂

To celebrate, we have added handy new features to FLAMS web, incl. 3D visualization of hit proteins & PTM sites with known active/binding sites.

Come check it out @ tinyurl.com/flamsweb & let us know what you think!

1/11 - With Karin Mitosch and Clément Potel + colleagues in Savitski lab and @typaslab.bsky.social @embl.org, I’m very happy to share our discovery of a hyper-promiscuous phage protein kinase (T7K) which broadly deactivates bacterial defenses! 🦠
www.biorxiv.org/content/10.1...