Russell Rogers, Ph.D.

For the 12th year in a row, @smidtheart.bsky.social has been ranked #1 in California for Cardiology, Heart, and Vascular Surgery by @usnews.com!
www.cedars-sinai.org/newsroom/ced...

Pleased to share our paper: #EVs released from #heart #postMI travel to #brain and cause #neuroinflammation, underlying #depression. Work of Ke Liao, PhD

ahajournals.org/doi/epub/10.11…

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging NAD depletion in skeletal muscle does not impair tissue integrity and function or accelerate aging, as shown in a mouse model with an 85% decrease in muscle NAD+ levels. Muscle structure, metabolism, and mitochondrial function remain unaffected, suggesting that NAD depletion does not drive age-related muscle decline.

Online now: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging

Wonderful Research In Progress update by NIH T32 Fellow, Jonah Zarrow, on developing novel #ncRNA drugs for #Duchenne muscular dystrophy. Important work for #DMD!

@eduardomarban.bsky.social
@smidtheart.bsky.social
@mda.org

Oestrogen Receptor Alpha in Myocyte Maintains Muscle Regeneration in Duchenne Muscular Dystrophy Background Oestrogen receptor alpha (ERα) plays an important role in maintaining mitochondrial function and regulating metabolism in skeletal muscle. However, its alterations and potential mechanism...

Oestrogen Receptor Alpha in Myocyte Maintains Muscle Regeneration in Duchenne Muscular Dystrophy
onlinelibrary.wiley.com/doi/full/10....

Mechanisms and regulation of DNA end resection in the maintenance of genome stability - Nature Reviews Molecular Cell Biology DNA end resection is crucial for most DNA double-strand break repair pathways. This Review discusses the molecular mechanisms of end resection and its regulation, focusing on the roles of post-transla...

ICYMI - New #Review on #DNARepair

In this Review, Raphael Ceccaldi and @cejkalab.bsky.social discuss the mechanisms and regulation of DNA-end resection, which is crucial for the repair of DNA double-strand breaks by most repair pathways.

🔗 go.nature.com/4iSKphQ

Preclinical Study: After Heart Attack, a Boost in Anti-Inflammatory Cells Promoted Healing A scientific technique that rapidly increases the body’s production of anti-inflammatory cells promoted healing from heart attacks in mice, according to a new study by investigators from the Smidt Hea...

Recent paper published in @jclinical-invest.bsky.social from @eduardomarban.bsky.social & Ke Liao finds a #ncRNA that enhances #Treg cells that could potentially repair heart muscle damage after a #HeartAttack & be applied to a variety of inflammatory disorders.
www.cedars-sinai.org/newsroom/pre...

Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers - Skeletal Musc... Background Exercising with low muscle glycogen content can improve training adaptation, but the mechanisms underlying the muscular adaptation are still largely unknown. In this study, we measured subs...

New #SkeletalMuscle paper: Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers. #Myoblue tinyurl.com/4brsea2d

Check out the in-press preview of our @jclinicalinvest paper on regulatory #Tcells — we discovered a #ncRNA that can enhance #Treg dynamics fast enough to improve #MI healing in vivo. New hope for refractory inflammatory and immune conditions?
🔗 www.jci.org/articles/vie...

Much appreciated, Ahmed!

@russellrogers.bsky.social discussed experiments w/Lefer Lab taking advantage of the mechanistic differences between #GLP1RA & #ncRNA #TY1 as therapeutics for #HFpEF. Compelling evidence for synergistic benefits in two rodent models! Potential for less skeletal muscle loss?
@smidtheart.bsky.social

Long-term preservation of muscle function and structure by repeated administration of cardiosphere-derived cells in mdx mice Duchenne muscular dystrophy (DMD) is a progressive disease associated with functional decline. Chronic administration of cardiosphere-derived cell therapy prevents disease-related functional decline f...

Pleased to share out latest work on cell therapy for #Duchenne. We show #deramiocel therapy initiated early protects against disease-related decline in muscle function.

@eduardomarban.bsky.social @smidtheart.bsky.social @stemcellreports.bsky.social @mda.org

Thanks, Matt! I’m delighted this work is now available online.

Great opening lecture by #HFpEF pioneer @dakheartguy.bsky.social on #sarcomere abnormalities— huge differences in #calcium activated force in #myocytes from obese vs morbidly obese patients. Clinical correlation less evident…
@smidtheart.bsky.social #CardioSky

Thank you, Ahmed!

Had a great time at the 75th anniversary meeting of the Muscular Dystrophy Association discussing our work on #ncRNA in #Duchenne MD. Honored to be a recognized as a grant recipient of MDA to study cell-free therapies for #DMD.

@mda.org @eduardomarban.bsky.social @smidtheart.bsky.social

Nuclear and genome dynamics underlying DNA double-strand break repair Nature Reviews Molecular Cell Biology, Published online: 17 March 2025; doi:10.1038/s41580-025-00828-1Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the…

New Online! Nuclear and genome dynamics underlying DNA double-strand break repair

Genetic tools for investigating the life cycle of extracellular vesicles Nature Reviews Bioengineering, Published online: 17 March 2025; doi:10.1038/s44222-025-00286-6A thorough understanding of the life cycle of extracellular vesicles is essential to unleash their full potential in biomarker identification and therapeutics…

Genetic tools for investigating the life cycle of extracellular vesicles

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

Studying metabolism? Pay attention to time of day Nice collaborative review led by Satchin Panda www.nature.com/articles/s42...

MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers - Nature Communications The nuclear periphery is linked with transcriptional repression, but MyoD1 remains active during myoblast proliferation despite being in this compartment. Here, the authors show that WFS1 tethers MyoD...

New @NatureComms paper: MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers. #Myoblue tinyurl.com/xmdsv5ez

Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy Genome-wide survey of human and mouse DMD tissues suggests EZH2’s role in satellite cells; its inhibition improves prognosis.

New @ScienceAdvances paper: Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy. #DMD #Myoblue tinyurl.com/3jbcw9fp

Lactic acidosis: implications for human exercise performance - European Journal of Applied Physiology During high-intensity exercise a lactic-acidosis occurs with raised myoplasmic and plasma concentrations of lactate− and protons ([lactate−], [H+] or pH). We critically evaluate whether this causes/co...

Lactic acidosis: implications for human exercise performance
link.springer.com/article/10.1...

A satellite cell‐dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity Muscle stem cells (satellite cells) promote adult skeletal muscle adaptation. The presence of satellite cells affects the skeletal muscle methylome response to lifelong wheel running - specifically i...

A short story: “A satellite cell-dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity” @faseborg.bsky.social #myoblue

In 2024, Cedars Sinai performed 682 solid organ transplants, including 137 #HeartTransplants.

It is the remarkable generosity of organ donors & their families that allowed our transplant teams to give 682 patients the chance to have longer and healthier lives.
🔗 cedars-sinai.org/newsroom/ced...

Inspiring kickoff to @fda.gov Cell Therapy workshop with keynote lecture by Sally Temple— PSC-derived neural cells are coming into their own! FDA CBER has been highly supportive of this transformative field.

In an effort to pretend life is normal and we can just talk science, our #journalclub today featured Liz on the lasting epigenomic traces of #obesity; Diana on ML-directed #protein #evolution; and James critiqued #iPSC #cardiomyocyte sheets. A welcome distraction from the prevailing woes about NIH.

Cell Therapies and Tissue-Based Products: A Public Workshop on Generat CBER, OTP is hosting a virtual scientific public workshop on February 25, 2025, titled “Cell Therapies and Tissue-based Products: A Public Workshop on Generating Scientific Evidence to Facilitate Deve...

On Feb 25, @fda.gov is proceeding with its scheduled workshop on #celltherapy. The agenda starts with an address by CBER Director Peter Marks, WarpSpeed hero, and is packed thereafter. Tune in for my session at 230PM EST.
🔗 www.fda.gov/news-events/...

@mkittlesonmd.bsky.social @dakheartguy.bsky.social @russellrogers.bsky.social @eduardomarban.bsky.social @janetweimd.bsky.social @jgoldhaber.bsky.social @keyurshahmd.bsky.social

Our labs got our red on!
@russellrogers.bsky.social @ahmedgibrahim.bsky.social @eduardomarban.bsky.social
#WearRedDay #GoRedForWomen

Stimulating #labmeeting today by #postdoc Salwa Soussi, PhD on #aging and how it is modulated by novel #RNAdrug #TY1. Strong evidence for central role of #cGAS #STING in cardiac #senescence. Animated discussion followed!