To kickstart this new Bluesky account: We're hiring!
The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab.
Details in the flyer — get in touch! 👇
Please keep in mind: 2 cups per day ☕️☕️
Preprint alert!!📑
We're happy to share a new preprint from our associated member, Dr Maximilian Reuter (@reuterlm.bsky.social), on
"Mechanisms of MCM2-7 helicase activation and initial DNA melting at near base-pair resolution"
🔎Read more here: www.biorxiv.org/content/10.6...
Do you work in DNA replication, genome maintenance, chromosome organisation, chromatin maintenance, or a related field? 🧬
Join us for #EESReplication – submissions are welcome from researchers at all career stages!
20 – 23 October 2026
Send your abstract by 28 July: s.embl.org/ees26-13-bl
Thanks to everyone involved! @mrc-lms.bsky.social @imbmainz.bsky.social @sfb1361.bsky.social @speck-lab.bsky.social @tumunich.bsky.social @kliebl.bsky.social
Finally, we map initial DNA unwinding genome-wide at near base-pair resolution. We found that strand separation initiates at the interface between opposing MCM2-7 hexamers, capturing this transient step of helicase activation in vivo for the first time.
By systematically probing all MCM2-7 interfaces in vivo, we identify the Mcm2/5 interface as a unique ssDNA exit gate during helicase activation. This gate extrudes ssDNA as the inactive double hexamer converts into two active CMG helicases while not interfering with ongoing DNA synthesis.
Using a rapamycin-inducible linkage system in living yeast, we show that blocking rotation and separation of the two MCM2-7 hexamers specifically delays release of the Sld3 loading factor, revealing a direct link between helicase mechanics and activation-complex disassembly.
New preprint🎉
Happy to share our collaborative manuscript, where we provide in vivo and genome-wide evidence linking MCM2-7 helicase activation, DNA extrusion to initial origin melting, thereby adding a new mechanistic layer to how eukaryotic DNA replication is initiated.
👉 doi.org/10.64898/202...
📢 One more week to go... exciting fully funded #PhD position for UK candidates to work across #ICR and #Imperial on novel mechanisms in genome stability and #CancerResearch.
#PhDStudentship #LifeSciences #DNAReplication #CRISPR
Our speaker - Prof. Helle Ulrich - invites fresh perspectives on DNA repair & genome stability. 🧬
Continue the conversation at our conference "The Evil Within: Regulation and Repair of Endogenous DNA Damage." (IMB Mainz, 10–13 Mar 2026).
Register → www.sfb1361.de/dnarepairconf2026
We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance.
tiny.cc/vilw001
#PhD #CancerResearch #GenomeStability #Chromatin
We have an open call for a group leader at the Rudolf Virchow Center for Integrative and Translational Bioimaging in Würzburg, Germany.
Generous starting package, vibrant and highly interdisciplinary biomedical research environment.
www.nature.com/naturecareer...
Please spread the word.
💡 PhD student position at the University of Birmingham, UK. Fully funded by MRC AIM doctoral training programme. 4 years. Open to 🇬🇧 🇪🇺 & 🌎. DNA replication 🧬 . Collaboration with Prof Andrew Wilson (Chemistry). Deadline midday (GMT) 9 January 2026. Please share 😀👍
www.findaphd.com/phds/project...
Congrats!!
🚨Post open in our lab! Come work on some cool themes involving metabolism, chromatin, early development 🤓. Pls RT
We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you.
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
My lab at the University of Birmingham have a fully funded 4 year PhD position available, focusing on the molecular mechanisms of the Alternative Lengthening of Telomeres (ALT).
Informal enquiries to r.a.broderick@bham.ac.uk
APPLICATION LINK:
sits.bham.ac.uk/urd/sits.urd...
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
@mpercharde.bsky.social & I after presenting our experience of setting up the @mrc-lms.bsky.social Roving Researcher scheme to support Postdocs on leave, in the Research Culture session at #MRCBiomedicine2025
Look at that view! Blooming love London
📣 Looking for a 3-Year Postdoc @johninnescentre.bsky.social to join my Wellcome project.
This is a highly interdisciplinary project that explores chromatin dynamics in 🌱 plant responses across timescales, from circadian rhythms to seasonal changes
📅 Closes on 10 Dec.
www.jic.ac.uk/vacancies/36...
Registration is open!🧬
Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers.
📅 Deadline for early registration: Jan 10, 2026
🔗 dnarepairmeeting-egmond2026.com
🧬 List of 2026 DNA repair and genome stability conferences, now updated. Please let me know if there is anything missing!
docs.google.com/spreadsheets...
Archaeal cells whose DNA has been stained with a blue dye. Zoomed-in images of mutant cells that display chromosome segregation defects.
High-resolution images of DNA-protein complexes obtained with atomic force microscopy. Upon binding, the protein bridges distant sites, forming loops.
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
Congratulations Erin! Exciting times 😊
Blue-sky, I need your help. Is alphafold good in predicting protein-protein interactions involving beta sheets?
Registration is open!
Join us at IMB Mainz from 10–13 March 2026 for the 2nd International IMB & SFB 1361 Conference on "The Evil Within: Regulation and Repair of Endogenous DNA Damage".
Don't miss this conference and register now via www.sfb1361.de/dnarepairconf2026
#ISC26DNArepair #IMBMainz
We are launching 11 new #PhD opportunities today!
If you would like to contribute to the research at the LMS apply today!
#medicalscience #lifescience
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
We are deeply saddened to announce the unexpected passing of our colleague Dr Nard Kubben. He joined IMB as a Group Leader in 2021, bringing a passion for understanding ageing & improving human health. Our heartfelt condolences go to his family, friends & all who knew him.
www.imb.de/about-imb/ne...
