Elisabetta Mereu

Home – Cell Symposia: Decoding Cellular Complexity: Single Cell Biology in the Era of AI Cell Symposia: Decoding Cellular Complexity: Single Cell Biology in the Era of AI

Join us at Cell Symposia: Single-Cell Biology in the Era of AI (Dec 2–4, 2026, Munich) 🇩🇪

From multi-omics to AI-driven models of cellular dynamics — an exciting lineup across experimental & computational biology.

Hope to see you there!
🔗 www.cell-symposia.com/single-cell-...

Professors: we must start teaching the creative scientific process to PhD students and postdocs! Register for our April 24 train-the-trainer event in New York to learn from us how to teach it.
night-science.org/train-the-tr...
Register by Jan. 30th for a free Night Science Podcast T-shirt!

With all the excitement about AI giving us answers, we often forget that the real trick is to figure out what is the question.

ISCO (Innovations in Single-Cell OMICS) will be back in beautiful Barcelona!

🗓️ 28th/29th of May 2026
📍Barcelona Biomedical Research Park @prbb.org (beachfront!)

Keynotes: @bartdeplancke.bsky.social and @bocklab.bsky.social

Submit your abstract and present your research!

www.isco-conference.eu

@yusufroohani.bsky.social @rberrens.bsky.social @timcoorens.bsky.social @hsiuchuanlin.bsky.social @albarmeira.bsky.social @ferrannadeu.bsky.social @alejofraticelli.bsky.social @elimereu.bsky.social @simonhaas.bsky.social @leifludwig.bsky.social @stefaniegrosswendt.bsky.social

Not sure why @lpachter.bsky.social did not post this here. But it is brilliant. Single cell genomics finally makes it to the clinic.

🚀The Human Pancreas Atlas is here!
With profiles of >4M cells and nuclei from 57 donors, this outstanding work is part of the @humancellatlas.org, led by @bihatcharite.bsky.social and @elimereu.bsky.social, with contributions from @hoheyn.bsky.social (CNAG)

www.biorxiv.org/content/10.1...
#ESPACE

The Berlin crew Ashley Sanders @simonhaas.bsky.social @leifludwig.bsky.social @stefaniegrosswendt.bsky.social is passing the torch to our co-organizers and partners in crime @elimereu.bsky.social @larsplus.bsky.social @alejofraticelli.bsky.social for ISCO 2026 in Barcelona
www.isco-conference.eu

The Innovations in Single Cell Omics conference in Berlin was amazing! Great talks and we even had a Night Science workshop! 🙏 @stefaniegrosswendt.bsky.social, Ashley Sanders, @simonhaas.bsky.social, @leifludwig.bsky.social, @elimereu.bsky.social, @larsplus.bsky.social & @alejofraticelli.bsky.social

Meet Alessia Buratin 👩‍🔬

She focuses on Single Cell Multi Omics and Deep Learning Approach to reverse immunosuppression in Multiple Myeloma, under the supervision of Dra @elimereu.bsky.social at @carrerasijc.bsky.social.

Read about Alessia and her project: carrerasleaders.eu/postdoctoral...

Congrats Sergi, María & the whole team!

We're pleased to announce that Dr Ari Melnick has been appointed new Director of the Josep Carreras Institute.

Dr Melnick will lead IJC in our mission to advance #research in #leukaemia and other malignant blood diseases.

Read the full release here: www.carrerasresearch.org/en/news/dr-a...

Proud of our new perspective describing the role of mathematical biology for immunotherapy www.nature.com/articles/s41... @natbiotech.nature.com

Epigenetic enhancement of adoptive T cell immunotherapy www.cell.com/cancer-cell...

Ohh sure!! Nice to hear from you Davis! 😎

Protocol Optimization Improves the Performance of Multiplexed RNA Imaging Spatial transcriptomics has emerged as a powerful tool to define the cellular structure of diverse tissues. One such method is multiplexed error robust fluorescence in situ hybridization (MERFISH). ME...

www.biorxiv.org/content/10.1...

On my way to #Ascona in Switzerland) for this exciting congress, where we will discuss about modern benchmarking strategies to advance molecular biology!! Happy also to present our findings on the latest systematic evaluation of #singlecell multimodal data integrations in complex tissues. 🧬🔬👩🏻‍💻👩🏻‍🔬

Do we really know the impact of multiple single-cell data types? We often assume that single-cell sequencing gives us a complete picture of cellular diversity, but actually, we already saw in previous publications, like here and here, that one protocol is not reall...

🔬 Curious about the impact of #singlecell multimodal data on cell-type discovery? Check out our latest study: www.mereulab.org/post/do-we-r... .
📖 Too tired to read? No problem! 🎧 Listen to the NotebookLM #podcast included at the end of the post instead!

Join us at "Innovations in Single Cell Omics" in Berlin 5.12-13 (+ night science workshop!)
www.isco-conference.eu
Organizers:
@stefaniegrosswendt.bsky.social, @simonhaas.bsky.social
@leifludwig.bsky.social, Ashley Sanders, @larsplus.bsky.social, @elimereu.bsky.social, @alejofraticelli.bsky.social

@leifludwig.bsky.social @simonhaas.bsky.social @stefaniegrosswendt.bsky.social

ISCO - ISCO

🚀 Join the #ISCO2025 community at @mdc-berlin.bsky.social on May 12-13! 🚀
Don't miss this incredible opportunity to connect with top #singlecell & #spatial omics experts and participate in a special Workshop led by @itaiyanai.bsky.social.
⏳Abstract submissions: March 21)
www.isco-conference.eu

ISCO - ISCO

🚀 Join the #ISCO2025 community at @mdc-berlin.bsky.social on May 12-13! 🚀
Don't miss this incredible opportunity to connect with top #singlecell & #spatial omics experts and participate in a special Workshop led by @itaiyanai.bsky.social.
⏳Abstract submissions: March 21)
www.isco-conference.eu

📖 Too tired to read? No problem! 🎧 Listen to the #NotebookLM podcast at the end of the post here: www.mereulab.org/post/do-we-r...

Do we really know the impact of multiple single-cell data types? We often assume that single-cell sequencing gives us a complete picture of cellular diversity, but actually, we already saw in previous publications, like here and here, that one protocol is not reall...

🔬 Curious about the impact of #singlecell multimodal data on cell-type discovery? Check out our latest study: www.mereulab.org/post/do-we-r... .
📖 Too tired to read? No problem! 🎧 Listen to the NotebookLM #podcast included at the end of the post instead!

Systematic evaluation of single-cell multimodal data integration for comprehensive human reference atlas. The integration of multimodal single-cell data enables comprehensive organ reference atlases, yet its impact remains largely unexplored, particularly in complex tissues. We generated a benchmarking da...

Ever wondered why we do all these #Omics?
Here is your answer: biorxiv.org/content/10.1... 📜

Multi-Omics integration of a Human Cell Atlas
@humancellatlas.org of the Kidney, coordinated by the #HCA Standards and Technology Working Group and co-led by
@elimereu.bsky.social.

Led by @marioacera.bsky.social and #JessicaLi from my group @carrerasijc.bsky.social, alongside #XianAdiconis from #JoshuaLevin’s lab at @broadinstitute.org , and supported by many collaborators, this study is a multidisciplinary effort, bridging kidney biology, genomics, and computational science.

GitHub - mereulab/scOMM: Source code for scOMM Source code for scOMM. Contribute to mereulab/scOMM development by creating an account on GitHub.

✅ Introducing #scOMM, a new interpretable machine learning tool for multimodal cell-type classification & benchmarking.

github.com/mereulab/scOMM

✅ Quantitative evaluation of integration strategies for sn/scRNA- and snATAC-seq.
✅ Identifying rare & clinically relevant cell types, including WFDC2+ thick ascending limb and Norn cells (EPO-producing fibroblasts).
✅ Enhancing kidney disease trait heritability analysis.
And last but not least..👇

Our preprint provides essential guidance on multimodal #singlecell data integration and human organ atlas generation, using the kidney as a model system. Key insights 👇:

Systematic evaluation of single-cell multimodal data integration for comprehensive human reference atlas. The integration of multimodal single-cell data enables comprehensive organ reference atlases, yet its impact remains largely unexplored, particularly in complex tissues. We generated a benchmarking da...

🚀 New Preprint Alert! 🚀 With the Standards and Technology Working Group of the @humancellatlas.org, we present a new preprint guiding multimodal #singlecell data integration and human organ atlas generation! 📄
Read the preprint: www.biorxiv.org/content/10.1...