Ayusman Sen's Avatar

Ayusman Sen

@ayusmansen

Active autonomous systems; synthetic nano and micromotors; micropumps; nanotechnology, systems chemistry. https://sites.psu.edu/sengroup/ “It's tough to make predictions, especially about the future.” Yogi Berra

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14.11.2024
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Latest posts by Ayusman Sen @ayusmansen

You and Jack rock, my friend 👍

07.03.2026 22:24 👍 1 🔁 0 💬 1 📌 0
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So proud of him.

07.03.2026 19:38 👍 48 🔁 3 💬 2 📌 0
Nano-robots, Swarm Intelligence, Artificial Life & the future of healthcare: Prof. Ayusman Sen
Nano-robots, Swarm Intelligence, Artificial Life & the future of healthcare: Prof. Ayusman Sen YouTube video by Ones Changing The World - 1CW

My podcast interview on nanobots: www.youtube.com/watch?v=W38Y...

07.03.2026 22:14 👍 1 🔁 0 💬 0 📌 0
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Maxwell’s demon might lurk in enzyme behaviour The controversial process of enhanced enzyme diffusion could enable living systems to resist local equilibrium

Maxwell’s demon appeared to undermine the Second Law of thermodynamics by moving a system out of equilibrium. While there are flaws in that reasoning, enzymes may similarly help living systems to reach non-equilibrium conditions.

04.03.2026 15:27 👍 4 🔁 1 💬 0 📌 0

Always loved this album!

26.02.2026 02:04 👍 1 🔁 0 💬 0 📌 0
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Enhanced Diffusion of Single, Lipid-Tethered Enzymes Recent experimental evidence has shown that enzymes that catalyze exergonic reactions are able to diffuse faster during catalysis, a process called “enhanced diffusion”. If true, enzyme propulsion cou...

Nice work! Enhanced Diffusion of Single, Lipid-Tethered Enzymes | Nano Letters pubs.acs.org/doi/full/10....

22.02.2026 13:34 👍 1 🔁 0 💬 0 📌 0
A bearded man in nurse's scrubs offers aid to Justice, wearing a blindfold and holding a sword and scales, who has fallen to her knees.

A bearded man in nurse's scrubs offers aid to Justice, wearing a blindfold and holding a sword and scales, who has fallen to her knees.

Street art memorializing Alex Pretti in Seattle. Per r/Seattle, it was painted on a building facing Swedish Hospital in the First Hill neighborhood www.reddit.com/r/nursing/co...

27.01.2026 04:00 👍 8008 🔁 2509 💬 101 📌 92
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🧪🧠 New preprint out!
Soft Hardware, Flowing Software
We introduce reconfigurable microfluidics as an active control layer for chemical computation. Geometry, and flow, and not molecular redesign, programs function.
Great work by Piet!
chemrxiv.org/doi/full/10....

27.01.2026 13:37 👍 9 🔁 2 💬 2 📌 0
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Science and Industry Need to Push Back Hard - TimmermanReport.com The days of strongly worded letters, statements to the press, white papers, and op-eds are over. The people dismantling science are coming at all we care about with a pliers and a blowtorch. If I have...

Powerful call to action from @cdelawalla.bsky.social founder of @standupforscience.bsky.social

timmermanreport.com/2026/01/scie...

26.01.2026 18:16 👍 80 🔁 33 💬 1 📌 1
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Rest in Peace Alex Jeffrey Pretti🙏🏾 The VA ICU Nurses send him off right 💔

26.01.2026 05:04 👍 17719 🔁 6831 💬 317 📌 1131
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14.01.2026 18:21 👍 394 🔁 56 💬 7 📌 5
JACS Front Cover 
Vol 147/Issue 52
Week Commencing 29 Dec 2026

JACS Front Cover Vol 147/Issue 52 Week Commencing 29 Dec 2026

‘Droplets as Cell Models: Chemical Gradient-Induced Directional Filopodia Formation', has made it on the front cover of this week's #JACS!

Explore the research behind the art: buff.ly/s30uUR7

02.01.2026 13:00 👍 2 🔁 3 💬 0 📌 0
https://pubs.acs.org/toc/jacsat/147/52:

Droplets hunting for “chemical treasures”: oil-in-water droplets reshape in response to chemical gradients (from the glowing treasure chest), recapitulating how living cells detect and grow toward or away from environmental cues. By understanding the forces driving this behavior, the authors aim to build synthetic versions of cellular life and gain deeper insight into matter-to-life transitions.

https://pubs.acs.org/toc/jacsat/147/52: Droplets hunting for “chemical treasures”: oil-in-water droplets reshape in response to chemical gradients (from the glowing treasure chest), recapitulating how living cells detect and grow toward or away from environmental cues. By understanding the forces driving this behavior, the authors aim to build synthetic versions of cellular life and gain deeper insight into matter-to-life transitions.

🎉🎉The art I designed is now featured on the Front Cover of @jacs.acspublications.org!🎉🎉
Grateful to my mentor @ayusmansen.bsky.social for encouraging creative ways to illustrate our science.
Check out the article: pubs.acs.org/doi/10.1021/...

#ActiveEmulsions #SoftMatter #MatterToLife #ScienceArt

05.01.2026 21:10 👍 3 🔁 1 💬 0 📌 0
From Disappointing affirmations:

Do something nice for someone today.
Leave them alone.
Life is hard enough without your bullshit.

From Disappointing affirmations: Do something nice for someone today. Leave them alone. Life is hard enough without your bullshit.

Happy New Year
#disappointingaffirmations

01.01.2026 04:17 👍 110 🔁 13 💬 1 📌 0
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#NousICREAs2025 |💡@katherinevilla.bsky.social (@iciq.org) impulsa tecnologies sostenibles per afrontar els reptes ambientals i energètics globals.

Crea micromotors que es mouen amb llum i materials capaços de netejar contaminants i generar combustibles solars.

https://short.do/JYHhN1

31.12.2025 08:30 👍 5 🔁 3 💬 0 📌 0
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We are on the front cover of the last issue of 2026! Thanks to the artistry of @sanjanakmani.bsky.social
and thank you @pubs.acs.org
Droplets as Cell Models: Chemical Gradient-Induced Directional Filopodia Formation | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...

31.12.2025 15:00 👍 2 🔁 1 💬 1 📌 0
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@leecronin.bsky.social Are these droplets alive?

27.12.2025 14:51 👍 0 🔁 0 💬 0 📌 0

There’s the Indian doctors I know who voted for him because he’s ’a businessman’ and he would lower their taxes.
There are the Indians I know who voted for him because ‘the gay agenda in schools have gone too far’. There are the Indians who voted for him because he was going to ‘cut immigration’

22.12.2025 20:50 👍 26 🔁 5 💬 5 📌 0

Very cool! Suggests the possibility of intra-organelle navigation using pH gradients.

20.12.2025 13:42 👍 1 🔁 1 💬 0 📌 0
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Droplets as Cell Models: Chemical Gradient-Induced Directional Filopodia Formation Cells are complex chemical systems capable of sensing and responding to environmental cues by dynamically reshaping themselves, e.g., by forming arm-like protrusions such as filopodia. Recapitulating cellular behavior in artificial systems is a long-standing goal in understanding the matter-to-life transition and designing responsive soft materials. Here, we use oil-in-water emulsions that mimic cellular environmental sensing and form directional arm-like filopodia in response to external chemical cues. Our work analyzes the step-by-step process involved in the formation of artificial filopodia, and we engineer ways to direct filopodia growth through different chemical gradients. The process is driven by asymmetric surfactant partitioning across the oil–water interface, followed by ordering at the interface to form lamellar structures, which are projected out as filopodia. We observe filopodia growing away from the source of kosmotropic anions and toward the source of chaotropic anions from the Hofmeister series. Significantly, these systems also respond to amino acid gradients, similar to cells: tryptophan gradients favor growth toward the source, while lysine and arginine gradients cause growth away from the amino acid source. Our findings open new avenues for fabricating life-like materials that sense and grow in response to external signals.

@acs.org has posted a Research Headline Video on our paper: www.youtube.com/shorts/LPFlI...
Droplets as Cell Models: Chemical Gradient-Induced Directional Filopodia Formation | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...

10.12.2025 00:26 👍 3 🔁 0 💬 0 📌 0
Collette Delawalla, chief executive and founder, Stand up for Science, Decatur, Georgia.  She has been focusing on building resistance to the US Government's targeting of the nation's scientific enterprise ahead of the 2026 midterm elections. 

From Nature

Collette Delawalla, chief executive and founder, Stand up for Science, Decatur, Georgia. She has been focusing on building resistance to the US Government's targeting of the nation's scientific enterprise ahead of the 2026 midterm elections. From Nature

🧵Congrats to @standupforscience.bsky.social activist and leader @cdelawalla.bsky.social for being named one to watch in science by Nature. The world’s leading science journal!

Well deserved!

www.nature.com/immersive/d4...

09.12.2025 03:13 👍 208 🔁 64 💬 3 📌 5

As with Shakespeare, I always found myself coming out of a Stoppard play feeling more intelligent than when I went in.

02.12.2025 15:02 👍 42 🔁 5 💬 0 📌 0

Biological organisms exhibit purposeful behavior that allows them to survive and persist. They can also be described as material patterns maintained by flows of energy and information. When and how do the concepts of agency and purpose emerge as meaningful descriptors of certain material systems?

26.11.2025 14:12 👍 1 🔁 0 💬 0 📌 0

@philipcball.bsky.social @andrewbissette.bsky.social Is replication a strict requirement? What about a system that responds to the environment in ways that furthers its persistence. Does it not have "agency"? Is it alive?

26.11.2025 14:08 👍 2 🔁 0 💬 2 📌 0
Make your donation now - Wikimedia Foundation Donate to the Wikimedia Foundation, the nonprofit that hosts Wikipedia and other crucial free knowledge projects. Each year, the generosity of the 2% of readers who donate allows us to expand the reac...

Wikipedia is 25! If you use it all the time and want to protect a future where knowledge is human-made, join me and donate now: donate.wikipedia25.org #Wikipedia25

25.11.2025 19:36 👍 1 🔁 0 💬 0 📌 0

Me too!

16.11.2025 01:40 👍 0 🔁 0 💬 0 📌 0
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U.S. Congress considers sweeping ban on Chinese collaborations Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students

“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”

14.11.2025 01:03 👍 591 🔁 308 💬 57 📌 276

RIP Jim Watson. You inspired many of us to pursue a life in research. I wish you had made it easier for us to celebrate your legacy.

07.11.2025 23:11 👍 64 🔁 7 💬 2 📌 0

Congratulations, Job!!

06.11.2025 17:35 👍 1 🔁 0 💬 0 📌 0

Congratulations, @sanjanakmani.bsky.social! Nice work!

03.11.2025 19:48 👍 1 🔁 0 💬 0 📌 0