We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it.
A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !
"we propose that the protoribosome was a parasite (...). If this view is correct, then like the spliceosome in the stem eukaryote, a repurposed host-parasite interaction led to a dramatic change in cell biology at the base of the tree of life, in this case leading to the exit from an RNA world"
Paper alert from @codyz.bsky.social y.social and Yang Liu. New mechanism for chromatin remodeling by ATRX. Super cool story. Congrats to #lugerlab alumni.
www.biorxiv.org/content/10.6...
We wrote a perspective "How to build the regulatory genome: a constructionist guide to the cis-regulatory code", out in Development yesterday. Title says it all. Find it here:
journals.biologists.com/dev/article/...
DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!
🤩💪 Out now! 3D regulatory hubs in sex determination
With @mamartirenom.bsky.social & Capel labs, led by @imotagom.bsky.social & @jrotwitguez.bsky.social
1️⃣ METALoci – explore #3DGenome 🧬
2️⃣ Non-coding region controlling Fgf9 🧩
3️⃣ Meis genes = new key players 🌟
👉 rdcu.be/e5sm2
1/n Bluetorial 👇
🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41...
RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP
Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.
..and the Cook with the suppurating wound to put us off.
They dangled the wife of Bath’s tale to lure us in.
Who knew that the ability to handle belligerent, incoherent people is a key to Congressional success?
Ethel Merman volume.
💯Jim Webb wannabe
..also, who is this increased capacity for?
“experience” is the #1 enemy of these times. #Lysenko
*Council* on Foreign Relations.
Maybe worth noting the history of members of the Consul on Foreign Relations
Hilarity should sue for damages 😉
They seem to lack character or identity, hence the image-chasing.
Not a single shared value among them.
🎯 ’conductivity probe’ listed on the order also suggests this.
Unless you’re buying deep-discount books at Costco 😉
‘Bubble Trump’
The amount of exposure of the victims vs perpetrators is too high & counting with each release.
🎯
yes, there’s that 😉
RFK Jr. has the dietary discrimination of a seagull at low tide.
Remove ‘Black history’ from the shortest month of the year while removing Black history from America’s historical markers. ‘Mission Accomplished’
