📢Out now! @codingfisch.bsky.social and colleagues present deepmriprep, a tool that leverages neural networks to enable 37x faster Voxel-based Morphometry preprocessing of MRI data than existing methods. www.nature.com/articles/s43... #compneurosky
Check out this new tool to conduct reliable VBM MRI preprocessing in 10 seconds🧠📢
Congrats to my brilliant colleague @codingfisch.bsky.social for this great tool and publication!
📢 PhD position in this project open now!
Interested in the causal role of brain changes in depression?
Apply here: jobs-sf.ukmuenster.de/job/UKM-Dokt...
Please share and spread the word🎓
The journal is diamond open access, meaning free to read and free to publish
So excited to share the launch of a multi-disciplinary journal dedicated to replications and other meta research!🚀 It has been super interesting to be involved in this project and I can't wait for the first submissions!
replicationresearch.org
#openscience #neuroscience #metaresearch
🎓 Stay tuned for upcoming PhD position opening if you are interested to learn about depression, neuroimaging and causal inference
What causal role do brain changes play in depression?
New EKFS-funded 4-year study will tackle this question leveraging a unique longitudinal MRI datasets – up to 9 scans per patient across 16 years!
#Neuroimaging #Depression #Causality @traplabms.bsky.social @ekfstiftung.bsky.social
🔍 Have we solved the replication crisis?
Join us for an IGOR panel discussion on the state of Open Science in biological psychology more than a decade after the crisis first hit.
📅 Friday, 10 Oct | 10:00–11:00 CET
💻 Online (contact us for the link)
#OpenScience #neuroskyence #academicsky
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Can brain organoids become conscious? A new paper argues it’s unlikely with today’s tech, but urges ethical debate as research advances.
www.cell.com/patterns/ful...
#neuroscience #organoids #consciousness #bioethics
How does the brain decide? 🧠
Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.
After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.
rdcu.be/eGUrv
🧠 The #MICrONS project just released the most detailed brain map ever—82K neurons, 523M synapses, all open for exploration. Dive in thanks to #BossDB: github.com/aplbrain/bos...
#Neuroscience #OpenScience #Connectomics #3DThursday #syGlass @alleninstitute.bsky.social @jhuapl.bsky.social
NEW Journal Article: "The Economic Impact of Open #Science: A Scoping Review" https://www.infodocket.com/2025/09/17/journal-article-the-economic-impact-of-open-science-a-scoping-review/ #openscience #os #oa #oss #ofd
I'd be happy to but unfortunately, the availability of pediatric samples is limited at our lab. We are currently conducting a series of direct replications but mostly with adult samples so far. However, I would love to expand this to other labs and datasets if you are interested
📣 Attending #ICON2025?
Don’t miss this symposium today at 13:45!
Featuring @alinakoppold.bsky.social who will present an ongoing IGOR project: "From Raw to Refined: How Data Transformations Shape Effect Sizes and Reliability"
#openscience #neuroskyence
Inter-individual variability of neurotransmitter receptor and transporter density in the human brain | bioRxiv www.biorxiv.org/content/10.1...
What prevents suicide in #bipolar disorder?
Lithium, then to a lesser degree valproate, but not antipsychotics (unless as augmentation), concludes new cohort study of 44,694 from Korea:
pubmed.ncbi.nlm.nih.gov/40930182
Evidence grade: Low (4/10)
chrisaikenmd.com/ebm/
#psychiatry
Strategies for effective coding agent usage - the latest in my Better Code, Better Science series russpoldrack.substack.com/p/strategies...
🚨 New paper in @npp-journal.bsky.social! We combined data from 3 studies (including an SSRI RCT) to explore how endocannabinoids relate to anxiety & treatment response in kids + teens. Team science w/ Jeanne Barcelona, Jeffrey Strawn & more!
www.nature.com/articles/s41...
@wsuthinklab.bsky.social
Happy to share our recent work attempting to better understand the impact of early life maternal separation on locus coeruleus function. Super proud of first author (the now Dr.) Chayla Vazquez. She brought this idea when she joined in… March 2020… and she carried it through these rough few years!
Just a friendly reminder to check who owns the preprint servers that you are using and to choose a non-commercial one: en.wikipedia.org/wiki/List_of...
Huge thanks to all involved, including: @smeinert.bsky.social @kflinkenfluegel.bsky.social @lisaleehr.bsky.social @jboehnlein.bsky.social @mariusgruber.bsky.social @kabro.bsky.social @vincenthammes.bsky.social @straubeb.bsky.social @nilsopel.bsky.social and everyone at @traplabms.bsky.social
Our work adds to previous prominent contributions that question replicability in neuroimaging (e.g., @smarek0502.bsky.social and @tervoclemmensb.bsky.social in @nature.com - doi.org/10.1038/s415...)
The original finding of gray matter correlates of maltreatment has been published numerous time and is often described as established. Our consistent null results challenge that view and raise broader questions: how replicable are results in mental health neuroimaging?
Similar results were seen when rerunning all analyses using parcellation-based measures of regional cortical thickness/surface and subcortical volumes
Largest effects were found in models including HC and MDD groups while not controlling for diagnostic group (model 2 and 13) but disappeared when diagnosis was accounted for
The significance of voxel overlap (i.e., replicability) was tested using permutations, resulting in no above-chance replicability across any pairwise or triple-wise cohort combination in any analysis (also when using p<.01 uncorrected)
Replicability was defined as the same voxel showing significance across cohorts. At p<.001 uncorrected (a liberal significance treshold for voxel-wise data) only two analyses resulted in minor overlap - k=2 and k=3 voxels. My personal favorite results item, Table 3:
We ran over 100 analyses in each of the 3 cohorts:
➡️different maltreatment operationalizations (subtypes, severe forms, etc)
➡️healthy and clinical (MDD) subsamples
➡️varying inclusion of confounders (diagnosis)
➡️sex-stratified analyses
➡️different gray matter methods (VBM and parcellation-based)
Link to the Open Access paper📃: rdcu.be/eGGc1
Open code is provided
