Agnese Cristini

Very happy to have participated to this nice work!

Congratulations to first author @raphaelmngn.bsky.social and many thanks to all our great collaborators 🧑‍🎓 - Rodney Rothstein @columbiamed.bsky.social, Sergio de Almeida @gimmfoundation.bsky.social, Peter Stirling @BCCancer and Pierre-Henri Gaillard @crcm.bsky.social (6/8)

Save the date! On March 25th, We'll dive into Nanofluidic tools for studying DNA repair with Fredrik Westerlund and R-loops & genome instability with Sidrit Uruci & Agnese Cristini. Don't miss out! 🗓️ #DNARepair #GenomeStability

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this!

So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!

www.cell.com/molecular-ce...

Congrats !!

❗️Our new paper "Local activation of Cxcl12a signaling controls olfactory placode morphogenesis in zebrafish embryos" is out 👇
bioRxiv.🙏 Thanks so much to all coauthors: fantastic people😍🤩 ✨️fantastic work. Mathematical modeling to understand morphogenesis. Get in touch if interessed, more to come😉