Cover of the Journal of Psychiatry and Neuroscience featuring a glowing brain scan highlighting neural pathways in red and white.
Our most read 2025 article explores AI-generated teaching signals in psychiatry, helping clinicians sharpen clinical sense-making. Read it now ▶️ https://ow.ly/I57u50XWp65
👥 Lena Palaniyappan, Priyadharshini Sabesan
#BestofCSP
Screen shot from webpage showing Dr. Palaniyappan with title "A Canadian scientist is shaking up the way we think about mental illness"
The Mach-Gaensslen Foundation of Canada is happy to announce the 2025 winner of the Royal-Mach-Gaensslen Prize for Mental Health Research. This year's recipient is Dr. Lena Palaniyappan with the Douglas Mental Health University Institute in Montreal.
www.theroyal.ca/news/dr-lena...
Kick off the new year with the Neurogenesis Speaker Series! 🎤🧠
Join Manuela Ferrari & @lenapl.bsky.social at @theneuro.bsky.social on Jan. 21, 2026, for two exciting talks on their research in mental health, followed by a meet-and-greet reception. 🧀
🫵 Register now: mcgill.ca/x/5kz
@mcgill.ca
Quantitative semiology: harnessing AI-generated teaching signals in psychiatry cdnsciencepub.com/doi/10.1139/...
New review paper on theory of mind/mentalizing and spontaneous speech/language. Led by Chaimaa El Mouslih, and co-authored with @vegashodgins.bsky.social and @lenapl.bsky.social
www.mdpi.com/2076-328X/15...
Check out this 🆕 paper form @lenapl.bsky.social et al showing that speech spectrograms can track negative symptom severity in schizophrenia
www.nature.com/articles/s44...
🚨 NEW RESEARCH! ⚕️ 🩺 🧠
Elleuch et al. explore the association of grammatical challenges in people with Schizophrenia in a systematic review and meta-analysis of 45 studies.
https://bit.ly/4kZnq66
@lenapl.bsky.social
One of the largest longitudinal study of computational speech and language features and psychosis from @stanglab.bsky.social Tang & colleagues! www.nature.com/articles/s44...
#ThisWeekInNPP
This study identified a prefrontal-limbic structural covariance network with ⬇️ gray matter volume specific to treatment-resistant schizophrenia, linked to serotonergic, glutamatergic, histaminergic, & opioid receptor distributions 🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
People with schizophrenia that is resistant to treatment may have specific prefrontal-limbic brain deficits linked to non-dopaminergic neurotransmitter systems—highlighting the need for therapies beyond antipsychotics. #schizophrenia #neuroscience #mentalhealth
Very, very obviously we need to emphasize science-informed preventative strategies.
Public health experts – myself included – have focused on this for decades!
But phrase "root causes" long ago morphed into a red flag for bunk. 🚩
news.immunologic.org/p/real-root-... @drandrealove.bsky.social👇
Congratulations to @lenapl.bsky.social, @sylvainbaillet.bsky.social and the whole team on the boost from the @wellcometrust.bsky.social for the DIALOG initiative douglas.research.mcgill.ca/news/underst...
Drs. Peter Van Dyken and Lena Palaniyappan (@lenapl.bsky.social) (@schulichmeddent.bsky.social)'s research trainee study on graph theory and U-fibre network in people with #Schizophrenia: www.psifoundation.org/funded-resea... #SchizophreniaResearch
Excellent synergy here, looking forward to it @sylvainbaillet.bsky.social !
Western University is seeking applications for Canada Excellence Research Chairs. Please reach out if you are interested in Theme 2: Neuroscience. Western has extraordinary strengths in cognitive, molecular and systems neuroscience across species (rodents, NHPs, humans) uwo.ca/research/cer...
It will be interesting to see CPC vote density mapped on measles outbreaks.
Researchers are a group that can take concrete steps to reduce the environmental footprint associated with their activities while continuing to improve human health outcomes through their research. Editorial: Greening the lab: fighting climate change to enhance mental health. Albert et al. J Psychiatry Neurosci April 23, 2025 50 (2) E142-E144; DOI: https://doi.org/10.1503/jpn.250040
Greening the lab:
Researchers are a group that can take concrete steps to reduce the environmental footprint associated with their activities.
➡️
www.jpn.ca/lookup/doi/1...
Topiramate is effective in treating compulsive behaviours associated with PWS, but requires monitoring for hyperammonemia and psychiatric comorbidities. Psychopharmacology for the Clinician: Effectiveness of topiramate in the treatment of behavioural disorders in Prader–Willi syndrome. Louveau et al. J Psychiatry Neurosci April 23, 2025 50 (2) E145-E146; DOI: https://doi.org/10.1503/jpn.240107
Topiramate for treatment of behavioural disorders in Prader–Willi syndrome:
Topiramate is effective in treating compulsive behaviours associated with PWS, but requires monitoring.
➡️
www.jpn.ca/lookup/doi/1...
📣 We are proud to announce that the Wellcome Trust has awarded Dr. Palaniyappan!
📣 Nous sommes fiers d’annoncer l'obtention d'une subvention de la Fondation Wellcome Trust à Dr Palaniyappan pour soutenir le projet DIALOG!
More infos / plus d'infos :
douglas.research.mcgill.ca/news/underst...
We show cannabis use disorder is associated with higher midbrain neuromelanin, where such an increase is associated with #psychosis severity. The higher the use, the greater the putative dopamine turnover.
Led by Jessica Ahrens @healthsciences.mcgill.ca IPN
jamanetwork.com/journals/jam...
When we are depressed, we not only have negative thoughts but also experience a muddled, disorganized thinking process. We propose some steps to make progress in understanding and reducing the burden of disorganization in #Depression
link.springer.com/article/10.1...
www.sciencedirect.com/science/arti...
We see a prominent excess of first-person pronouns in #schizophrenia, with no excessive inter-individual variability. While not a direct comparison, this effect (d=0.89) is >> than striatal dopamine excess or prefrontal glutamate reduction reported to date.
please add me, thanks!
Don't give the same speech this year too. Tired of listening to it nine times in a row.
