Holger Klein

Dissecting the importance of the murine GCGR vs the GLP-1R for the CNS and #weightloss actions of survodutide @MolMetab www.sciencedirect.com/science/arti...

Saturday evening project: replacing the battery of my #vintage #synthesizer #ensoniq VFX-SD from 1989. Battery soldered to the board… now ready for action again. This model was used by bands like #depechemode, #neworder, #front242.

Thanks a lot, I'll have a look into the liposensitive switch paper as well :-)

This prevents the "forever-on" problem of traditional gene therapy, ensuring the treatment is only active when needed and can be instantly stopped if side effects occur.

For the readers outside this field of work: #Riboswitches might offer a way to make #genetherapy safer: They could act as precise "control knobs" for #genetherapy, allowing doctors to turn a therapeutic gene ON or OFF simply by having the patient take a specific, safe pill.

Small Molecule-Controlled Gene Expression: Design of Drug-like High-Affinity Modulators of a Custom-Made Riboswitch Riboswitches are regulatory RNA structures that modulate gene expression in response to a small molecule. Until now, most efforts to design ligand analogs were motivated by their potential antibiotic ...

Paper alert, some news on our #syntheticbiology activities. You can find out paper on the TPP #riboswitch activator at pubs.acs.org/doi/10.1021/.... And even better, you can order the compound for free on #boehringer 's #opnMe platform at www.opnme.com/molecules/tp....

#science

Moon through the clouds

#moon through the #clouds yesterday evening. It was cold (-7degrees C) and only had my cellphone with me, would have been a good opportunity to take some more #photos.

I just wish I knew which part is causing problems… I’ll spend another evening on it soon.

Another challenge: the tape drive seems to have some mechanical problems, and on top, I don't have software. As far as I read, it should be possible otherwise to put audio files to tapes and use them...

And this is close enough to the #commodore world, but it is said to be richer in comparison. But since I got it by chance many years back, and never looked into it, not much experience to do more interesting stuff with it.

Upon start, one is greeted by CAOS, the cassette assisted operating system. One can choose BASIC...

More #retrocomputing. Played around again with the #KC85/4 from #robotron, that was collecting dust. Built in the #GDR/#DDR between '84 and '88, it has a #U880 as a CPU. This is an unlicensed clone of the Zilog #Z80, produced by the VEB Mikroelektronik „Karl Marx“.

It has a #mos6509 cpu and 128kb of RAM. The version with built in floppy disks is said to rare. Serial number 2580 :). #retrocomputing

Trying to fix my old #cbm710. A #commodore machine from the early 80s, #BASIC very similar to what I knew from the #c64, had programmed a nice screensaver for it. Unfortunately stopped to work some time ago. First attempt unsuccessful…

Photo from the milky way

clear #sky tonight - a bit of the #milkyway from the garden just taken on the cellphone #bluesky #photography

#flamingos in #deltadelebre in #catalunya. #nature #photography

#dragonfly in #deltadelebre in #catalunya. #photography #nature

#photo of full #moon rise in catalunya / #medieranean sea #nikon z6II at 200mm f6.3 1/10sec / 9.8.2025

So happy to have seen #HerbieHancock in #Munich yesterday evening. Great band and great set covering many of my favourite albums, quite a lot of weight on the 70s. One of the big influences on my #music taste.

Abundance of a metabolically active subpopulation in dedifferentiated adipocytes inversely correlates with body mass index. The cellular composition and functionality of adipose tissue are key determinants of metabolic diseases associated with adipose tissue dysregulation, …

Happy to share the outcome of one of our #collaborations in the #obesity space - #publication of Jonathan Trujillo Viera et al - check it out: www.sciencedirect.com/science/arti...

Some #berlin impressions. Always great to be back and meet old friends and former colleagues. #photography #urban

Scientific Director Computational Chemistry (m/f/d) Scientific Director Computational Chemistry (m/f/d)

Are you a passionate drug hunter and an inspirational leader with a background in computational chemistry? So you want to make a difference in cancer research?

Then this could be for you: jobs.boehringer-ingelheim.com/job/Vienna-S...

#ChemJobs #EuChemJobs #ChemSky #CompChem

Principal Scientist - Medicinal Chemistry Animal Health Principal Scientist - Medicinal Chemistry Animal Health

We are searching for an experienced Medicinal Chemist in Biberach, Germany. The position is located in a small, agile team focusing on Animal Health (as part of a larger MedChem department).

You might have to listen to my synthesis ideas. 😀

#ChemSky

jobs.boehringer-ingelheim.com/job/Biberach...

Looking for a #datascience / #drugdiscovery #postdoc on the interface between academia and industry? Check this out: ventures.yale.edu/news/applica...

Ice needles on twigs

Pictures taken already three weeks ago, but not unlikely we’ll see something similar this weekend.
#iceneedles #frost #photography

Principal Scientist Oncology RWD Analysis (m/f/d) Principal Scientist Oncology RWD Analysis (m/f/d)

* Real Word Data / Oncology (Vienna/Austria) - jobs.boehringer-ingelheim.com/job/Vienna-P...
* Application Landscape Owner/Data&Infrastructure (Vienna/Austria) - jobs.boehringer-ingelheim.com/job/Vienna-A...

Senior / Principal Scientist - Omics Engineering Senior / Principal Scientist - Omics Engineering

A few job openings in the CompBio and Digital Sciences Department at Boehringer:
* Omics Engineering (Biberach/South of Germany) - jobs.boehringer-ingelheim.com/job/Biberach...
* Senior Data Scientist (Biberach/South of Germany) - jobs.boehringer-ingelheim.com/job/Biberach...

Thank you, very interesting!

:-D

Didn't check the other genes, but TRPM6 is an ion channel involved in Mg homeostasis... I don't get the cat hint yet, though.