Sandeep Gupta

having a blast attending #CMMDR2026 at shiv nadar university, delhi. So many wonderful regeneration biology talks from around the world- from spinal cord injury regeneration to octopus regeneration.

Whole-cortex in situ sequencing reveals input-dependent area identity - Nature BARseq interrogates the expression of 104 cell-type marker genes in 10.3 million cells over nine mouse forebrain hemispheres to reveal the role of peripheral inputs on cortical area development.

Still think brain regions don’t exist? That everything is everywhere? That cell types don’t matter and that everything is a dynamical phase portrait?

Wrong.

Interconnected brain modules exist at the level of fine grained transcriptomics. www.nature.com/articles/s41...

Volume 152 Issue 20 | Development | The Company of Biologists

Development that lasts a life time. Check out the 2025 special issue of @dev-journal.bsky.social on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues

journals.biologists.com/dev/issue/15...

what an ending with iNeurons by Dr. Carol Schuurmans. it was a great experience witnessing cutting-edge stem cell research in Canada. Next Vancouver! #TMM2025

The ISSCR and Stem Cell Network Launch Global Regenerative Medicine Workforce Development Initiative — International Society for Stem Cell Research The International Society for Stem Cell Research (ISSCR) and the Stem Cell Network (SCN) are pleased to partner to lead a joint initiative and a global conversation on workforce development in regenerative medicine. Through this collaboration, the organizations will examine current challenges and op

ISSCR & Stem Cell Network are seeking nominations to form a working group of early career scientists & senior trainees in stem cell & regenerative medicine research who will provide perspectives on global workforce development. Nominations are due 5 December. Learn more 👉https://ow.ly/j8uY50Xnlzc

Exciting keynote talk at #TMM2025 by Christine Mummery on modeling arrhythmia using stem cell- derived cardioids!

spot on! 🤣

Gupta Lab's image of stem cell- derived neuroepithelium is displayed at #TMM2025. didn't win though 😭 congratulations to all the winners, beautiful pics of wonderful world of stem cells.

great start of day 3 at #TMM2025 with a talk by Neurona therapeutic on major advances in epilepsy treatment with stem cell- derived interneurons! things are getting excited!

Ramping up cortical activity in early life sparks autism-like behaviors in mice The findings add fuel to the long-running debate over how an imbalance in excitatory and inhibitory signaling contributes to the autism.

Great coverage by @thetransmissions.bsky.social of our latest preprint: adding new evidence (and a hint of controversy 🙂) to the E/I imbalance debate in autism
👇👇
www.thetransmitter.org/spectrum/ram...

great day-2 morning at #TMM2025, listening to an amazing story from Dr. Cristina Nostro, finding roles of macrophages in hsc- derived islet cell differentiation that can revolutionize future diabetes treatments. Huge congratulations to Dr. Nostro for receiving TMM2025 Till & McCulloch prize!

#TMM2025

very interesting talk by Ross Fitzsimmons from @ucalgary.bsky.social on raindeer antler regeneration and lessons for regenerative biology.

that was a crazy (awesome) result! seeing Melinda
myelination in the organoids, what's next? #TMM2025

excited to hear some cool science! #TMM2025

2025 Till & McCulloch Meetings

🎉 #ICYMI: New speakers announced for #TMM2025!

Join us in Ottawa to hear from Dr. Maria Cristina Nostro, 2025 Till & McCulloch Award recipient, and Brandon Murareanu, Drew Lyall Award winner, as they share groundbreaking #RegenerativeMedicine research. 🔬

Don’t miss it. ➡️ www.tillandmcculloch.ca

Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...

Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social

We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇

www.biorxiv.org/content/10.1...

Comparative analysis of human and mouse ovaries across age The mouse is a tractable model for human ovarian biology, however its utility is limited by incomplete understanding of how transcription and signaling differ interspecifically and with age. We compar...

And the open access article in Science
#ReproSky 🧪 #ReproMed #ObGynSky
www.science.org/doi/10.1126/...

A high-coverage genome from a 200,000-year-old Denisovan Denisovans, an extinct sister group of Neandertals who lived in Eastern Eurasia during the Middle and Late Pleistocene, are known only from a handful of skeletal remains and limited genetic data, incl...

A hearty Denisovan stew ripe with stories of mixing and more mixing, even with a third more ‘archaic’ hominid.

www.biorxiv.org/content/10.1...

Early career group leaders We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

Staff Scientist About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...

I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

first lab meeting of the Gupta lab! very fun start. We are building functional stern cell models to investigate neural disorders like autism.

The functional landscape of the human ubiquitinome Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...

new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...

Valuing disability and difference in society Those sitting at the decision-making and policy tables are far removed from the day-to-day experience of children, youth and their families.

At a time when there is so much discourse and rhetoric against disability, some thoughts here from a few months ago: www.thespec.com/opinion/cont...

Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems

I know the news is tough right now.

So take a moment and soak in the gorgeousness & promise of the science that led to this year’s Nobel Prize in Medicine & Physiology.

WOW.

www.nytimes.com/2025/10/06/h...

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial

Dense longitudinal neuroimaging reveals individual brain change trajectories Longitudinal measurements of brain structure and function are critical for understanding how humans change over time. Traditional longitudinal approaches sample sparsely across large windows of time t...

Dense longitudinal neuroimaging reveals individual brain change trajectories: Trends in Cognitive Sciences www.cell.com/trends/cogni...

I am going to repost our job ad because we are not getting many applicants!
Like anywhere, there are pros and cons, so if you have questions just DM or email me.
#academicjobs #neuroskyence #neuroethology #academicsky

Our calcium paper is out in PLOS Biology!
Check it out! #Calcium #Embryo #Development

Identification of a resistance-exercise-specific signalling pathway that drives skeletal muscle growth - Nature Metabolism This study demonstrates that the MKK3b/6 signalling pathway drives the skeletal muscle growth-promoting effects of resistance exercise.

www.nature.com/articles/s42...