Noam Shemesh

fMRI connectivity is dominated by recurring high-amplitude BOLD events (CAPs, QPPs)
But what originates these events? Many think neuromodulation is the culprit. Our new work offers a simpler take: cortico-cortical dynamics alone can generate CAP-like events! doi.org/10.1371/journal.pcbi.1013995
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RECRUITING!

Candidates from all related fields who are passionate about interdisciplinary research, cutting-edge neuroimaging and brain biophysics are especially encouraged to apply (contact noam.shemesh@weizmann.ac.il). Prior Experience with preclinical MR or functional optics is a plus.

I am establishing my new lab at Weizmann Institute (www.weizmann.ac.il/chembiophys/...) and am recruiting at the Senior Intern/Staff Scientist track, & at the Postdoctoral, PhD, MSc, and Technician levels. All positions are fully funded- I warmly welcome applications from outstanding candidates.

New website! still a bit rudimentary, but hopefully will be updated soon! :-)

Stay tuned for job postings (in the meantime you can check the "join us" tab if you are interested!)

www.weizmann.ac.il/chembiophys/...

Come work with us. Huge strengths in MRI, neuroscience and musculoskeletal health and their intersections such as pain, child development or ageing. Preclinical and clinical research and translation are also big opportunities. Shoot me a note if you have questions.

The ultrahigh field 18 Tesla @brukercorporation.bsky.social MRI Scanner has just arrived to @champalimaudr.bsky.social! Along with its cryoprobes, it is expected to be the most powerful preclinical scanner in the world. Ramping up will take time... will keep you posted!

@champalimaudf.bsky.social just installed a custom-built 18-Tesla horizontal-bore MRI scanner – the strongest for in-vivo imaging – to advance preclinical research non-invasively in neuroscience and cancer.
Full story: shorturl.at/pGREa

#PreclinicalResearch #Neuroscience #Cancer #MedicalImaging

The paper demonstrating that #psilocybin alters contextual computations is out in @natcomms.nature.com : doi.org/10.1038/s414...

Thanks to the reviewers and coauthors : @marcoaqil.bsky.social , @tknapen.bsky.social , @gillesdehollander.bsky.social , and Nina Vreugdenhil

Increased striatal coupling one week after ischemic stroke revealed by ultrafast functional MRI Background: Network reorganization following ischemic stroke is thought to play a role in recovery. Although cortico-cortical reorganization is widely established, changes in interhemispheric striatal...

New preprint from the lab on stroke and oscillations detected via ultrafast fMRI!

www.biorxiv.org/content/10.1...

Ramping up cortical activity in early life sparks autism-like behaviors in mice The findings add fuel to the long-running debate over how an imbalance in excitatory and inhibitory signaling contributes to the autism.

Great coverage by @thetransmissions.bsky.social of our latest preprint: adding new evidence (and a hint of controversy 🙂) to the E/I imbalance debate in autism
👇👇
www.thetransmitter.org/spectrum/ram...

Unlike the heart attack of getting a “Decision” email, it’s such a good feeling to get a “Your review is ready” email from qed :)

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

Tried this on a very technical fMRI manuscript with neuroscience applications. It warned me that neuroses outside its core expertise, but then proceeded to present an amazing analysis of the claims in the paper. Vastly superior to ChatGPT for example. I am impressed!

The things we can do @westernu.ca thanks to platform support grant funding from @braincanada.bsky.social And #NFRF

Authors retract Science paper on controversial fMRI method Several MRI artifacts contribute to the neuronal activity signal picked up by the method, according to a preprint the authors posted this month.

Even though the controversial DIANA method didn’t pan out, neuroimaging researchers still hold out hope to one day measure neuronal activity using fMRI.

By @callimcflurry.bsky.social

www.thetransmitter.org/retraction/a...

New paper in Imaging Neuroscience by Roza G. Bayrak, Catie Chang, et al:

DeepPhysioRecon: Tracing peripheral physiology in low frequency fMRI dynamics

doi.org/10.1162/IMAG...

A non-invasive approach to awake mouse fMRI compatible with multi-modal techniques Abstract. Mouse functional magnetic resonance imaging (fMRI) studies contribute significantly to basic fundamental and translational neuroscience research. Performing fMRI in awake mice could facilita...

A new open source nonsurgical head restraint for awake mouse fMRI from our lab led by Sam Laxer. TL;DR Scanning about 25% longer than with a surgically implanted head post, combined with some training gives good results. Happy mice = happy rsfmri networks. direct.mit.edu/imag/article...

Authors retract Science paper on controversial fMRI method Several MRI artifacts contribute to the neuronal activity signal picked up by the method, according to a preprint the authors posted this month.

Science is self correcting. Finally!

Authors retract Science paper on controversial fMRI method Several MRI artifacts contribute to the neuronal activity signal picked up by the method, according to a preprint the authors posted this month.

A method for capturing neuronal activity using fMRI excited the neuroimaging field but couldn’t be replicated. Today, the authors of the original paper retracted their work.

By @callimcflurry.bsky.social

#neuroskyence

www.thetransmitter.org/retraction/a...

Authors retract Science paper on controversial fMRI method Several MRI artifacts contribute to the neuronal activity signal picked up by the method, according to a preprint the authors posted this month.

An important retraction of the DIANA paper. Scientific progress is often made by correcting prior efforts, and here the community played its part efficiently. While this particular form of mapping neural activity was unsuccessful, the search continues!

www.thetransmitter.org/retraction/a...

New paper in Imaging Neuroscience by Marie E. Galteau, Joanes Grandjean, et al:

Activation mapping in multi-center retrospective rat sensory-evoked functional MRI datasets using a unified pipeline

doi.org/10.1162/IMAG...

Functional MRI reveals subcortical auditory push-pull interactions requiring intercollicular integrity Abstract. The role of subcortical structures in binaural integration is of great interest for auditory processing. The inferior colliculus (IC) is the main auditory midbrain center where ascending and...

direct.mit.edu/imag/article...

NEW PAPER!
After many years in the making... we present evidence that BOLD-fMRI can detect push-pull interactions in subcortical areas. Congrats to Frederico Severo and Mafalda Valente!

More fields need to do this.

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Another new paper from the Lab, with a multimodal fMRI / CBF / cFOS approach in an animal model of Parkinson's Disease!

Congrats @ruxandalungu.bsky.social @ciscaff.bsky.social, Sara Monteiro and our great collaborator Tiago Monteiro!

journals.sagepub.com/doi/10.1177/...

Evidence for a push-pull interaction between superior colliculi in monocular dynamic vision mode - Communications Biology A SC push-pull interaction during the dynamic vision mode, revealed with functional MRI and brain lesions, challenges the notion that intertectal connections solely serve as reciprocal inhibitory mech...

🧠👁️A SC push-pull interaction during the dynamic vision mode, revealed with fMRI and brain lesions, challenges the notion that intertectal connections solely serve as reciprocal inhibitory mechanisms for avoiding visual blur during saccades. @shemesh-lab.bsky.social

doi.org/10.1038/s420...

Evidence for a push-pull interaction between superior colliculi in monocular dynamic vision mode - Communications Biology A SC push-pull interaction during the dynamic vision mode, revealed with functional MRI and brain lesions, challenges the notion that intertectal connections solely serve as reciprocal inhibitory mech...

new paper from the Lab, harnessing fMRI and lesions to reveal some interesting "push-pull" interactions in Superior Colliculus! Check it out here
www.nature.com/articles/s42...

Congrats Mafalda!

Neuroplasticity-driven timing modulations revealed by ultrafast functional magnetic resonance imaging Detecting neuroplasticity in global brain circuits in vivo is key for understanding myriad processes such as memory, learning, and recovery from injur…

Nice work. Note also these:

www.nature.com/articles/s41...

www.sciencedirect.com/science/arti...

1/ Six years in the making! Our preprint on SORDINO fMRI is out. We're sharing the raw data and sequence to facilitate brain-wide mapping in awake, behaving rodents. If this could be useful to your colleagues and friends, please help spread the word!
www.biorxiv.org/content/10.1...