Sophie Chauvet

Pancreatic Cancer Symptoms: Cancer alert: Oral microbes identified as new risk factor for pancreatic cancer (early signs, other risk factors, and prevention tips) | - United States A groundbreaking study reveals a surprising link between oral microbes and pancreatic cancer risk. Researchers found certain bacteria and fungi, inclu

Pancreatic Cancer Symptoms: Cancer alert: Oral microbes identified as new risk factor for pancreatic cancer (early signs, other risk factors, and prevention tips) |

https://www.europesays.com/us/277980/

Known as a “silent killer,” pancreatic cancer mostly creeps in quietly with …#us #news #usnews

🧪 Nice day yesterday in Luminy, Marseille 🇫🇷 at the occasion of the Symposium "Linking neural development, human disease and evolution"!
🧠Great talks from @sophiechauvet.bsky.social Francois Féron, @angofab.bsky.social, Vincent Cantagrel, @fekrijeselimi.bsky.social @franckp.bsky.social.

Vous souhaitez contribuer à la mise en place de module de formation en ligne pour la formation applicateurs rongeurs ?

Rejoignez AMU pour concevoir des parcours numériques innovants.

📍 Poste basé à Aix-Marseille Université

recrutement.univ-amu.fr/fr/offres/ex...

Advances in Pancreatic Neuroendocrine Tumor (PNET) Treatments Dr. Diane Reidy-Lagunes outlines the current state of treatments for pancreatic neuroendocrine tumors (PNETs).

Dr. Diane Reidy-Lagunes outlines the current state of treatments for pancreatic neuroendocrine tumors (PNETs). https://bit.ly/44YCJGv

Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches Chen et al. identify two distinct antigen-presenting cancer-associated fibroblast (apCAF) populations across multiple cancer types. Mesothelial-related apCAFs locate near cancer cells while fibrocyte-...

Our paper online now, CAF molecular phenotypes are more conserved than we thought across organs. Plus we now know more details about apCAFs. Please check it out 👉 Cancer Cell www.cell.com/cancer-cell/...

Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses @cp-cancercell.bsky.social
www.cell.com/cancer-cell/...

www.linkedin.com/jobs/view/43...

Unraveling the glyco-immunity nexus in pancreatic cancer - Molecular Cancer Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease, and standard of care therapies have failed to yield significant clinical benefit, with invasive surgery being the only curat...

Unraveling the glyco-immunity nexus in #PancreaticCancer molecular-cancer.biomedcentral.com/articles/10.... 🧪

Is your AI benchmark lying to you? Artificial intelligence models are too often assessed against flawed goals — a stumbling block for progress.

Artificial intelligence models are too often assessed against flawed goals — a stumbling block for progress

go.nature.com/3Jmifin

Lipid metabolism and neuroinflammation: What is the link? rupress.org/jem/article/...

EBV induces CNS homing of B cells attracting inflammatory T cells - Nature Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.

How does Epstein- Barr virus induce multiple sclerosis?
The infection leads to B cells that get into the brain, attracting pro-inflammatory T cells (mouse model)
www.nature.com/articles/s41...

Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers Overcoming resistance to KRAS∗-targeted therapy remains a major challenge. Theardy et al. demonstrate that YAP1 drives the recovery of surface SDC1 upon KRAS∗ inhibition by downregulating ARF6 GAPs, thereby activating RTKs and macropinocytosis to promote resistance. Targeting the YAP1-SDC1 axis represents a promising strategy to combat resistance in KRAS∗-driven cancers.

Online now: Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers

High levels of circular DNA made as immune cells develop increases the risk of leukaemia relapse DNA segments that are naturally excised during immune-cell development can replicate, drive damage at various genomic sites and lead to cancer recurrence.

DNA segments that are naturally excised during immune-cell development can replicate, drive damage at various genomic sites and lead to cancer recurrence

go.nature.com/45KA3eX

Stressomic: A wearable microfluidic biosensor for dynamic profiling of multiple stress hormones in sweat A wearable sensor enables dynamic and noninvasive monitoring of multiple stress hormones to personalize stress management.

A wearable sensor that measures multiple hormones simultaneously in sweat to provide continuous real-time metrics and dynamics of stress
www.science.org/doi/10.1126/...

What You Need To Know About Screening for Pancreatic Cancer | PancChat Podcast with Alisyn Camerota | Episode 4 Who should be screened for pancreatic cancer, and when should it start? In this episode of PancChat, host Alisyn Camerota speaks with leading experts Dr. Michael Goggins (Johns Hopkins) and Dr. Anirban Maitra (MD Anderson / NYU Langone) about identifying higher-risk individuals and creating...

🎧 New #PancChat episode: "What You Need To Know About Screening for Pancreatic Cancer" @AlisynCamerota talks with Dr. Anirban Maitra & Dr. Michael Goggins about who should get screened, when to start, and the future of early detection including AI advances.

Credible inferences in microbiome research: ensuring rigour, reproducibility and relevance in the era of AI Nature Reviews Gastroenterology & Hepatology, Published online: 31 July 2025; doi:10.1038/s41575-025-01100-9Artificial intelligence (AI) is a powerful tool that could be applied to microbiome research. This Perspective discusses best practices and current limitations with the application of AI in microbiome data research, giving insights into future use and practical advice and recommendations on its use.

ICYMI: New online! Credible inferences in microbiome research: ensuring rigour, reproducibility and relevance in the era of AI

Good schematic on the lithium discovery www.nature.com/articles/d41...

Single-cell multitargets and mRNA sequencing enable the simultaneous profiling of transcriptome and up to six histone modifications in individual cells
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

🧠 Opportunity for a post-doctoral position on human neurobiology, funded by the @erc.europa.eu!
🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you!
🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...

🌴😎🌊 🩴 | Aix Marseille Université vous souhaite un bel été !

Nous marquons une pause en cette fin d'année universitaire
On se retrouve à la rentrée avec plein de nouveautés !

Passez de bonnes vacances🙏

Precisely defining disease variant effects in CRISPR-edited single cells - Nature A plate-based assay called CRAFTseq has been developed that uses ‘multi-omic’ single-cell RNA sequencing and direct genotyping of CRISPR edits to test the functional effects of genetic variants on cell state and function.

Nature research paper: Precisely defining disease variant effects in CRISPR-edited single cells

go.nature.com/44M3ygX

Association between ultra-processed food consumption and lung cancer risk: a population-based cohort study Background The evidence on associations between ultra-processed foods (UPF) and lung cancer risk is limited and inconsistent. Research question Are UPF associated with an increased risk of lung cance...

Ultraprocessed food intake and increased risk of lung cancer thorax.bmj.com/content/earl...

Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer Chen et al. integrate sc/snRNA-seq with spatial transcriptomics to characterize cellular composition, lineage dynamics, and spatial architecture in PDAC tissues with varying neural invasion status, un...

Pancreatic cancer cells can hijack neurons to facility their growth and spread. Here's the single-cell map (spatial mics) of the process
www.cell.com/cancer-cell/...

Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social
jci.org/articles/vie... 1/6

Targeting tumor-associated CCR2+ macrophages to inhibit pancreatic cancer recurrence following irreversible electroporation Inhibition of a distinct macrophage subcluster is expected to hinder recurrence of pancreatic cancer after IRE ablation.

Targeting tumor-associated CCR2+ macrophages to inhibit pancreatic cancer recurrence following irreversible electroporation
Science Advances
www.science.org/doi/10.1126/...

Stanford cancer scientists awarded funding for cancer AI A team of Stanford cancer scientists has been awarded to develop AI models that integrate different data types and identify biomarkers to predict whether a patient will respond to a specific cancer…

A team of Stanford cancer scientists has been awarded to develop #AI models that integrate different data types and identify biomarkers to predict whether a patient will respond to a specific #CancerTreatment. med.stanford.edu/cancer/about...

A gut microbiome metabolite promotes atherosclerosis by hijacking the immune system
@nature.com
nature.com/articles/s41...
www.nature.com/articles/d41...

The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets Knol et al. report a large pan-cancer proteome landscape based on high-throughput, single-shot mass spectrometry across 22 cancer types including both liquid (n = 4) and solid cancers (n = 18), revealing co-expression-based phenotypes and immune phenotypes and defining top 25 ranked proteins as potential biomarkers and drug targets for each cancer type as well as a multi-cancer classifier.

The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets

🔬 The next international Developmental Biology course, organized by Institut Curie with @sorbonne-universite.fr, will focus on "From stem #cells to #morphogenesis".

📅 Apply by:
• July 20 (3.5 weeks with hands-on workshop)
• Aug 31 (10 days of seminars)

🔗 training.institut-curie.org/courses/deve...