Hormone therapy is back after decades in the shadows. But evidence gaps remain for treating perimenopause — often the most disruptive part of the menopause transition.
go.nature.com/4b4kvqh
Forever chemicals (PFAS), implicated for many adverse health outcomes, don't have to be forever. They can even be broken down to do something good!
nature.com/articles/d41...
@nature.com
Predicting the risk of developing Alzheimer's disease in the next 10 years with blood biomarkers, such as p-Tau217
www.nature.com/articles/s41... @naturemedicine.bsky.social
A full aurora ring over a bay in Iceland
#bluesky #photography #nature #art #landscape #light #travel
Nature research paper: MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC
https://go.nature.com/41IPJwX
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If you were taught to test for proportional hazards, talk to your teacher.
The proportional hazards assumption is implausible in most #randomized and #observational studies because the hazard ratios aren't expected to be constant during the follow-up. So "testing" is futile.
But there is more 👇
Figure 3. Effects of Treatment on Risk for Major Adverse Cardiovascular Events
In people with type 2 #diabetes, sodium-glucose cotransporter 2 (SGLT2) inhibitors and GLP-1 receptor agonists were associated with lower risk of major adverse cardiovascular events.
ja.ma/4jE7Axf
#MedSky
This is figure 1, which shows ingroup solidarity and outgroup hostility of LLMs and human datasets.
Research in Nature Computational Science shows that large language models exhibit social identity biases similar to humans, having favoritism toward ingroups and hostility toward outgroups. https://go.nature.com/4gjBtku 🧪
An array of fruits and vegetables. Stock image.
A study in Scientific Reports finds that both high fruit and high vegetable intake were associated with lower depressive symptoms in people over 45 years old. Only moderate vegetable intakes were associated with lower depressive symptoms. https://go.nature.com/3ZDOIGL 🧪
Using causal diagrams within the Grading of Recommendations, Assessment, Development and Evaluation framework to evaluate confounding adjustment in observational studies - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
If you're working with Nightingale Health metabolomics data from UK Biobank, be sure to check out the excellent (and important) work @sritchie73.bsky.social and colleagues have done on its QC and normalisation: www.nature.com/articles/s41...
ukbnmr on CRAN: cran.r-project.org/web/packages...
JAMA Visual Abstract
Most viewed in the last 7 days from JAMA: Muvalaplin reduced lipoprotein(a) measured using intact lipoprotein(a) and apolipoprotein(a)-based assays and was well tolerated.
https://ja.ma/3CP8Ix0
World map displaying the number of people with (A) diabetes and (B) untreated diabetes in 2022. Copyright: 2024 The Author(s). Published by Elsevier Ltd. CC BY 4.0.
Over 800 million adults are now living with #diabetes worldwide with more than half not receiving treatment, global analysis suggests.
Explore the findings ▶️ bit.ly/3Be89wl
#KeyConceptSeries: A brief note on the random-effects meta-analysis model and its relationship to other models - @jclinepi.bsky.social
www.jclinepi.com/article/S089...
This is figure 1, which shows the consistent global links between coffee consumption and the human gut microbiome.
Coffee consumption is associated with the presence and abundance of a specific member of the human gut microbiome, Lawsonibacter asaccharolyticus, and changes to the plasma metabolome, according to a paper in Nature Microbiology. https://go.nature.com/3CIl4as 🧪
