Jaeda Coutinho-Budd

Unreal, the impact this is having on scientists. I spent over 700 hrs writing 4 grants submitted Apr-Sept that *might* have been funded next Apr; 2 abt to be 3 apps missed review bc of shutdown. In normal times takes 9-24 mo to get a grant funded. No hope for labs like mine. Literally no hope.

While the government was shut down, 379 NIH study section meetings (containing 24,380 grant applications) were postponed. NIH is committed to getting these reviewed, but please be patient and understanding with staff, as this is a complex and heavy lift.

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity - Molecular Neurodegeneration To define how Aβ pathology alters microglia function in Alzheimer’s disease, we profiled the microglia surfaceome following treatment with Aβ fibrils. Our findings reveal that Aβ-associated human micr...

Our new paper is out! Amyloid plaques switch on microglial GPC4, increasing neuronal tau uptake & toxicity—defining an amyloid→glia→tau pathway & a potential drug target. Pleasure to work with our collaborator @jcoutinhobudd.bsky.social. doi.org/10.1186/s130...

#Alzheimers #Glia #Tau #Amyloid

🚨 We’re hiring! 🧪 @uvabio.bsky.social
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity - Molecular Neurodegeneration To define how Aβ pathology alters microglia function in Alzheimer’s disease, we profiled the microglia surfaceome following treatment with Aβ fibrils. Our findings reveal that Aβ-associated human micr...

β-Amyloid induces #microglial expression of GPC4 and #APOE leading to increased neuronal tau pathology and toxicity

Brandon B. Holmes, Thaddeus K. Weigel, Jesseca M. Chung...James A. Wells #AlzheimersDisease #drosophila #amyloid #microglia @ucsanfrancisco.bsky.social

bit.ly/3HXP98J

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity - Molecular Neurodegeneration To define how Aβ pathology alters microglia function in Alzheimer’s disease, we profiled the microglia surfaceome following treatment with Aβ fibrils. Our findings reveal that Aβ-associated human micr...

It was fantastic to work with Dr. Holmes and colleagues to integrate work from flies to humans in Alzheimer’s

molecularneurodegeneration.biomedcentral.com/articles/10....

Dear Fly Community, In May 2025, the NIH terminated all grant funding to Harvard University, including the NHGRI grant that supported FlyBase. This grant also funded FlyBase teams at Indiana University (IU) and the University of Cambridge (UK), and as a result, their subawards were also canceled. The Cambridge team has secured support for one to two years through generous donations from the European fly community, emergency funding from the Wellcome Trust, and support from the University of Cambridge. At IU, funding has been secured for one year thanks to reserve funds from Thom Kaufman and a supplement from ORIP/NIH to the Bloomington Drosophila Stock Center (BDSC). Unfortunately, the situation at Harvard is far more critical. Harvard University had supported FlyBase staff since May but recently denied a request for extended bridge funding. As a result, all eight employees (four full-time and four part-time) were abruptly laid off, with termination dates ranging from August to mid-October depending on their positions. In addition, our curator at the University of New Mexico will leave her position at the end of August. This decision came as a shock, and we are urgently pursuing all possible funding options. To put the need into perspective: although FlyBase is free to use, it is not free to make. It takes large teams of people and millions of dollars a year to create FlyBase to support fly research (the last NHGRI grant supported us with more than 2 million USD per annum). To help sustain FlyBase operations, we have been reaching out to you to ask for your support. We have set up a donation site in Cambridge, UK, to which European labs have and can continue to contribute, and a new donation site at IU to which labs in the US and the rest of the world can contribute. We urge researchers to work with their grant administrators to contribute to FlyBase via these sites if at all possible, as more of the money will go to FlyBase. However, we appreciate that some fu…

https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase Our immediate goals are: 1. To maintain core curation activities and keep the FlyBase website online 2. To complete integration with the Alliance of Genome Resources (The Alliance). Integration with the Alliance is essential for FlyBase’s long-term sustainability. For nearly a decade, NHGRI/NIH has supported the unification of Model Organism Databases (MODs) into the Alliance, which we aim to achieve by 2028. Therefore, securing bridge funding to sustain FlyBase over the next three years is crucial for successful integration and the long-term access to FlyBase data. At present, our remaining funds will allow us to keep the FlyBase website online for approximately one more year. Beyond that, its future is uncertain unless new funding is secured. We will, of course, continue pursuing additional grant opportunities as they arise. Given the uncertainty of future NIH or alternative funding sources, we are relying on the Fly community for support. Your contributions will directly help us retain the staff needed to complete this transition and to secure ongoing fly data curation into the Alliance beyond 2028. We at FlyBase are incredibly grateful for the outpouring of support from the community during this challenging time. Your encouragement has strengthened our resolve and underscores how vital this resource remains to Drosophila research worldwide. Sincerely, The FlyBase Team

The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share

Fly folk:

The Amazing and essential @flybase.bsky.social is in existential need due to Trump termination of the grant that supports this vital resource.

Please donate to help keep Flybase alive. I just did. Info here on how to make a tax deductible donation:

wiki.flybase.org/wiki/FlyBase...

So excited this is finally out! 🎉

doi.org/10.1002/glia...

Fear and loathing on study section: Reviewing grant proposals while the system is burning As grants are canceled, delayed and subject to general uncertainty, participating in study sections can feel futile. But it’s more important than ever.

i wrote an essay for @thetransmitter.bsky.social about what it feels like to serve on an NIH grant review panel (study section) right now

www.thetransmitter.org/craft-and-ca...

If your representatives are not REPRESENTING YOU and making life harder for you, you need to fire them. That's it.

Tardigrade-obsessed: meet the researchers trying to turn water bears into neuroscience models For water-bear enthusiasts, it’s the creature’s legs that make it stand out.

WOW, WE'RE DOING TARDIGRADE NEUROSCIENCE? Noice!
www.nature.com/articles/d41...

The man behind me in the grocery line just told the cashier to continue ringing through to his stuff and he was gonna pay for mine. It was literally $200. He said that he’s been going through some stuff lately and he just wants to do something good. 🥹

Reminder: there is still good in this world. ❤️🙏

“Campus leaders need to understand that their capitulations and concessions only further empower the greatest threat to higher education since the Red Scare, if not earlier.”

(The AAUP contends that this moment is far worse.)

Act Now.

Never Cave.

#DefendHigherEd

Call for 20 Assistant Professor positions Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.

ki.se/en/about-ki/...

University of Virginia President Resigns Under Pressure From Trump Administration

Wow. Just wow.

University of Virginia President Resigns Under Pressure From Trump Administration www.nytimes.com/2025/06/27/u...

URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯

Any lab using @flybase.bsky.social please donate using the link in post below.

This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.

Happy to present a single cell atlas of ALL glia, in BOTH sexes of an animal (in vivo validated!)! Fab work by postdoc @glia-maria.bsky.social, team, & collaboration with @manusetty.bsky.social . Find insights into glia, new analytics and ML models, and browse our companion website (wormglia.org)

Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! 👉 nyumc.qualtrics.com/jfe/form/SV_...
#Neuroscience #Postdoc #ResearchOpportunity

"We are speaking on behalf of hundreds of NIH staff who are standing up together to say: WE DISSENT.

I am so scared about doing this but I am trying to be brave for my kids because it's only gonna get harder to speak up."

Thank you to Dr. Jenna Norton and NIH scientists for your courage!

the word alert is in a purple circle ALT: the word alert is in a purple circle

ACTION ITEM-----ACTION ITEM

Implementation of Schedule F

This is what a lot of us have been worried about.

This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.

BUT THERE IS A COMMENT PERIOD...

1/n

Lab Tech/Specialist Varying Levels - Neuroscience in Charlottesville, Virginia, United States of America | Research at University of Virginia Apply for Lab Tech/Specialist Varying Levels - Neuroscience job with University of Virginia in Charlottesville, Virginia, United States of America. Research at University of Virginia

Know anyone looking for a lab specialist/technician job? The Ross lab is hiring! This position will help the lab with our research on anti-tumor immunity in high-grade glioma. Incredible training environment!!
🐭🔬🧪🦠🧠

jobs.virginia.edu/us/en/job/R0...

After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology.

Science on our sleeves: the research that inspires our tattoos Inked scientists choose scientific images to mark career accomplishments and illustrate their research passion.

Nature has a story on science tattoos, in which they quoted me about my 2011 book, Science Ink (still in print!) www.nature.com/articles/d41...

a man in a suit and tie with nbc written on the bottom right ALT: a man in a suit and tie with nbc written on the bottom right

I wonder, for those of us on a tenure clock, how will this situation factor in?

We’re not playing the same game we set out to play.

Bad news for all of us: champion for inclusion & excellence @ NIH/NINDS Dr. Michelle Jones-London is leaving NINDS.💔
She helped launch the career of countless cutting-edge neuroscientists & set the standard for training. Great news of course for where ever she goes next. 🧪🧠@jeremymberg.bsky.social

NIH PostBac program is open again! And I will be hiring! #JobPostComing

www.training.nih.gov/research-tra...

The Coming Out of a Transgender Scientist "I know that I am making the right decision because whenever I think about changing my gender role, I am flooded with feelings of relief."

We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.

a red warning light is lit up in front of a building ALT: a red warning light is lit up in front of a building

The horror show continues at NIH

I am hearing (reliably) that RIFs have started with entire institute Communication branches being terminated since their jobs not longer exist (reduction in force).

But that is not all...

STILL no New or Competing Renewal awards from NIGMS. Only NIGMS seems to not be making these awards.