Jiri Hofbrucker

Very interesting paper!

Glia in Focus 🔬
A series highlighting the beauty of glial cells. Confocal image (64x) of rodent brain tissue (P1) showing microglia (Iba1, magenta) near a CMV-infected microglial cell (green).
Image: @Sarah Tarhini

#GliaInFocus #Microglia #ConfocalMicroscopy #BrainDevelopment #ScienceArt

Amazing. Congratulations Sanja!

As Neurophotonics developers, we love learning about in vivo imaging directly from scientists.
We’re recruiting 20participants for our in vivo imaging survey.
⏱️ ~10 min
🎁 Free neuron socks
Work with in vivo animal imaging? Contact us at info@deepen-imaging.com.
#neuroscience #microscopy#neuroimaging

As Neurophotonics developers, we love learning about in vivo imaging directly from scientists.
We’re recruiting 20participants for our in vivo imaging survey.
⏱️ ~10 min
🎁 Free neuron socks
Work with in vivo animal imaging? Contact us at info@deepen-imaging.com.
#neuroscience #microscopy#neuroimaging

🚀 Excited to announce that I'm looking for people (PhD/Postdoc) to join my Cognitive Modelling group @uniosnabrueck.bsky.social.

If you want to join a genuinely curious, welcoming and inclusive community of Coxis, apply here:
tinyurl.com/coxijobs

Please RT - deadline is Jan 4‼️

#SfN25 is now over!
Thanks to all the lovely people who came to our booth and shared their science stories with us!
It was an inspirational week for DeepEn!
Thanks to @sfn.org for an extraordinary meeting!

🧠📢 New preprint alert

Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵

#neuroskyence #compneurosky

DeepEn is at NEUROSCIENCE 2025 #SfN25 ! 🧠🔬🌴
Come to our BOOTH #3027, check our microendoscope for deep brain imaging with sub cellular resolution and minimal tissue damage.
And meet Hana, Tomas, Patrick and Jiri!

#neuroimaging

I'm excited to join #SfN2025 next week. Stop by booth #3027 to connect and learn more about structural and functional imaging in-vivo anywhere in the brain! I’d love to hear about your research and ideas! Looking forward to meeting you there.

Image from the MIT Picower article, "MIT invents human brain model with six major cell types to enable personalized disease research, drug discovery" with the following caption: “Cyan staining shows each of the six major cell types [pericytes, astrocytes, endothelial cells, neurons, oligodendrocytes, and microglia] integrated in a miBrain culture.” The original image appeared in Figure 1 of the PNAS article, “Engineered 3D immuno-glial-neurovascular human miBrain model” (10.1073/pnas.2511596122) by Stanton et al.

This new miBrain model from MIT has it all:

🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
⚙️ Key features & functions of the human brain
👩‍👦 Specificity to individual donors
🧬 Customizability via gene editing
📈 Scalability for large projects

High-resolution insights from the deep brain Discover the world’s best science and medicine | Nature.com

🧠What do neuroscientists think of DeepEn's holographic microendoscope?
How can they use it to study learning and memory processes?
Can it enable voltage imaging in deep brain structures to study processes behind neuronal firing?

⭐ Check the Nature’s article:
www.nature.com/articles/d42...

Excited to share we’ve been awarded the ERC StG 🎉 for our project ProSocial, studying neural mechanisms of prosocial behavior in health & disease. Huge thanks to my group for their amazing work & to great colleagues for their support! Positions opening soon—reach out if interested!

Are you the kind of neuroscientist who scripts analysis or can’t resist tinkering with hardware?
At DeepEn we’re building a fluorescence microscope to image deep in the brain through a single optical fiber. Join us to hack the future of neuroimaging: #ScienceJob
www.linkedin.com/jobs/view/42...

5th Day of Intravital Microscopy - German BioImaging Intravital microscopy (IVM) enables the observation and precise quantification of cellular processes within native tissue microenvironments, with resolutions unmatched by other techniques. This powerf...

⏰ Reminder: The early bird registration and abstract submission for our 5th Day of Intravital Microscopy close on September 5!
Don’t miss your chance to join us in Tübingen on 18–19 Sept. Secure your spot today!
👉 bit.ly/3IOlJtJ

Beautiful work!

Fun collaborative work together with the amazing lab of @sophiesteculorum.bsky.social now published!

A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution - Nature A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promise...

www.nature.com/articles/s41...

A fantastic overview of where three-photon microscopy stands relative to existing methods. It's clear that while the technology is still maturing, its advantages for deep-brain imaging!

Hippocampal vasculature is so pretty 😍
(mouse hippocampus perfused with Tomato Lectin and cleared)
#Neuroscience #Microscopy

Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo Papanikolaou et al. show that deep-layer cortical neurons exhibit abnormally prolonged Ca2+ transients early in Alzheimer’s mouse models. This is linked to suppressed activity and altered tuning of fa...

Where does Alzheimer’s begin in the brain? Our study in @cp-neuron.bsky.social shows that the earliest amyloid-related neuronal dysfunction emerges selectively in deep cortical layers (layers 5/6), targeting fast-spiking parvalbumin interneurons via reductions in NPTX2.
www.cell.com/neuron/fullt...

Please welcome our official #mesoSPIM channel on this platform, @mesospim.bsky.social. Repost is appreciated!

Too excited not to share this beauty!
#fluorescenceFriday (but a day earlier)

TH staining in cyan
Virus injection in magenta

Zona Incerta is definitely a tough cookie 🍪 but getting there!

Beautiful axons indeed! A quick technical question. What technique did you use to target the amygdala during ferrule implantation?

A picture of a gigaseal during electrophysiological recording in neuron.

🧠 GABA! 🔬✨Explore groundbreaking research on the GABAergic system and its role in health and disease in humans and rodents.
Learn more by joining us #NeuronsInAction2025!
📍the Nencki Institute, Warsaw, Poland
📅 27-31 May, 2025
#nia2025 #neuronsinaction2025 #neuroscience #brain #nenckiinstitute

Excellent Norbert Elsner Lecture by Rui Costa @ruimcosta.bsky.social, Göttingen Meeting of @neurowissg.bsky.social

📣 1 week to go!

Get ready for a LIVE DEMO of our Holographic Microendoscope for high resolution deep brain imaging 🧠 🔬

📍at the 16th Göttingen Meeting of the German Neuroscience Society

Come to our booth and tell us about your research ideas!
#NWG2025
#GöttingenMeeting
#Neuroscience

In vivo image captured of a neuron labeled with a calcium indicator

Just so happened to see this beauty today while recording in Kash Lab @superkash.bsky.social. Happy #FluorescenceFriday 🤩🔬

Happy #BrainAwarenessWeek! Join this international celebration of the brain with this visual exploration of its makeup and neighborhoods: alleninstitute.org/news/what-ar...

🧠📈 @danafoundation.bsky.social

Do you want to join a great team and work on cutting-edge confocal microscopy systems?

Join us at Confocal NL as a Product Application Specialist and help researchers globally accelerate their discoveries with our disruptive technology!

Apply here: confocal.recruitee.com/o/product-ap...