Natalie hauglund

@ritikamukherji.bsky.social @vyazovskiy.bsky.social

Preprint alert: If sleep is the cousin of death, torpor must be its fraternal twin. Yet, daily torpor is surprisingly dynamic when zooming in on the slow fluctuations in motility, brain activity, and temperature. Read (and see👀) more on bioRxiv! www.biorxiv.org/content/10.6...

Rest and rinse: sleeping rhythms drive brain detox Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Re...

Our News and Views on @nataliehauglund.bsky.social and Maiken Nedergaard's recent study showing how sleep drives brain waste clearance @cp-trendsimmuno.bsky.social

www.cell.com/trends/immun...

Love the figures!! Great work 😄

Fantastic 'Banana' Voyage! 🚀🍌 I'm practicing @napari.fosstodon.org.ap.brid.gy for my 'real' future scientific presentation. It's truly a fruitful software, and I'm excited to explore more of what I can do with it! :)

In conclusion, neuronal activity surrounding micro-arousals is complex and under strong homeostatic regulation. We still have a lot to learn about this mysterious feature of sleep!
Thanks to @vyazovskiy.bsky.social lab and co-authors for letting me play around with the amazing data 📊

5) Short (duration below 3 seconds) arousals tend to be associated with an overall decrease in firing rate, but not longer lasting arousals

4) Analysis of single channels within the cortical layers showed that some channels exhibit increased firing rates right before the micro-arousal while other channels have decreased firing during the micro-arousal

3) NREM sleep micro-arousals have different neuronal activity profiles than micro-arousals following REM sleep

2) slow wave activity (SWA) in a ~10s period immediately after micro-arousals is highly sensitive to sleep/wake history to an extent where post-arousal SWA is higher than NREM sleep SWA in sleep deprived mice

1) micro-arousals are associated with a decrease in power throughout the layers of the motor cortex

New preprint now online! www.biorxiv.org/content/10.1...

We created an algorithm to detect NREM sleep micro-arousals and used it to re-analyze LFP data from the motor cortex of sleeping mice 💤 This is what we found:

Thalamic involvement defines distinct slow-wave subtypes in NREM sleep Slow waves (0.5-4 Hz) are a key feature of non-rapid-eye-movement (NREM) sleep, traditionally believed to arise from neocortical circuits. However, growing evidence suggests that subcortical structure...

New preprint from our lab, in collaboration with Jeff Duyn's group at NIH!! 🚨Bergamo et al., "Thalamic involvement defines distinct slow-wave subtypes in NREM sleep." Link: www.biorxiv.org/content/10.1...

Awesome paper, really enjoyed reading it! Would be interesting to know if those C1 waves coincide with noradrenaline release 🤔

Great write about our study in @nature.com 🧠

If any of you have questions or comments or want do discuss the findings, please write! 😀 Let's have a journal club 😎

Furthermore, we find that the sleep aid Zolpidem (Ambien) disrupt the pumping system and impairs brain cleaning 🧠🚿

Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep Norepinephrine oscillations during NREM sleep drive synchronized changes in cerebral blood volume and cerebrospinal fluid, promoting glymphatic clearance. Optogenetic and pharmacological manipulations confirm that vasomotion, regulated by norepinephrine, acts as a pump for brain fluid transport.

Out in @cellcellpress.bsky.social !
We show that oscillations in norepinephrine and cerebral blood volume are the missing pieces that link NREM sleep to clearance of waste from the brain 🧠💤 www.cell.com/cell/fulltex...