Yi "Joey" Zhou

Important work in @nature.com from @gordfishell.bsky.social lab reveals pyramidal neurons can actively shape both the diversity and circuit integration of interneurons in the cortex.

Dissecting gene regulatory networks governing human cortical cell fate - Nature Systematic screening of transcription factors reveals conserved mechanisms governing cortical radial glia lineage progression across primates and provides a framework for functional dissecti...

Fascinating work in @nature.com from Alex Pollen lab using CRISPRi screening to identify key transcription factors driving human radial glial neural stem cell fate—with causal validation. www.nature.com/articles/s41...

Cell-extrinsic controls over neocortical neuron fate and diversity Cell-extrinsic cues are key for neocortical cell identity and diversity.

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Position-independent emergence of neocortical neuron molecular identity, connectivity and function - Nature Neuroscience Even when neocortical neurons form in abnormal locations, they retain their identity and function, revealing that brain circuit formation can be guided by intrinsic developmental programs rather than ...

I'm very excited to finally see this one out in @natneuro.nature.com ! It has been an incredible journey alongside extremely talented people! Thanks to everyone involved and enjoy the reading! 1/n
www.nature.com/articles/s41...

Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates Specialized cell types and links to psychiatric disorders are revealed by genetic mapping of primate amygdala neurons.

Very excited to share my second postdoc, now out in Science Advances! We used targeted snRNA-seq to profile four major subnuclei of the primate across three species (including humans). 1/13 www.science.org/doi/10.1126/...

Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...

Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes

@zhoujoeyyi.bsky.social

www.nature.com/articles/s41...

Thank you for the insightful feedback during our last meeting—truly appreciated!

Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes Nature Neuroscience - Machine-learning-augmented single-nucleus transcriptomic analysis compared molecular landscapes of immature neurons in the mammalian hippocampus across species, highlighting...

Full text available at rdcu.be/eAcNN

Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes - Nature Neuroscience Machine-learning-augmented single-nucleus transcriptomic analysis compared molecular landscapes of immature neurons in the mammalian hippocampus across species, highlighting human-specific gene expres...

Excited to share our study published in @natneuro.nature.com today! We conducted cross-species analyses of immature neurons arising from adult hippocampal neurogenesis, revealing distinct human-specific gene expression patterns but convergent biological processes. www.nature.com/articles/s41...

Congratulations Xuyu!

Great work in @nature.com by @qianxuyu.bsky.social from Dr. Chris Walsh lab revealing early specification of the human cortex using spatial omics. Congratulations Xuyu!🎊🎉

A new study in preprint from @amarsahay.bsky.social lab shows that prolonged maturation of adult-born hippocampal neurons affects hippocampal network by strengthening inhibitory brain circuitry. doi.org/10.21203/rs....

Thank you Giorgia!!

New preprint out from the lab, check out thread below!

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Thank you, Dr. Boeckx, for highlighting our work ! It’s exciting to see the convergence of our findings, which suggest that lysosome function in neuronal development evolves across species in a spatiotemporal- and cell type-dependent manner, with human lysosomes playing unique roles.

Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humans Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species and specialized features...

Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in different mammalian species👨🐵🐷🐭, revealing specialized features in humans. www.biorxiv.org/content/10.1...