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Gui Villagomez

@guiviol

Craniofacial Development & Tissue Regeneration πŸ‡²πŸ‡½

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23.11.2024
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Latest posts by Gui Villagomez @guiviol

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We're excited to announce that registration for our upcoming Spatial Omics workshop has opened!

Details in 🧡

26.02.2026 17:39 πŸ‘ 3 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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A Visual Guide to DNA Sequencing.

Learn how different DNA sequencing technologies work, from Sanger sequencing to Illumina to nanopores. (Complete with illustrations!)

Written by Evan DeTurk. Illustrated by Ella Watkins-Dulaney.

26.02.2026 18:17 πŸ‘ 9 πŸ” 3 πŸ’¬ 1 πŸ“Œ 1
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🚨Next DevBioConnect on the way

Developmental Biology Author webinar featuring Dr. Diana L. Carlone & Dr. Emil Kriukov πŸ“·

πŸ—“οΈMar. 10th, 2026
⏰11 am–12 pm CST

docs.google.com/forms/d/e/1F...

@socdevbio.bsky.social

www.sdbonline.org/meeting?Reso...

23.02.2026 17:50 πŸ‘ 8 πŸ” 6 πŸ’¬ 0 πŸ“Œ 2
Development presents... 

Wednesday 25 February – 15:00 GMT/UTC
Chair: Polina Kameneva

JoaquΓ­n Navajas Acedo (University of Basel)
β€˜Spatiotemporal emergence of somatosensory neuron diversity’

Carlo Donato Caiaffa (Universidade de SΓ£o Paulo)
β€˜Decoding the role of HNRNPH2 in neural development using brain organoids and antisense oligonucleotides’

Clarisse Brunet (Institut Curie)
β€˜Decoding the gliogenic switch: how human brain organoids reveal the secrets of glial cell fate’

#DevPres @dev-journal.bsky.social
theNode.biologists.com/devpres

The Company of Biologists logo 
Development logo

QR code

Development presents... Wednesday 25 February – 15:00 GMT/UTC Chair: Polina Kameneva JoaquΓ­n Navajas Acedo (University of Basel) β€˜Spatiotemporal emergence of somatosensory neuron diversity’ Carlo Donato Caiaffa (Universidade de SΓ£o Paulo) β€˜Decoding the role of HNRNPH2 in neural development using brain organoids and antisense oligonucleotides’ Clarisse Brunet (Institut Curie) β€˜Decoding the gliogenic switch: how human brain organoids reveal the secrets of glial cell fate’ #DevPres @dev-journal.bsky.social theNode.biologists.com/devpres The Company of Biologists logo Development logo QR code

πŸ“’Register for our #DevPres webinar on neurodevelopment

The webinar, chaired by Polina Kameneva, features talks from JoaquΓ­n Navajas Acedo @mads100tist.bsky.social, Carlo Donato Caiaffa & Clarisse Brunet @clarissebrunet.bsky.social.

πŸ—“οΈ25 February, 15:00 GMT/UTC

us02web.zoom.us/webinar/regi...

16.02.2026 14:18 πŸ‘ 27 πŸ” 12 πŸ’¬ 0 πŸ“Œ 7
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The $100 whole human genome sequence finally reached!
www.sandiegouniontribune.com/2026/02/19/s...

20.02.2026 20:29 πŸ‘ 258 πŸ” 77 πŸ’¬ 12 πŸ“Œ 11
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Ancestry and somatic profile indicate acral melanoma origin and prognosis - Nature Analysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples...

We are very happy to see our study finally appear online @nature.com! This has been work of nearly 10 years in collaboration with the National Institute of Genome Medicine πŸ‡²πŸ‡½, the National Cancer Institute πŸ‡²πŸ‡½, the @sangerinstitute.bsky.social and others ⬇️

www.nature.com/articles/s41...

18.02.2026 17:52 πŸ‘ 88 πŸ” 41 πŸ’¬ 13 πŸ“Œ 3
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🧡 10 free bioinformatics tools you should know in 2026. These will save you time, money, and headaches.

18.02.2026 14:15 πŸ‘ 9 πŸ” 3 πŸ’¬ 2 πŸ“Œ 1
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anndataR: converting single-cell data, from R to python and back tomsing1.github.io/blog/posts/a... #Rstats

17.02.2026 21:01 πŸ‘ 8 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Demystifying Oral Epithelial Dysplasia: a histological guide

Enhanced interpretation of WHO 28 features

Normal oral mucosa variants

Core architectural & cytologic abnormalities

#Pathology 2024
www.pathologyjournal.rcpa.edu.au/article/S003...

10.02.2026 19:53 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Mosaic partial epidermal reprogramming remodels neighbors and niches to refine skin homeostasis and repair @natcomms.nature.com
www.nature.com/articles/s41...

31.01.2026 03:19 πŸ‘ 9 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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New paper out today, 'Global North-South science inequalities due to language and funding barriers'

We highlight how language and funding barriers can compound inequity and offer practical recommendations to bridge these gaps.

Read the Open Access paper here! πŸ‘‰ tinyurl.com/654ztk3w

29.01.2026 05:14 πŸ‘ 27 πŸ” 12 πŸ’¬ 1 πŸ“Œ 1
Neural crest contribution to craniofacial structures and phenotypic variation

Neural crest contribution to craniofacial structures and phenotypic variation

#DBfeature

Bones, brains, and biasβ€”neural crest cell contribution to craniofacial structure

Active Learning Assignments for craniofacial perception & normal phenotypic variation

by Jeffrey Carmichael, Diane Darland et al
www.sciencedirect.com/science/arti...

29.01.2026 10:05 πŸ‘ 10 πŸ” 7 πŸ’¬ 1 πŸ“Œ 0
Figure 2 The dimensions of cancer
CREDIT Hanahan - Cell.

Figure 2 The dimensions of cancer CREDIT Hanahan - Cell.

An update to the Hallmarks of Cancer framework for understanding (and researching) what causes human cancers. spkl.io/63321Aqwbc

Douglas Hanahan
@cp-cell.bsky.social

29.01.2026 17:00 πŸ‘ 21 πŸ” 10 πŸ’¬ 0 πŸ“Œ 10
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Review @natprot.nature.com @garybader.bsky.social
Tutorial: annotation of animal genomes
www.nature.com/articles/s41...

28.01.2026 21:07 πŸ‘ 4 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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EGFR signaling in the tissue around oral cancers increases nerve sensitivity and impairs opioid efficacy
www.science.org/doi/10.1126/...

28.01.2026 23:45 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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This review reflects on a journey I’ve been lucky to witness closely:
◼️ The transformation of single-cell proteomics from a fragile idea into a powerful discipline.

The technological progress towards deeper coverage and higher throughput is fast and exciting, but what excites me most is ...

1/n

28.01.2026 16:47 πŸ‘ 8 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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🚨Next DevBioConnect on the way‼️
Developmental Biology Author webinar

by Dr. Alexa Burger & Dr. Robert Huebner

πŸ—“οΈ Feb 10th, 2026
⏰ 11 am–12 pm CST

To Register
forms.gle/4J192L42y6sg...

@socdevbio.bsky.social
@aburger2009.bsky.social

23.01.2026 18:28 πŸ‘ 11 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0
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#SpatialTranscriptomics
Visium
+ scRNAseq

Oral Squamous Cell Carcinoma
vs paired Oral Leukoplakia vs normal tissues

Inhibin A+ monocyte enriched in premalignant OLK lesions

1⃣Mesenchymal CAF 2⃣APOE+NRG1+ MΟ† 3⃣TNFRSF4+ Treg ⬆️with tumor progression

#CellDiscov 2023
www.nature.com/articles/s41...

19.01.2026 20:17 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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A competition model of multilineage priming and cell-fate decisions In development, cells navigate highly complex gene-regulatory landscapes to make fate choices. Steinschaden et al. synthesize concepts of multilineage priming, microheterogeneity, and collective multi...

Our review β€œA competition model of multilineage priming and cell-fate decisions” is out: www.cell.com/cell-reports...

19.01.2026 23:05 πŸ‘ 29 πŸ” 10 πŸ’¬ 0 πŸ“Œ 0
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Peer Bork died yesterday πŸ’” which shocked me. In 2003 I did a short-term fellowship in Peer’s lab because I idolized him. I met Martin there & we wrote this paper together. Peer was great at bringing people together; a master collaborator with a rare ability to think up big ideas.

18.01.2026 00:52 πŸ‘ 43 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0
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Non-negative matrix factorization is a commonly used technique in genomics data analysis.

Read my tutorial on how you can use it for single-cell RNAseq data divingintogeneticsandgenomics.com/post/matrix...

15.01.2026 15:15 πŸ‘ 5 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Chinese cell atlas reveals surprising immune variation among peoples @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41...

09.01.2026 02:30 πŸ‘ 6 πŸ” 5 πŸ’¬ 0 πŸ“Œ 1
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Growth factors secreted by sensory nerves promote fracture healing @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

09.01.2026 03:02 πŸ‘ 6 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Cartoon of Pax9 expression (purple) during facial development in mouse (left) and zebrafish (right).
Text: Mammals. Pax9 is expressed In tooth-forming mesenchyme around the mouth. Required for tooth formation in mouse and human.
Fish. Pax9 is also expressed in oral mesenchyme in fishes. But many fish do not form oral teeth. Vestigial expression or divergent function?
Result: pax9 is required for formation of upper jaw bones and barbels in zebrafish, but dispensable for non-oral teeth.
Support ancestral function in building peri-oral structures from condensed mesenchyme rather than a specific requirement for teeth

Cartoon of Pax9 expression (purple) during facial development in mouse (left) and zebrafish (right). Text: Mammals. Pax9 is expressed In tooth-forming mesenchyme around the mouth. Required for tooth formation in mouse and human. Fish. Pax9 is also expressed in oral mesenchyme in fishes. But many fish do not form oral teeth. Vestigial expression or divergent function? Result: pax9 is required for formation of upper jaw bones and barbels in zebrafish, but dispensable for non-oral teeth. Support ancestral function in building peri-oral structures from condensed mesenchyme rather than a specific requirement for teeth

#DBfeature 🐠

Pax9 has a broader role in initiating development of mesenchymal structures around the mouth during zebrafish development

By Sandhya Paudel, Sarah McLeod, Stefani Gjorcheska, Lindsey Barske

tinyurl.com/yc3jfpux

07.01.2026 10:34 πŸ‘ 11 πŸ” 10 πŸ’¬ 0 πŸ“Œ 1
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Scikit-bio: a fundamental Python library for biological omic data analysis - Nature Methods Nature Methods - Scikit-bio: a fundamental Python library for biological omic data analysis

Nice one!

www.nature.com/articles/s41...

07.01.2026 16:53 πŸ‘ 6 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1
Portrait of Brenna Henn next to an open freezer of samples.

Portrait of Brenna Henn next to an open freezer of samples.

Here's my latest contribution to the @nytimes "Lost Science" series. Brenna Henn's sweeping study of African genetics has been frozen. Gift link: nyti.ms/3Ypmm1A

05.01.2026 17:32 πŸ‘ 224 πŸ” 77 πŸ’¬ 3 πŸ“Œ 11
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WaveOrder is a powerful new #microscopy tool from Biohub that helps researchers reconstruct messy microscope data into clean, quantitative maps. It’s grounded in physics & it’s already changing how we see biology.

πŸ“š Preprint https://bit.ly/4jgDJLB
πŸ”¬WaveOrder: https://czi.co/4pMwGgb

05.01.2026 15:06 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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My statement on President Trump’s actions in Venezuela.

03.01.2026 22:27 πŸ‘ 6267 πŸ” 2044 πŸ’¬ 323 πŸ“Œ 170

Modern biology research is biased towards investigating genes that are widely conserved and present in humans. What about genes that ARE widely conserved but NOT present in humans? Can genes missing from humans tell us something about what makes our biology different from that of other animals? 1/8

31.12.2025 19:29 πŸ‘ 86 πŸ” 28 πŸ’¬ 10 πŸ“Œ 1
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Systematic cell-type resolved transcriptomes of 8 tissues in 8 lab and wild-derived mouse strains capture global and local expression variation
www.cell.com/cell-genomic... @ucirvine.bsky.social

02.01.2026 01:22 πŸ‘ 6 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0