Limitations of de novo sequencing in resolving sequence ambiguity De novo peptide sequencing enables peptide identification from fragmentation spectra without relying on sequence databases. However, incomplete spectra create ambiguity, making unambiguous identificat...

Exciting news: Preprint on the limitations of current de novo peptide sequencing models on dealing with sequence ambiguity is now out! It focuses on how current models deal with sequence ambiguity, and when and where they go wrong.

Check it out here: www.biorxiv.org/content/10.1...