We're discussing 💉REACT- renal autologous cell treatments (rilprencel) in diabetic kidney disease.
Is regenerative medicine the future of nephrology❓
Come discuss 3/10/26 at 9pm
#NephJC #NephSky
Blog by @drsaivani.bsky.social and @nephromommy-akshu.bsky.social
www.nephjc.com/news/rilprencel-react
T0i
So, if we dip into our Sci-Fi bag (I’m still waiting on a tricorder), we would develop a way to harvest specific lineages of renal cells, grow them in cultures outside the body and reinject them to damaged kidneys…and that is the idea behind rilparencel. #NephJC
VA in Espanol para 3/10/26 discussion
Gracias @dramiliflores.bsky.social
#NephJC #NephSky
www.nephjc.com/news/2026/3/9/react-el-resumen-visual
Will renal autologous cell treatments (REACT) unlock the secret to kidney regenerative medicine? #NephJC #NephSky
Come discuss 3/10/26 at 9pm EST
Check out the VA by @roxnonna23.bsky.social
www.nephjc.com/news/2026/3/9/react-the-visual-abstract
Here are the past winners #NephSky #NephJC
Good luck to all the nominees 🍀
It's the #NephJC Kidney Awards 🏆
Your chance to vote for your favorite #FOAMed creators and show some love 🥰
Sign up for the newsletter to receive a ballot 🗳️
Winners to be announced at the #NephJC graduation 3/22/26 10 am EST.
nephjc.com/news/nephjckidneys2026-vote
World Kidney Day is coming, and we’ll celebrate the field’s momentum. This #NephJCshort is a reminder that some practices should stay relics. Extreme dietary restriction feels archaic when modern therapies can hit same renal pathways without the ritualized deprivation
www.nephjc.com/news/2026/2/...
figure of albuminuria reduction with finerenone
Finally, FINEONE shows Finerenone
reduces albuminuria in T1DM
www.nejm.org/doi/full/10....
@nejm.org #NephSKy
And next Sunday the beginning of #NephMadness!
Who's psyched?
#NephJC
This has been Marc Soco -- thank you all for joining us tonight! 🙏
We hope you found the discussion insightful, and we can’t wait to see you in the next #NephJC session
Massive thanks as well to our mentors for guiding and supporting this session Cristina Popa Sayali Thakare @drpallaviprasad.bsky.social Swapnil Hiremath 🍁🇨🇦 Brian Rifkin #NephJC
Thanks to the amazing team for all the effort behind today’s #NephJC session Jeyakumar Meyyappan Shellie Fravel, PharmD Clemens Weber Dr.Sridatta
If you want to support #NephJC and get some cool merch, check out
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Up next on #NephJC
An RTC of kidney autologous cell therapy in diabetics with CKD
pubmed.ncbi.nlm.nih....
T3o
KDIGO 2026 anemia takeaway:
🩸Fix iron first
🩸Don’t overshoot Hb
🩸Be cautious with ESAs
🩸Stay curious about HIFs
🩸Avoid transfusions
Basically: 👉 Don’t panic
Nephrology = eternal balance ⚖️
Will you change your practice based on these guidelines? #NephJC
T3n
KDIGO stresses global applicability:
Guidance must work across diverse healthcare systems...
from high-resource dialysis centers to resource-limited settings
Implementation matters as much as evidence #NephJC
T3m
Guideline explicitly calls for more research on:
• Iron strategies
• ESA/HIF safety
• Transfusion practices
LARGE evidence gaps remain even in 2026 #NephJC
T3l
Transfusion strategy reminder:
✔ Avoid transfusions in chronic asymptomatic anemia
✔ Consider transplant candidacy
✔ Look at Hb trends, not single values
Nuanced decision-making emphasized #NephJC
T3k
KDIGO highlights persistent uncertainty:
👉 When to start therapy
👉 Optimal Hb targets
👉 Minimizing drug-related adverse effects
Despite decades of research, anemia care still evolving.
Any thoughts? #NephJC
T3j
Big theme from the closing sections:
Balancing efficacy, safety, patient preference & resource availability is key in CKD anemia management
One-size-fits-all anemia care doesn’t work globally. Improved data is needed (no 1 or 2A/B/C recs in all of guidelines)
😏👀#NephJC
T3i
KDIGO 2026 emphasizes:
👉 Guidelines should inform, not dictate anemia care
👉 Individual patient context, preferences & clinical judgment remain central
👉 Less protocol, more personalization 💥#NephJC
yeah, numbers are helpful, but real-life symptoms often drive patient experience
a bit frustrating that our options are somehow limited beyond optimizing dialysis or transplant #nephJC
T3h
Biggest Agreement?
Most clinicians seem aligned on:
✔ Iron optimization first
✔ Avoid unnecessary transfusions
✔ Individualized care
Anything else? #NephJC
T3g
KDIGO 2026 anemia guidelines still reflects lessons from classic ESA trials: CHOIR, CREATE & TREAT where higher Hb targets were linked to higher CV/stroke risk (and many never reached their higher targets).
Those studies continue to shape today’s conservative Hb goals #NephJC
T3f
And for the biggest controversy...
What sparks the most debate in anemia management?
A. ESA conservatism
B. HIF, limited initiation
C. Iron thresholds
D. Transfusion timing
E. Other (specify)
Cast your vote & defend your choice! #NephJC
More than a QoL number with a score, actual symptoms do matter
But I don’t have a fix for most of them
Nocturnal HD
Maybe HDF
A transplant
Other things are moving the deck chairs
#NephJC
T3e
Biggest Practice Change For You?
Quick Poll:
What has changed most for you after KDIGO 2026?
A. Iron thresholds
B. ESA targets
C. HIF use
D. Monitoring strategy
E. Other (specify)
Drop your thoughts! 🤔 #NephJC
i concur. same story in my side of the world as well #nephJC
T3d
Iron metabolism:
• Hepcidin regulation controls iron availability
• Functional iron deficiency persists despite adequate stores
• Inflammation alters iron handling & limits EPO response
Future therapies may focus on iron absorption and mobilization, rather than just boosting EPO 🤔 #NephJC
