Claudia Alvarez Carreño

This talk is happening tomorrow—as part of the Protein Structure Evolution seminar!

Click here to register if you like cool science: tinyurl.com/prose-seminar2

Organized by @lacholt.bsky.social, @caro-rocha.bsky.social, @claudiaalcar.bsky.social, @zachary-ardern.bsky.social and myself.

Our next Talk will be "Protein Origami and the Hidden Rules of Functional Innovations"! March 11th, 5PM CET. Sign-up here: tinyurl.com/prose-seminar2

Logo for the Undiagnosed Diseases Network (UDN). It shows a the letter UDN is different colors that overlap to form the analogous colors.

Today is #RareDiseaseDay & we are celebrating by highlighting the invaluable work of the Undiagnosed Diseases Network (UDN)! Formed in 2020, it aims to solve the most challenging medical mysteries using advanced technologies. In this thread, we will highlight their use of the #zebrafish model. 1/5 🧪

Starting in less than an hour!

Register to join: tinyurl.com/prose-seminar2

A gouache painting of an owl with blue eyes facing towards the viewer

A pen and ink drawing of an owl perched on a branch with its eyes closed.

A haunting charcoal and chalk drawing of an owl perched on a branch in the night

If the hashtag #SuperBowl has you wondering where the superb owls are…we got you!

🦉Detail from Owl, 1601–1800. EA2012.344.b
🦉An owl on a branch, 1893–1898, Sir Edward Coley Burne-Jones (1833–1898). WA2015.68.29
🦉Owl, 1865, Arthur Burgess (1843–1886). WA.RS.RUD.046

meetings.embo.org/event/26-mic... Announcing the 2026 EMBO course in Computational and Experimental Microbiomics, to be held at Bath. The course brings together experiments and bioinformatics to study host-microbe interactions and co-evolution. Register now, or at least by 11 May, if interested :)

Curious about how life began? OoLEN is a global community for early-career researchers in origins of life and prebiotic chemistry. 🧬🌍 Connect with others across disciplines, find opportunities, and grow together. Join: oolen.org/join Tell us in the replies—what do you work on? #OriginOfLife

Next up in our ProSE seminar series: Vyacheslav Tretyachenko on alternative translation in the human proteome
Register to join: tinyurl.com/prose-seminar2
Past seminars: tinyurl.com/ProSE-videos

Come one, come all to the first Protein Structure Evolution talk of the year (Feb 10)!

Click here to register if you like cool science: tinyurl.com/prose-seminar2

Jointly organized by
@lacholt.bsky.social, @caro-rocha.bsky.social, @claudiaalcar.bsky.social, @zachary-ardern.bsky.social and myself.

Ancient amino acid sets enable stable protein folds Early proteins likely arose from a chemically limited set of amino acids available through prebiotic chemistry, raising a central question in molecular evolution: could such primitive compositions yie...

Can proteins fold and function with half of the amino acid alphabet?
Using only 10 residues, we designed stable, mutation-resilient structures—no aromatics or basics involved.
A minimalist foundation for ancient biology and synthetic design. tinyurl.com/37t8br4v
#ProteinDesign #OriginsOfLife

'They saw them on their dishes when eating': The mushroom making people hallucinate dozens of tiny humans Only recently described by science, the mysterious mushrooms are found in different parts of the world, but they give people the same exact visions.

With most psychedelic drugs, you never know what you're going to get. But this mysterious mushroom from China - without fail - causes users to hallucinate tiny people: crawling up walls, popping out from under furniture and marching under doors. www.bbc.com/future/artic...

#OtD 22 Jan 2018 legendary anarchist author Ursula K Le Guin died aged 88 in Portland, Oregon. An ardent feminist and advocate for diversity in literature and publishing, she won numerous awards for her work. We have made available some of her books here: shop.workingclasshistory.com/collections/...

FYI were starting weird structure/evolution/biology stuff at Glasgow University!

If you're interested let me know! Tell your friends!

CRYO www.jobs.gla.ac.uk/job/research...

BIOINFO www.jobs.gla.ac.uk/job/research...

TECHNICIAN www.jobs.gla.ac.uk/job/technici...

#science #hiring #evolution

Thrilled to introduce TEDLH, a library of profile HMMs built from TED’s structure-derived domain annotations of the AFDB.
Explore 765K HMMs capturing CATH superfamily diversity.

www.biorxiv.org/content/10.6...

The vault associates with membranes in situ The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...

Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??

#CellBiology #WTFology

www.biorxiv.org/content/10.6...

Protein Structure Evolution Seminar November 11, 5pm CET Title: AI-Powered Classification and Discovery Across the Protein Universe Speaker: Joana Pereira Organized by: Claudia Alvarez Carreno, Zachary Ardern, Lars Eicholt, Carolina Sanchez-Rocha, Sergio Romero-Romero and MD. Hassan Uz-Zaman

The next ProSE Seminar will be given by Joana Pereira @joanampereira.bsky.social (VIB, KU Leuven)
🗓️ November 11th, 5pm CET

Registration is now open: tinyurl.com/prose-seminar2
Please share!

Join our next ProSe seminar 11th November 5PM CET and follow us @proteinstructure.bsky.social!

Protein Structure Evolution (ProSe) Seminar is now on BlueSky! Every 2nd Tuesday, 4PM GMT.

Sign-Up: tinyurl.com/prose-seminar2

Organized by Claudia Alvarez Carreño, Zachary Ardern, Lars Eicholt, Carolina Sanchez-Rocha,
Sergio Romero Romero and Md. Hassan Uz-Zaman.

I'll be featured at the outreach event of the Science Café in Nijmegen 🇳🇱, talking about astrochemistry and the origins of life and its building blocks in space and on early Earth.
Stop by if you're in the area on Thu, Oct. 23, 7.45 PM. Admission is FREE, and there will be jazz! 🎶🎷🌌🔭☄🦠

596_25_LS_ESB_R1 Reference: 596_25_LS_ESB_R1 Job title: PhD student in computational biophysics and machine learning (R1, FPI)   About BSC   The Barcelona Supercomputing Center - Centro Nacion

Last week to apply to join our recently created lab as a PhD Student!
Join us to research about protein computational biophysics, evolution, machine learning , and human mutations!
Description and link to apply here:
www.bsc.es/join-us/job-...

The next Protein Structure Evolution Seminar will be given by Stephen Fried (JHU):

Title: “Who Cares About Protein Refolding Anyway?: Why Some Microbes Do and Others Don’t”
Date: October 14th, 5 pm CET
Registration link: tinyurl.com/prose-seminar2

How does catalysis emerge from non-catalytic domains?

In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead.

A striking case of catalysis evolving from binding.

The next Protein Structure Evolution Seminar will be given by Stephen Fried (JHU):

Title: “Who Cares About Protein Refolding Anyway?: Why Some Microbes Do and Others Don’t”
Date: October 14th, 5 pm CET
Registration link: tinyurl.com/prose-seminar2

Caribbean coral reefs are threatened by rising seas Modelling suggests that most Caribbean coral reefs will erode by the year 2100 as sea-level rise outpaces reef growth and limits potential reef restoration.

Modelling suggests that most Caribbean coral reefs will erode by the year 2100 as sea-level rise outpaces reef growth and limits potential reef restoration

go.nature.com/42229kK

Establishing a Fixed Time Period of Admission and an Extension of Stay Procedure for Nonimmigrant Academic Students, Exchange Visitors, and Representatives of Foreign Information Media Unlike most nonimmigrant classifications, which are admitted for a fixed time period, aliens in the F (academic student), J (exchange visitor), and most I (representatives of foreign information media...

ADD YOUR THOUGHTS ON LIMITING STUDENT VISA TO FOUR YEARS

Comment period ends September 29th

www.federalregister.gov/documents/20...

1/2

Piecing Together the History of Protein Folds From a Fragmented Evolutionary Record Abstract. Protein folds are structural units defined by the number, type, arrangement, and orientation of their core secondary structural elements. The uni

Happy to share Piecing Together the History of Protein Folds From a Fragmented Evolutionary Record 🧪
It appears as part of a Special Section in @genomebiolevol.bsky.social organized by @cpuentelelievre.bsky.social @proteinmechanic.bsky.social and J. Douglas

doi.org/10.1093/gbe/...

The ProSE seminars are back after a summer break. The next speaker is Nir Ben-Tal on "Contrastive learning unites sequence and structure in a global representation of protein space".
Date: September 9
Time: 5pm CET
Register here: tinyurl.com/prose-seminar2

Please share!
🧪 #mevosky

Shout-out to @caro-rocha.bsky.social, @lacholt.bsky.social, @zachary-ardern.bsky.social, @romeritos.bsky.social and @hassanzaman.bsky.social

The ProSE seminars are back after a summer break. The next speaker is Nir Ben-Tal on "Contrastive learning unites sequence and structure in a global representation of protein space".
Date: September 9
Time: 5pm CET
Register here: tinyurl.com/prose-seminar2

Please share!
🧪 #mevosky

Puente-Lelievre et al. have systematically reviewed how protein structures can be used to trace evolutionary histories. This rapidly advancing field has not yet caught up with the burgeoning databases of high quality protein structure predictions provided by AlphaFold and other tools.

In a new GBE Review, @cpuentelelievre.bsky.social @proteinmechanic.bsky.social & J. Douglas give an overview on protein structural phylogenetics, how to obtain evolutionary insights from structural data, and key applications and future directions.

🔗 doi.org/10.1093/gbe/evaf139

#genome #evolution