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Tom Mathers

@tom-mathers

Evolutionary biologist. Genomics, aphids and gardening. Senior Computer Biologist at Wellcome Sanger Institute.

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18.11.2024
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Latest posts by Tom Mathers @tom-mathers

New preprint on pop #genomics of #spittlebugโ€”the main insect vector of Xylella, the bacterium that has ravaged olive groves in southern Italy ๐Ÿ‡ฎ๐Ÿ‡น ๐Ÿซ’

Take-home: problematic insect vector may be less widespread than initially thoughtโ€”important implications for disease control ๐Ÿ’ฅ

๐Ÿ‘‡

16.12.2025 14:49 ๐Ÿ‘ 24 ๐Ÿ” 19 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Whole-Genome Population Genomics Reveals Lineage Structure and Adaptive Potential of Philaenus spumarius, the Principal Vector of Xylella fastidiosa in Europe https://www.biorxiv.org/content/10.64898/2025.12.12.693891v1

15.12.2025 00:32 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1

We have a new preprint!
In this study, we use #genomic data to uncover population structure and adaptive potential in the meadow #spittlebug, the main European #vector of #Xylella fastidiosa.

16.12.2025 12:50 ๐Ÿ‘ 19 ๐Ÿ” 10 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
Photo of Bradysia coprophila by Sam Ebdon

Photo of Bradysia coprophila by Sam Ebdon

Does anyone have a photo of Charles W. Metz by any chance? He originally isolated the Holo2 line of Bradysia coprophila we still use after more than 100 years after their original capture.

18.11.2025 12:21 ๐Ÿ‘ 1 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Join us! ๐Ÿงฌ๐Ÿชฐ๐ŸŽ‰๐Ÿ”ฌ

We are currently advertising two #PhD projects to study the #evolution, #development and #genomics of sexual traits in stalk-eyed flies.

Deadline for applying is Wednesday, January 7, 2026. Get in touch for more info!

17.11.2025 15:58 ๐Ÿ‘ 60 ๐Ÿ” 62 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 1
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Retrocopy formation and domestication shape genome evolution in sloths and other xenarthrans Xenarthrans, comprising sloths, anteaters, and armadillos, represent one of the most morphologically and physiologically specialised mammalian clades, yet the genomic basis of their adaptations remain...

Preprint Alert! ๐Ÿฆฅ
We produced complete genomes for 2 Xenarthra and placed them in a mammalian comparative framework. We found that Xenarthra harbour the largest number of retrocopies in mammals! www.biorxiv.org/content/10.1...

02.10.2025 21:16 ๐Ÿ‘ 19 ๐Ÿ” 15 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Second cut of the year for the rosemary hedge. The most fragrant job in the garden!

04.10.2025 10:01 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Now out! Paper led by @philmor1964.bsky.social and the The Cetacean Genomes Project. An effort by many, we present 13 new, high-quality reference genomes for cetaceans ๐Ÿฌ๐Ÿ‹ following @vertebrategenomes.bsky.social and @ebpgenome.bsky.social standards for a group that is very hard to sample from.

18.07.2025 09:16 ๐Ÿ‘ 10 ๐Ÿ” 5 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Exploring the Satellitome of the Pest Aphid Acyrthosiphon pisum (Hemiptera, Aphididae): Insights Into Genome Organization and Intraspecies Evolution Abstract. Satellite DNAs (satDNAs), ubiquitous sequences in eukaryotic genomes, play a crucial role in genome organization, function, and evolution. The pe

Albuquerque characterized the satellitome of the pea aphid, with results suggesting that satDNAs contribute to genome evolution, biotype divergence, and the โ€œfast-Xโ€ effect.

๐Ÿ”— doi.org/10.1093/gbe/evaf104

#genome #satellitome

10.07.2025 16:18 ๐Ÿ‘ 3 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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๐Ÿ˜ฑ Simultaneously curating all 8 haplotypes of octaploid Carpinus betulus (European hornbeam).

One set of chromosomes down, many more to go...

@sangerinstitute.bsky.social Darwin Tree of Life.

01.07.2025 19:52 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Great to see this out. Hopefully very useful assemblies for the community.

These were very challenging to assemble due to high heterozygosity and lots of recent repeat activity. Tom Heaven put in a huge effort with manual #HiC #curation to get them in good shape.

30.06.2025 08:43 ๐Ÿ‘ 9 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Heaven @saskiahogenhout.bsky.social et al. generated chromosome-level genomes for three psyllid species that are plant disease vectors, revealing detoxification gene expansions and genetic substructure across Europe.

๐Ÿ”— doi.org/10.1093/gbe/evaf116

#genome #entomology

30.06.2025 07:42 ๐Ÿ‘ 12 ๐Ÿ” 8 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 1
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Helenium Moerheim Beauty doing well in the dry conditions.

28.06.2025 07:06 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Join us on the Wellcome Genome Campus of the Sanger Institute and EBI for a symposium on biodiversity genomics from 27th-29th October! Abstract deadline on 14 July. There is also an option to join via Zoom, but in-person is much nicer if you can make it.

27.06.2025 13:57 ๐Ÿ‘ 16 ๐Ÿ” 11 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Veg plot poppies.

15.06.2025 10:34 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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First group three clematis flowers. Early this year due to the hot spring.

15.06.2025 10:32 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Spatio-temporal tracking of three novel transposable element invasions in Drosophila melanogaster over the last 30 years Abstract. Transposable elements (TEs) are repetitive sequences capable of mobilizing within genomes, exerting a sigfinificant influence on evolution throug

super-happy, three TE invasions in Dmel during the last 30 years; the crazy thing - Transib1 spread in just 2-3years in global populations academic.oup.com/mbe/advance-... great work everyone @rpianezza.bsky.social @almoroscarpa.bsky.social @signor-molevol.bsky.social Anna Haider

11.06.2025 11:37 ๐Ÿ‘ 18 ๐Ÿ” 10 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Shropshire lad, grown from a cutting.

07.06.2025 18:12 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Thanks for posting @reviewcommons.org

If you're interested you can also find the reviewed version here:
doi.org/10.7554/eLif...

Really keen to get people's perspectives on the population genetics of reservoirs, and what they tell us about variation associated with emergent crop pathogens.

30.04.2025 09:01 ๐Ÿ‘ 3 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Starship giant transposable elements cluster by host taxonomy using k-mer-based phylogenetics Abstract. Starships are a recently established superfamily of giant cargo-mobilizing transposable elements in the fungal subphylum Pezizomyotina (phylum As

Our recent paper is out where we propose kmer-based phylogenetics for fungal Starship TEs (which are unalignable as highly variable). We think it could help with spotting bonafide HGT events (and suggest direction of transfer?)
doi.org/10.1093/g3jo...
@mcmullan0.bsky.social @norwichmicro.bsky.social

14.05.2025 15:18 ๐Ÿ‘ 37 ๐Ÿ” 21 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 1

Our paper on phylogenetics of fungal Starship TEs is now on the cover of the June issue of Genetics @genetics-gsa.bsky.social ๐Ÿ™‚
academic.oup.com/genetics/iss...

@mcmullan0.bsky.social @earlhaminst.bsky.social @rothamsted.bsky.social

04.06.2025 13:09 ๐Ÿ‘ 11 ๐Ÿ” 6 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1
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Best-practice guidance for Earth BioGenome Project sample collection and processing: progress and challenges in biodiverse reference genome creation Abstract. The Earth BioGenome Project has the extremely ambitious goal of generating, at scale, high-quality reference genomes across the entire Tree of Li

New pub on genome sample collection and processing: "Best-practice guidance for Earth BioGenome Project sample collection and processing: progress and challenges in biodiverse reference genome creation"
academic.oup.com/gigascience/...

03.06.2025 15:25 ๐Ÿ‘ 6 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Starship giant transposable elements cluster by host taxonomy using k-mer-based phylogenetics. #TransposableElements #TEs #Kmer #Phylogenetics #Genomics #Bioinformatics #G3 ๐Ÿงฌ ๐Ÿ–ฅ๏ธ
academic.oup.com/g3journal/ad...

02.06.2025 17:06 ๐Ÿ‘ 29 ๐Ÿ” 24 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 2
Nancy Moran Contact

An update on open postdoc positions, in my group and the adjacent group of Howard Ochman, here at UT-Austin. #SymbioSky

Mine: insect-bacterial symbiosis with emphasis on intracellular endosymbionts and molecular mechanisms.
web.biosci.utexas.edu/moran/contac...

02.06.2025 20:26 ๐Ÿ‘ 17 ๐Ÿ” 23 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 2
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Unicore is now published on GBE ๐Ÿš€
Unicore rapidly identifies structural single-copy core genes from input species proteomes for phylogenetic analysis. Powered by Foldseek and ProstT5, Unicore enables linear-scale structure-based phylogeny of any given set of taxa. ๐Ÿงต1/n
๐Ÿ“ƒ doi.org/10.1093/gbe/evaf109

03.06.2025 06:54 ๐Ÿ‘ 68 ๐Ÿ” 31 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 2
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Back to the poop: the oldest hexapod scales discovered within a Triassic coprolite from Argentina Life on Earth nearly came to an end during the end-Permian mass extinction (EPME; c. 252 Ma). In its aftermath, the Triassic witnessed the adaptation โ€ฆ

Oh wow, a new lepidopteran fossil dated to 236 My! Along with a reanalysis of molecular data using the new calibration. Are Lepidoptera really older than 300 My?

www.sciencedirect.com/science/arti...

03.06.2025 06:53 ๐Ÿ‘ 26 ๐Ÿ” 12 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1
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Register your interest in participating in the Global Culicidae Reference Genomes Project We are seeking mosquito biologists around the world who would be interested in collecting and contributing specimens of any vector species that currently lacks a reference genome. Aim: We are aiming ...

if you have an interest in improving the genomic resources available for mosquitoes, please fill in our google form at tinyurl.com/MosquitoReferenceGenomes. please share this with colleagues who might be interested. thank you! [3/3]

24.02.2025 10:51 ๐Ÿ‘ 17 ๐Ÿ” 16 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0
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Roses

02.06.2025 16:51 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Rosa Charles de Mills with Geum Totally Tangerine.

24.05.2025 11:40 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Thanks!

The gene set in the current version is tailored for birds but no reason why this approach couldnโ€™t help with other species using a custom gene set. We started with birds as there had been a long-standing problem finding all the micros.

21.05.2025 19:27 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0