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Alfie Wearn

@alfiewearn

Research Associate at The Montreal Neurological Institute 🧠 | Studying Alzheimer's disease pathogenesis with neuroimaging | OHBM Communications Committee @ohbm-com.com | He/Him

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26.11.2024
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Latest posts by Alfie Wearn @alfiewearn

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Publication of the Year Award - Nomination Thank you for submitting your Nomination!

The Neuromodulatory Subcortical Systems PIA within @istaart.bsky.social is requesting nominations for the best paper of 2025 on neuromodulatory subcortical systems in Alzheimer's disease!! ISTAART members: promote the work of your colleagues (or yourself) here: alz.surveymonkey.com/r/Publicatio...

21.01.2026 19:07 πŸ‘ 8 πŸ” 7 πŸ’¬ 0 πŸ“Œ 1
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Newsletters and alerts The latest news and perspectives on the neuroscience topics that interest you most, direct to your inbox

Want to stay up to date on the latest developments in human neuroimaging research? Subscribe to the quarterly newsletter in partnership with the @ohbmofficial.bsky.social to receive news and announcements from both of our organizations: www.thetransmitter.org/newsletters-...

#neuroskyence

12.01.2026 15:21 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

We just published a paper in PNAS, showing microstructural changes to the hippocampus in aging and presymptomatic Alzheimer's disease - in humans, in vivo.

We continue to show the value of structural MRI beyond simply measuring large-scale atrophy!

Read here: ow.ly/1NvV50XkXnX

09.11.2025 17:00 πŸ‘ 23 πŸ” 11 πŸ’¬ 0 πŸ“Œ 0
Heat maps for each of the five measures of structure mapped to the folded and unfolded surfaces of bilateral hippocampus, averaged across all participants. Cytoarchitectonic subfield boundaries are shown for reference.

Heat maps for each of the five measures of structure mapped to the folded and unfolded surfaces of bilateral hippocampus, averaged across all participants. Cytoarchitectonic subfield boundaries are shown for reference.

The search for early signs of Alzheimer's disease continues: Brain scans reveal microstructural changes in the hippocampus that signal early stages of the disease, including demyelination, increased iron deposition, and changes in water content. In PNAS: https://ow.ly/1NvV50XkXnX

31.10.2025 16:03 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1
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HippoMaps: multiscale cartography of human hippocampal organization - Nature Methods HippoMaps provides an open-source resource for studying the human hippocampus at different scales and with different modalities such as histology, fMRI, structural MRI and EEG.

HippoMaps: an open-source resource for studying the human hippocampus at different scales and with different modalities.
www.nature.com/articles/s41...
@jordandekraker.bsky.social @borismontreal.bsky.social @jclauneuro.bsky.social @neuroak.bsky.social @sofievalk.bsky.social @donnagift.bsky.social

03.10.2025 12:50 πŸ‘ 26 πŸ” 11 πŸ’¬ 0 πŸ“Œ 0

Healthy scientific communitiesβ€”built on open, engaged communicationβ€”are ready to take on the next challenges facing broader society.

Had a blast writing this piece with @dupre.science and @alfiewearn.bsky.social. Many thanks to the other past @ohbm-com.com chairs for their feedback and support!

16.09.2025 19:31 πŸ‘ 3 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
Reporter, The Transmitter The Transmitter offers up-to-date news and analysis of the field of neuroscience and is dedicated to helping scientists at all career stages stay current and build connections. Our award-winning news ...

Our award-winning news team is looking for an enthusiastic trade journalist to join our fast-paced newsroom in NYC. This is an excellent opportunity for a science journalist to develop a beat in the field of neuroscience. For more info, please visit: bit.ly/4nvAy4k

#neuroskyence

02.07.2025 16:04 πŸ‘ 9 πŸ” 10 πŸ’¬ 0 πŸ“Œ 2
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In @ohbmossig.bsky.social's first Open Datasets Special Issue paper, Wearn et al. introduce the OHBM Time Machine, a freely accessible archive of Annual Meeting content on YouTube: doi.org/10.52294/001...

@alfiewearn.bsky.social @sitek.bsky.social @sofievalk.bsky.social @stephforkel.bsky.social

27.06.2025 07:23 πŸ‘ 17 πŸ” 11 πŸ’¬ 1 πŸ“Œ 2
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#OHBM2025 !

Let's chat about how noradrenergic system health influences brain network segregation.

Poster #0916 today and tomorrow (Wed-Thurs)

See you there this afternoon!

25.06.2025 01:43 πŸ‘ 5 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Last chance to sign up to a Communications Competition at #OHBM2025!

Choose from:
πŸ“Š A Best Figure Competition
πŸ—£οΈ 3-Minute Chalk Talk Competition

⭐ See here for more details, or to sign up for one or both competitions:
forms.gle/HE8GUxWyYS4o...

13.06.2025 12:32 πŸ‘ 1 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Postdoctoral position available in the Breton-Provencher Lab at UniversitΓ© Laval to study neuromodulatory systems and foraging behavior – Canadian Association for Neuroscience

My laboratory at UniversitΓ© Laval in QuΓ©bec City, Canada, is looking for a postdoc to study how neuromodulatory systems impact cortical processing during foraging behavior. This fully-funded position offers a collaborative environment in a great city. More infoπŸ‘‡

can-acn.org/postdoctoral...

02.06.2025 14:59 πŸ‘ 20 πŸ” 22 πŸ’¬ 0 πŸ“Œ 0

All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!

23.05.2025 17:56 πŸ‘ 2259 πŸ” 1320 πŸ’¬ 34 πŸ“Œ 31

Going to #OHBM2025 in Brisbane?

We're accepting entries for *two in-person science communication competitions* at the annual meeting:
πŸ“Š A Best Figure Competition
πŸ—£οΈ 3-Minute Chalk Talk Competition

⭐ See here for more details, or to sign up for one or both competitions:
forms.gle/1X9ccz2vpsRQ...

12.05.2025 14:26 πŸ‘ 11 πŸ” 10 πŸ’¬ 2 πŸ“Œ 1

I have an opening for a graduate student at @carleton.ca (Carleton University) in the Department of Cognitive Science for fall 2025. Project is a multimodal MRI study examining how Hearing Loss affects cognition in older adults - contact me with a CV if you’re interested & have relevant expertise!

04.04.2025 22:33 πŸ‘ 15 πŸ” 15 πŸ’¬ 2 πŸ“Œ 0

There's a stream of excellent papers in @apertureohbm.bsky.social being published!

Check them out: apertureneuro.org

Submit your own
+code
+data
+open science
+imaging studies+

Quick turnaround, a devoted ed board, and lowest APC around.

And you'll support @ohbmofficial.bsky.social

share pls!

22.03.2025 14:28 πŸ‘ 13 πŸ” 6 πŸ’¬ 0 πŸ“Œ 2
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There are days in life that shake you.

I’m shattered πŸ’” to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧡

18.03.2025 23:27 πŸ‘ 1998 πŸ” 830 πŸ’¬ 93 πŸ“Œ 91
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Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer's disease Early detection of pathological changes in Alzheimer's disease (AD) has garnered significant attention in the last few decades as interventions aiming…

I was privileged to collaborate with the brilliant StΓ©fanie Tremblay on her project, just published in Neurobiology of Aging:

Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer's disease

bit.ly/3Rb3QWW

16.03.2025 16:25 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1
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The statistical error that just keeps on coming | Ben Goldacre Ben Goldacre: The same statistical errors – namely, ignoring the "difference in differences" – are appearing throughout the most prestigious journals in neuroscience

Anyone know if neuroscientists stopped doing this www.theguardian.com/commentisfre...

14.03.2025 11:33 πŸ‘ 12 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
Neurosalience #S5E10 with Simon Eickhoff - From Big Data to Biomarkers
Neurosalience #S5E10 with Simon Eickhoff - From Big Data to Biomarkers YouTube video by Organization for Human Brain Mapping

A new #Neurosalience episode is out! 🧠

From Big Data to Biomarkers
with Peter Bandettini @fmri-today.bsky.social and Simon Eickhoff @sbe.bsky.social

youtu.be/z91SiENsgF8

06.03.2025 11:50 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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..and another one! 🀩 Join us for a great webinar in cooperation with the @istaart.bsky.social NSS PIA on studying neuromodulatory subcortical nuclei with multimodal MRI!
πŸ“…Date: April 9 - 10:00 am CT
πŸ’»Register here: alz-org.zoom.us/webinar/regi...

28.02.2025 15:09 πŸ‘ 8 πŸ” 4 πŸ’¬ 1 πŸ“Œ 1

The network of Alzheimer's Disease Research Centers is one of the most amazing NIH projects of all time: 33 sites collaborating to fight Alzheimer's in the lab and in the clinic at the same time. All of it in turmoil because the new funding is blocked.

03.03.2025 23:36 πŸ‘ 5 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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Inside the Collapse at NIH Administration officials pressured NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.

By @katherinejwu.com

"The NIH... supported 99 percent of the drugs approved in the U.S. from 2010 to 2019. The agency has had a hand in β€œnearly all of our major medical breakthroughs over the past several decades,”

The NIH is in a struggle for its (and our) lives. This is existential to America:

27.02.2025 17:29 πŸ‘ 814 πŸ” 490 πŸ’¬ 11 πŸ“Œ 28
sreenshot from the new york times reporting that Stanford University’s provost is talking about how the loss of funding from national institutes of health funding will cost the university $160 million. that’s not the way to get this changed β€” the people think β€œstanford is rich; no big deal.” leaders need to talk about what this will cost the public

sreenshot from the new york times reporting that Stanford University’s provost is talking about how the loss of funding from national institutes of health funding will cost the university $160 million. that’s not the way to get this changed β€” the people think β€œstanford is rich; no big deal.” leaders need to talk about what this will cost the public

for pity’s sake, I am BEGGING university leaders to stop framing this issue in terms of what this will cost the university. people dont care!

EXPLAIN WHAT THIS WILL COST THE PUBLIC: closed hospitals and clinics, skipped treatments, loss of access to experimental drugs, unemployment, recession

09.02.2025 22:00 πŸ‘ 10538 πŸ” 2782 πŸ’¬ 138 πŸ“Œ 124
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Interview with Dr. Rosanna Olsen, 2024 Winner of the Diversity & Inclusivity Champion Award β€” OHBM Communications Author: Ashley Tyrer Editor: Simon R. Steinkamp

New blogpost from our OHBM 2024 award winner series! 🧠

Dr. Rosanna Olsen @rosannaolsen.bsky.social, winner of the 2024 Diversity and Inclusivity Champion Award, reflects on her vision for a more inclusive scientific community.

Read here: www.ohbm-com.com/blog/55ubbep...

17.02.2025 14:31 πŸ‘ 11 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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NIH and Its Agencies Are Being Smothered In recent days I have been inundated by reports out of HHS...

NIH and Its Agencies Are Being Smothered talkingpointsmemo.com/edblog/nih-a...

14.02.2025 16:40 πŸ‘ 182 πŸ” 70 πŸ’¬ 5 πŸ“Œ 4

Now over 900 signatures. Please keep signing and sharing to send a clear message to the Royal Society that we want them to stand up for values that we all hold dear: docs.google.com/forms/d/e/1F...

12.02.2025 20:30 πŸ‘ 197 πŸ” 101 πŸ’¬ 1 πŸ“Œ 12
Neurosalience #S5E8 with Mac Shine - Focusing on the nexus of subcortex-cortex interactions
Neurosalience #S5E8 with Mac Shine - Focusing on the nexus of subcortex-cortex interactions YouTube video by Organization for Human Brain Mapping

A new #Neurosalience episode is out!

Focusing on the nexus of subcortex-cortex interactions
with @fmri-today.bsky.social and Mac Shine (@macshine.bsky.social)

youtu.be/73X8bld4jB8

05.02.2025 18:09 πŸ‘ 2 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

To help you expand your brain mapping network here on Bluesky, we have initialized an OHBM Neurosalience Podcast starter pack! πŸ§ πŸ¦‹ Please feel free to comment if we've missed you or others out.

Listen to the Neurosalience podcast here: open.spotify.com/show/1d5umtP...

go.bsky.app/7gDbeAm

27.01.2025 13:18 πŸ‘ 15 πŸ” 8 πŸ’¬ 0 πŸ“Œ 0
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⁉️Does an MRI scanner always need to be so powerful? To kick off the year 2025, we at Brain Bites share the work of @asorby_adams and @NeuroSpin_91 With Low-field MRI and High-field MRI www.ohbm-com.com/brain-bites 🧠 #OHBM #BrainBites

21.01.2025 16:54 πŸ‘ 7 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0