S. Kubo

The ATPase asymmetry: Novel computational insight into coupling diverse FO motors with tripartite F1 ATP synthase, a crucial enzyme for cellular bioenergetics, operates via the coordinated coupling of an FO motor, which presents variable symmetry, and a tripartite F1 motor. Despite extensive research...

The ATPase asymmetry: Novel computational insight into coupling diverse FO motors with tripartite F1: Biophysical Journal www.cell.com/biophysj/ful...

Dynein-2 is tuned for the A-tubule of the ciliary doublet through tubulin tyrosination Eukaryotic cilia and flagella are thin structures present on the surface of cells, playing vital roles in signaling and cellular motion. Cilia structures rely on intraflagellar transport (IFT), which ...

We have posted our new #preprint regarding the track recognition mechanism of dynein-2 that works in #cilia on bioRxiv @biorxivpreprint.bsky.social!!
www.biorxiv.org/content/10.1...
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Optical Control of Microtubule Accumulation and Dispersion by Tau-Derived Peptide-Fused Photoresponsive Protein Microtubules, a major component of the cytoskeleton consisting of tubulin dimers, are involved in various cellular functions, including forming axons and dendrites of neurons and retaining cell shapes...

Collaborative paper of regulation of microtubule superstructures by light is now published in JACS Au!
pubs.acs.org/doi/10.1021/...

www.biorxiv.org/content/10.1...
Our new research findings have been published. Using cryo-ET and MD simulations, we confirmed that the tyrosination and detyrosination of microtubules control dynein-2 motility, thereby facilitating the formation of the IFT train.

Theoretical insights into rotary mechanism of MotAB in the bacterial flagellar motor Many bacteria enable locomotion by rotating their flagellum. It has been suggested that this rotation is realized by the rotary motion of the stator unit, MotAB, which is driven by proton transfer across the membrane. Recent cryo-electron microscopy studies have revealed a 5:2 MotAB configuration, in which a MotB dimer is encircled by a ring-shaped MotA pentamer. Although the structure implicates the rotary motion of the MotA wheel around the MotB axle, the molecular mechanisms of rotary motion and how they are coupled with proton transfer across the membrane remain elusive.

Theoretical insights into rotary mechanism of MotAB in the bacterial flagellar motor: Biophysical Journal www.cell.com/biophysj/ful...

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