Tommy Vierbuchen

The Jackson Laboratory's Bill Skarnes wins top international prize in transgenic science Skarnes' groundbreaking contributions to transgenic technologies and genome engineering made a generation of experiments possible

JAX is proud to announce that Professor Bill Skarnes has been selected as the 17th recipient of the International Society for Transgenic Technologies (@transtechsociety.org) Prize, one of the highest honors in the field. 🧬 🧪

Laboratory Assistant II - Human Genetics - UCLA Health Careers - Job #29031 - Los Angeles, CA Take a look at a great career opportunity where you can make a real difference at UCLA Health

We're hiring villagers!

We are looking for a lab technician to help us discover how gene-by-environment interactions shape the developing brain via in vitro cell villages. Please DM me or visit our website at mfwellslab dot com for more info.

Deadline to apply is March 11th: tinyurl.com/34seyjaj

Major findings from paper linked below:

NEXT TUE: DDD seminar, Feb. 17, 2026 @ 1PM Eastern US: Dr. Annerieke Sierksma (in Dr. Bart De Strooper's group at KU Leuven) will share her recent work on "Polygenic risk for Alzheimer’s disease shapes microglial inflammatory and antigen-presentation programs in vivo". carlocolantuoni.org/seminar

Structural basis for CTCF-mediated chromatin organization https://www.biorxiv.org/content/10.64898/2026.02.06.704447v1

For anyone interested in the history of molecular biology, I cannot recommend Judson's The Eighth Day of Creation highly enough. One of the great book on the history of science.

I have two copies because a actually wore out the first one (paperback)

www.cshlpress.com/default.tpl?...

Developmental Diversity in a Dish Seminar Series - YouTube A virtual seminar series focusing on stem cell models and functional variation across human iPSC lines. Monthly virtual seminar series, held on one Tuesday o...

Today's DDD seminar "A systematic study of morphogen patterning and its reproducibility in human neural organoids" given by Nadezhda Azbukina (from Dr. Barbara Treutlein's group in Basel) is now online at www.youtube.com/playlist?lis...

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.353138.125.abstract

Josh Mendell HHMI

Dissecting gene regulatory networks governing human cortical cell fate - Nature Systematic screening of transcription factors reveals conserved mechanisms governing cortical radial glia lineage progression across primates and provides a framework for functional dissecti...

1/ Our new study, led by Jingwen Ding, examines the role of transcription factors during human neurogenesis to identify gene regulatory networks influencing cell fate, maturation, and subtype specification
www.nature.com/articles/s41...

B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing https://www.biorxiv.org/content/10.64898/2026.01.16.699998v1

Bringing African ancestry into cellular neuroscience Two independent teams in Africa are developing stem cell lines and organoids from local populations to explore neurodevelopmental and neurodegenerative conditions.

Very important research to establish African ancestry cell lines! #Neuroskyence www.thetransmitter.org/cellular-neu...

Scaling perturbations: beyond genome-scale CRISPR screens https://www.biorxiv.org/content/10.64898/2026.01.16.699948v1

Registration for the 2026 NY Area Population Genetics meeting is now open, at events.simonsfoundation.org/e0mEoL?rt=8k.... Registration is free but required; if you are submitting an abstract, note that the deadline is *January 30th*.

System-wide extraction of cis-regulatory rules from sequence-to-function models in human neural development https://www.biorxiv.org/content/10.64898/2026.01.14.699402v1

There's still time to apply to be a 2026 @dev-journal.bsky.social Pathway to Independence fellow

For those about to apply for their first independent academic position, the programme offers

- mentoring
- leadership training
- profile rising
- networking

journals.biologists.com/dev/pages/pi...

Machine Learning enables efficient and effective affinity maturation of nanobodies https://www.biorxiv.org/content/10.64898/2026.01.11.698911v1

Why do some individuals defy their polygenic score?

In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference?

www.medrxiv.org/content/10.6...

We had a great experience publishing in Development (doi.org/10.1242/dev....). High-quality reviews, quick turnaround, and our editor (Jim Wells) was very helpful and provided feedback about the reviewers comments.

Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons of the cerebral cortex Nature Neuroscience - Distinct neuron subtypes compartmentalize specific functions by differentially localizing and translating specific RNAs. This work identifies dynamic subtype- and...

Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons in the cerebral cortex. rdcu.be/eXuwg

NIPBL-mediated 3D genome folding translates enhancer priming into gene activation and safeguards lineage fidelity during embryonic transitions #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2025.12.30.686824v1

As usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-...
Know of a relevant event that’s missing? Please reply below

Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits https://www.biorxiv.org/content/10.64898/2025.12.23.696273v1

Trans-regulation of heterochromatin underlies genetic variation in 3D genome contacts Genetic variation drives phenotypic diversity and disease susceptibility. Trans -acting genetic variation coordinates genome-wide chromatin changes, yet the molecular mechanisms underlying this regula...

Very interesting pre-print from Chris Baker's lab at JAX on the mechanistic link between trans-acting genetic variants and heterochromatin formation in mice. #heterochromatin #epigenetics #variants www.biorxiv.org/content/10.6...

Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo Enhancers control tissue-specific gene expression across metazoans. Although deep learning has enabled enhancer prediction and design in mammalian cell lines and invertebrate systems, it remains uncle...

Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)

One of the best reviews I read this year...

CAD-C reveals centromere pairing and near-perfect alignment of sister chromatids Three-dimensional (3D) genome organization plays a central role in gene regulation, chromatin folding, and genome stability. Although chromosome-conformation capture (3C)-derived methods have revoluti...

Hi all!
We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids.

www.biorxiv.org/content/10.6...

#3DGenome #chromatin #Cohesin #centromere

Tommy Vierbuchen @tvierbuchen.bsky.social shared his work with us today: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". see the recording at: www.youtube.com/playlist?lis... (more info at www.carlocolantuoni.org/seminar)

Generating 3D mouse organoids for cortex development and evo-devo How do cis-regulatory differences, across mouse subspecies over timescales, shape cell-type specification and maturation during corticogenesis? In this issue of Developmental Cell, Medina-Cano et al. ...

Nice preview of our paper by Hanwen Yu and Yan Liu.

Generating 3D mouse organoids for cortex development and evo-devo: Developmental Cell www.cell.com/developmenta...

academicjobs.uchicago.edu/positions/16...

1.5-story house that backs up to a canal and has a brick street in front

I know Americans overly romanticize Europe but I still think moving to a little house on a canal in the Netherlands could solve like 82% of my problems