Jay Hesselberth

Upset no one told me about Wild Pink. This would have been useful in 2025.

GitHub - rnabioco/2a-peptide-search: HMM models of the 2A peptide and DB search results HMM models of the 2A peptide and DB search results - rnabioco/2a-peptide-search

I have been trying to onboard the 2A peptide pHMM models into Pfam to no avail. If anyone has a contact there, I would appreciate an introduction for a discussion.

github.com/rnabioco/2a-...

This entire project would not have been possible with out HMMER.

bsky.app/profile/cryp...

Systematic identification and characterization of eukaryotic and viral 2A peptide-bond-skipping sequences Rao et al. identified thousands of previously unknown 2A peptides across both viruses and eukaryotes using an HMMER analysis. The authors further identified a unique class of 2A peptides, class B, who...

Excited to see this collaborative work with Olivia Rissland's lab finally out. We found lots of 2A peptides and an entirely new 2A class.

www.cell.com/cell-reports...

Any word on whether these are all NIAID grants? Or do they include neoepitope mRNA vaccine studies funded by NCI, etc?

In my experience REPORTER is not updated in real-time. Not sure it's a reliable measure of the effect.

GitHub - rnabioco/nihexporter: An R data package for NIH EXPORTER data An R data package for NIH EXPORTER data. Contribute to rnabioco/nihexporter development by creating an account on GitHub.

I just updated this R data package for NIH EXPORTER data. Can you file an issue with your approach for calculating ICR?

github.com/rnabioco/nih...

GitHub - rnabioco/nihexporter: An R data package for NIH EXPORTER data An R data package for NIH EXPORTER data. Contribute to rnabioco/nihexporter development by creating an account on GitHub.

Just released an update of an R data package for NIH funding data from 1985-2024.

github.com/rnabioco/nih...

GitHub - rnabioco/nihexporter: An R data package for NIH EXPORTER data An R data package for NIH EXPORTER data. Contribute to rnabioco/nihexporter development by creating an account on GitHub.

I maintain an R data package of NIH EXPORTER data. Updated last week.

github.com/rnabioco/nih...

And I forgot the default REPORTER search only lists active grants. This list is pretty long.

Technically speaking, your last point is incorrect.

(but the NIH REPORTER link doesn't go anywhere useful to confirm this is the same person; I inferred it from the abstract)

This is on a (very long) to-do list.

Also crossing "publish with your scientific grandfather" off my bucket list.

Nanopore sequencing of intact aminoacylated tRNAs Transfer RNAs (tRNA) are decorated during biogenesis with a variety of modifications that modulate their stability, aminoacylation, and decoding potential during translation. The complex landscape of ...

Here for my first post. Our new approach to study tRNA aminoacylation by nanopore sequencing. Started as a napkin sketch ~1 year ago! This was a fun one, congrats to @laurakwhite.bsky.social and Aleks.

www.biorxiv.org/content/10.1...