Sara DiTursi

Microbiota-Based Therapies Show Superior Outcomes for Recurrent C difficile Infection Systematic review finds FMT and standardized microbiome products outperform antibiotics in efficacy and safety.

Systematic review of 1,030 patients: FMT cured 70–91% of recurrent C. difficile cases vs 23–62% with antibiotics; microbiome products cut recurrence risk by up to 68% with favorable safety. #IDsky #MEDsky

Read more: www.contagionlive.com/view/microbi...

Estimation of Over 73,000 Children Born With Hepatitis C Annually Global modeling identifies vertical transmission burden and underscores need for maternal screening policies.

New global research estimates over 73,000 children are born each year with hepatitis C, with more than 23,000 still infected by age five. Most are never diagnosed. #IDsky #MEDsky

Read more: www.contagionlive.com/view/study-e...

🧵 Dengue is no longer just a tropical disease - it's showing up in Europe.

This season, France, Italy, and Portugal (Madeira) have already reported locally acquired dengue cases.

Check the latest #CDTR on #dengue here: bit.ly/3TQpDVu

#IdSky #EpiSky #MosquitoBorne #Prevention #PublicHealth

Measles cases surge to record high since disease was declared eliminated in the US | CNN There have been more measles cases in the US this year than any other since the disease was declared eliminated a quarter-century ago.

Falling childhood vaccine coverage and a large outbreak that was kindled in an undervaccinated pocket of West Texas have driven the US to a troubling milestone: There have been more measles cases in the US this year than any other since the the disease was declared eliminated a quarter-century ago

🌟 ABX Pearl of the Day: ertapenem hypoalbuminemia

❓ Q: My ICU patient with hypoalbuminemia has ESBL E. coli pyelonephritis, resistant to PO abx. He improved (afeb, WBC WNL, off pressors) after 3d of meropenem. Should I avoid narrowing to ertapenem?

#IDsky #medsky #meded #pharmsky #skyRX #AMSsky

In a study of 201 PWID, 33% in the MMU group initiated HCV treatment vs. 24% in usual care. Treatment completion: 16% (usual) vs. 10% (MMU); SVR12: 12% (usual) vs. 4% (MMU). Low retention noted.

#idsky

Happy ID Pharmacists day 🥳🥳‼️This year's theme is  "Innovation in ID: Pharmacists Leading the Way."  Please join the discussion on Bluesky with SIDP between 12-1 PM EST today 🦠🧫💊#IDPharmacistsDay, #SIDPAdvocacy, #FutureOfIDPharmacy, #PharmacistsLeadingChange, #IDXposts

📅 Today is #IDPharmacistsDay! 🦠 This day recognizes the importance of ID pharmacists and the contributions they make to patient care. Thank you for all you do! 👏 @sidpharm.bsky.social

sidp.org/IDPharmacist...

#SIDPAdvocacy, #FutureOfIDPharmacy, #PharmacistsLeadingChange

ID Pharmacists play an essential role in health systems. This #IDPharmacistsDay, learn five ways that pharmacists are being #AntibioticsAware via SIDP.

For more sharable resources, visit buff.ly/EbkVlbS.

💡 A: In stable FN patients with persistent fever of unknown origin, current NCCN and ECIL guidelines do not recommend changing empiric coverage for Gram-negative bacteria.

⏳ Time to defervescence may last 2-7 days (median of 5 days) for patients on appropriate initial antibiotic therapy. (3)

Nothing is better than seeing this study published just in time for ID Pharmacists Day! 🥳 #IDSky

#brucella #PEP 2 effective abx should be given: Doxycycline 100mg bid + Rifampin 600mg daily x 3 wks
-If cant use either doxy or rif: use tmp-smx
-Weekly sx check through 24 weeks post exposure
-serology at 0,6,12,18,24 weeks #idsky

To kick off a new series ID/AMS Reading Lists series, SIDP is here to help you "Hit 'Em with Your Best Nudge"! Check out this noticeable (and unnoticed) nudge comments in AMS! #IDSky #rxsky #pharmsky #AMSsky #medsky #SIDP #EvidenceBasedMedicine #IDPharmacy #Microbiology #Nudge #NudgeComments

Check out our article!

For herd immunity against measles, 92-95% of the population must be vaccinated.

As a live vaccine MMR can’t be given to pts who are immune suppressed (including pts receiving chemo/radiation or immunosuppression)

And it’s not effective in newborns.

So if you CAN get it, we REALLY need you to.

Together with leading science organizations, ASM filed an amicus brief calling for immediate restoration of NIH grants supporting early-career scientists. Read the press release: asm.org/press-releas...

We’ve Got the Cure for Hepatitis C: Most Kids Never Get It Many children with hepatitis C do not receive treatment.

“Fewer than 1 in 3 children with hepatitis C (HCV) see a clinician for care, and fewer than 1 in 8 receive treatment.”

www.medscape.com/viewarticle/...
#idsky #medsky

Looking to level up your ID & HIV knowledge? 📚🤓
We've got you covered! Join us for this month's ACCP ID PRN Journal Club where we will discuss optimal mgmt for invasive Candida infections & DoxyPEP!

Happening on Fri May 9th at 12pm CT via Zoom. Check your 📧 for login details! #IDSky

🙍‍♀️ w/Staph aureus BSI have high rates of mortality & metastatic infx (Think ❤️,🫁,🦴, & 🔩!). Huge shout out to these authors for succinctly summarizing A LOT of complex data! Truly a huge 🏋️‍♂️

👀 Figure 2 & Table 2

doi.org/10.1001/jama.2025.4288

#IDSky #rxsky #pharmsky #AMSsky #medsky #SIDP

New commentary in ICHE:

Infection prevention and control for measles in healthcare settings

Authors provide methods to ⏫ identification of measles cases, facilitate appropriate isolation, ⏬ exposures, & provide timely post-exposure prophylaxis

#IDSky

📄: www.cambridge.org/core/journal...

Wow! 😱

algorithm for post-hep c treatment follow up from the IDSA/AASLD guidelines att hcvguidelines.org

i know everything is awful and we may not even have access to these meds soon, but IDSA/AASLD have adopted an SVR4 for HCV tx!!
have been hoping for this for a while; will be SO much more likely to capture cures for my unhoused pts!!
#MedSky
#IDSky
#HCV

“Golden Hour” to Start Antibiotic in Suspected Sepsis Patients with suspected sepsis in the emergency department are twice as likely to survive at 28 days when antibiotics are started within 1 hour.

Patients with suspected sepsis in the emergency department are twice as likely to survive at 28 days when antibiotics are started within 1 hour. #IDsky #Medsky

Providers' Perspectives on Implementation of Low-Threshold HCV Treatment in New York State: A Qualitative Study Global study data show injection drug use is driving upwards of 79% of all new HCV cases in high-income countries. Low-threshold models can engage vulnerable populations in treatment to achieve HCV elimination targets.

Providers' Perspectives on Implementation of Low-Threshold HCV Treatment in New York State: A Qualitative Study

✅ Just Accepted
#IDSky

Check out this article we wrote!

A visual representation of the uncertain treatment duration for patients with bloodstream infection

In patients with bloodstream infection, early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. Research findings on treatment duration in hospitalized patients are summarized in a new Quick Take video. youtu.be/V68RQ6XwiKQ

#MedSky #PulmSky #IDSky

Public Comment: Complicated Urinary Tract Infections Published , 2/19/2025

Big news #IDSky! The @idsainfo.bsky.social opened a public comment period for the upcoming 2025 Updated #cUTI guidelines. The IDSA wants feedback from #HCPs and non-HCPs.

Public comment will end on Mar 19, 2025 at 5pm so check it out here: buff.ly/TqCJnz5

#pharmsky #rxsky #medsky #AMSsky #ICUsky

THIS IS INCREDIBLE! Cohen Children’s Medical Center has confirmed that it has successfully ELIMINATED sickle cell disease from Sebastien Beauzile, using the groundbreaking genetic treatment Lyfgenia. He has made HISTORY by becoming the FIRST in New York to be CURED of sickle cell anemia! 🧪🧵⬇️

The World’s Deadliest Infectious Disease Is About to Get Worse By retracting foreign aid, President Trump could make tuberculosis untreatable again.

The sudden U.S. cuts left no time for other nations to react, creating an immediate crisis. TB programs are now at risk of collapse, threatening decades of progress. Drug resistance will surge, endangering millions. Urgent action is needed. #TB #GlobalHealth #AMR
www.theatlantic.com/health/archi...

Wow!! 🤩