But can they scratch their backs with them?😂
21.01.2026 08:08
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So true!
26.10.2025 14:45
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contact me or @csoneson.bsky.social if you want more details
12.09.2025 07:52
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The Max Burger Prize 2025 goes to Josip Ahel (@aheljo.bsky.social), Aparna Pandey & Michaela Schwaiger for adding a key piece to the puzzle of how cells protect the DNA from “jumping genes.” Read more at www.fmi.ch/news-events/...
17.09.2025 08:22
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We are hiring-join us!
08.09.2025 10:31
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🚨 Job Alert: we seek a Lab Manager for @juliabatki.bsky.social's new group (start Mar 2026), which will study cell fate regulation during organ development. Join the Batki's group to drive experiments & lab operations! Apply at: www.fmi.ch/education-ca...
02.09.2025 09:03
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Remodeling Activity of ChAHP Restricts Transcription Factor Access to Chromatin
Transcription in eukaryotes is regulated by chromatin-based mechanisms that control nucleosome occupancy, chromatin modifications, and transcription factor binding. We have previously shown that the transcription factor ADNP forms the ChAHP complex with the chromatin remodeler CHD4 and HP1 proteins, acting as a site-specific regulator of transcription and antagonist of CTCF binding. However, the molecular basis of these functions remained unclear. Here, we demonstrate that the CHD4 subunit is essential to antagonize CTCF and silence transcription of transposons, while HP1 proteins are dispensable. Although the remodeling activity of CHD4 is not required for ChAHP chromatin association, it is critical for both transposon repression and CTCF antagonism. Our findings support a model wherein ADNP recruits chromatin remodeling activity in a sequence-specific manner, enabling transcriptional control and local modulation of chromatin architecture. ### Competing Interest Statement The Friedrich Miescher Institute for Biomedical Research (FMI) receives significant financial contributions from the Novartis Research Foundation. Published research reagents from the FMI are shared with the academic community under a Material Transfer Agreement (MTA) having terms and conditions corresponding to those of the UBMTA (Uniform Biological Material Transfer Agreement). Novartis Research Foundation, n.a. Swiss National Science Foundation, grant 310030_188835
🧵 New preprint!
How does a chromatin remodeler know where to act?
In our latest study, we show how the transcription factor ADNP targets CHD4 remodeling activity to silence transposons and block CTCF.
👇 A thread on the ChAHP complex and how it weaves chromatin
🧬🔬🧵
www.biorxiv.org/content/10.1...
06.07.2025 16:25
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More ChAHP within the same week! Check out the work from @aheljo.bsky.social dissecting the molecular activities within the complex
06.07.2025 14:30
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Remodeling Activity of ChAHP Restricts Transcription Factor Access to Chromatin
Transcription in eukaryotes is regulated by chromatin-based mechanisms that control nucleosome occupancy, chromatin modifications, and transcription factor binding. We have previously shown that the transcription factor ADNP forms the ChAHP complex with the chromatin remodeler CHD4 and HP1 proteins, acting as a site-specific regulator of transcription and antagonist of CTCF binding. However, the molecular basis of these functions remained unclear. Here, we demonstrate that the CHD4 subunit is essential to antagonize CTCF and silence transcription of transposons, while HP1 proteins are dispensable. Although the remodeling activity of CHD4 is not required for ChAHP chromatin association, it is critical for both transposon repression and CTCF antagonism. Our findings support a model wherein ADNP recruits chromatin remodeling activity in a sequence-specific manner, enabling transcriptional control and local modulation of chromatin architecture. ### Competing Interest Statement The Friedrich Miescher Institute for Biomedical Research (FMI) receives significant financial contributions from the Novartis Research Foundation. Published research reagents from the FMI are shared with the academic community under a Material Transfer Agreement (MTA) having terms and conditions corresponding to those of the UBMTA (Uniform Biological Material Transfer Agreement). Novartis Research Foundation, n.a. Swiss National Science Foundation, grant 310030_188835
preprint alert: www.biorxiv.org/content/10.1...
06.07.2025 11:55
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Check out our latest preprint on the regulation of SINE retrotransposons! 🐭
03.07.2025 08:26
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Earlier today @csoneson.bsky.social from @fmiscience.bsky.social gave a great keynote at this year's #gbcc2025 conference @bioconductor.bsky.social @galaxyproject.bsky.social
25.06.2025 20:49
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Thanks Yehu for visiting, it was great to see you again and we really enjoyed hearing about your exciting science!
13.06.2025 06:16
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That sounds like a great idea and I hope you will enjoy it. Come visit Basel, it’s not far!
05.05.2025 08:16
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Friedrich Miescher Institute, open position
Friedrich Miescher Institute, open position
Permanent position for a Linux Systems Engineer: Are you fond of scientific computing and/Linux/HPC and would enjoy working in a vibrant research environment? Have a look at our job opening: www.fmi.ch/education-ca...
15.01.2025 13:44
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Friedrich Miescher Institute, open position
Friedrich Miescher Institute, open position
Our IT (at @fmiscience.bsky.social) group is looking for a Linux Systems Engineer. This is an interesting opportunity to work in a diverse research environment.
www.fmi.ch/education-ca...
15.01.2025 14:10
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📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...
16.12.2024 11:50
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