Rémi Fronzes

Optical illusion of a woman bent over some papers. Her sunglasses are pushed up and she is wearing a hair band so the top of her head looks exactly like a Muppet face

Sorry I know the world is in a terrible fix but I've been laughing at this for ten minutes now

Figure 1. Cryo-EM of abundant protein complexes in native membranes.

Figure 2. Cryo-EM of membrane proteins in vesicles.

Figure 3. 3D reconstruction of V-ATPase in native synaptic vesicle membranes.

Figure 4. Generation of membrane vesicles for structure determination of proteins in their native lipid bilayer.

I've written a review on what I think is an extremely exciting direction in cryo-EM:

Cryo-EM of endogenous membrane proteins in their native lipid bilayer

Open access in Quarterly Reviews of Biophysics:
doi.org/10.1017/S003...

Je ne sais pas si on doit en rire ou en pleurer…

Wow. Really really useful paper and also really awesome thread / summary.

Nor donated money to Donald Trump’s 2025 inauguration committee

Dario Amodei did not attend Donald Trump’s inauguration.

Just saying

Type IV secretion systems: reconciling diversity through a unified nomenclature This review presents a comprehensive overview of Type IV Secretion Systems (T4SSs), focusing on their structural, functional, and evolutionary diversity ac

Happy to share a new review proposing a unified nomenclature for T4SSs.
Great collaboration with Peter J Christie, Gabriel Waksman, Ronnie Per-Arne Berntsson and our team.
academic.oup.com/femsre/artic...
#T4SS#Microbiology

À l’ombre de la vieille dame : épisode 10/10 du podcast L'épopée de Lady Liberty AUDIO • L'épopée de Lady Liberty, épisode 10/10 : À l’ombre de la vieille dame . Une série inédite proposée par France Inter. Écoutez Face à l'histoire, et découvrez nos podcasts en ligne.

Série à écouter !

The political effects of X’s feed algorithm Nature - Among users initially on a chronological feed, 7 weeks of exposure to X’s algorithmic feed in 2023 shifted political attitudes and account-following behaviour in a more conservative...

Well, science confirms that X is a global propaganda machine ?

‘Nice shoes, mate’: we road test the brick-shaped £199 Lego Crocs Lego and Crocs have joined forces to create oversized Lego-shaped shoes. Are they as ridiculous as they sound? We sent our most podophilic writer to find out

1 April has come early this year.

Les crues et inondations en Lot-et-Garonne en images Rupture de digue et hébergement d’urgence à Aiguillon, routes et plaines englouties dans le Val de Garonne… Les images de ce samedi 14 février

C’est chez moi ! Bon courage à tous les Aiguillonais !

One on left is a black dog and above it the words “Reality”. Below it is “I chased a squirrel” One the right is a black dog and above it says “LinkedIn”. Below it says, Proud to announce that I effectively executed a rapid-response squirrel displacement strategy to mitigate potential yard intrusions. Humbled by the unwavering support of my family and local stakeholders. This experience reinforced the importance of vigilance, ownership, and continuous improvement. Looking forward to scaling this impact in future engagements.

😂

La couleur bleue aurait été naturelle

AI is not a peer, so it can’t do peer review If we still believe that science is a vocation grounded in argument, curiosity and care, we can’t delegate judgement to machines, says Akhil Bhardwaj

AI is not a peer, so it can’t do peer review.

To the point !

IRF2 deficiency disrupts pyroptosis, NK cell interferon-γ production and resistance to Francisella - EMBO Reports IRF2 plays an indirect role in inflammasome activation by regulating Caspase-4 and Gasdermin D (GSDMD) levels. However, the in vivo relevance of this regulatory circuit is unknown. We generate IRF2KO ...

IRF2 regulates both GSDMD expression and NK cells antibacterial functions. Check the latest paper from the lab @ciri-lyon.bsky.social published in @emboreports.org. IRF2 as a key immune regulator against our favorite bug, #Francisella tularensis! #inflammasome link.springer.com/article/10.1...

Save the date 🤩🤩🤩!

Our student-led Young Scientist Symposium will take place on the 4th & 5th of June this summer!

More information and registration available soon!

And @wikipedia.org is here on Bsky!

Give them a follow, and throw them a little cash to help their mission of being a resource of facts in a world where information is both becoming more critical and being more poisoned.

France Universités condamne les attaques formulées sur CNews France Universités condamne les attaques formulées sur CNews contre plusieurs universités le 27 janvier 2026.

🛑 Parce que l’Université est un pilier de la démocratie, elle doit être défendue contre celles et ceux qui entendent plonger notre pays dans la nuit.
franceuniversites.fr/actualite/fr...

Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections Macrophage activation is essential for innate immunity and antimicrobial defense. We show that Enterococcus faecalis suppresses macrophage activation …

Lactic acid lover? Check out @ronni.bsky.social 's new work in
@cp-cellhostmicrobe.bsky.social showing how Enterococcus faecalis-derived LA suppresses macrophage activation, in turn promoting bacterial persistence and polymicrobial wound infection in vivo.
www.sciencedirect.com/science/arti...

The party behind Kyle Rittenhouse and J6 think Alex Pretti's legal gun was the problem? Seriously?!?

Dear colleagues in science - it is time to stop normalising the emerging fascism of the US by attending conferences there as though everything is fine.

When cryo-EM modeling meets structure prediction Nature Structural & Molecular Biology, Published online: 23 January 2026; doi:10.1038/s41594-026-01744-4Accurately interpreting density maps into atomic models is a central yet challenging goal of cryo-EM. Two studies now reveal distinct ways in which protein structure prediction can be incorporated into cryo-EM model building to enable more accurate and robust automated construction of protein atomic models from density maps.

New online: When cryo-EM modeling meets structure prediction

looks very good to me !

For the French speaking people here.

I love that !

#microsky
Massive update of preprint with @polardlab.bsky.social!
Bacteria have evolved two systems to recombine extracellular DNA
www.biorxiv.org/content/10.1...
Kudos to lead authors Léo Hardy, Violette Morales and Clothilde Rousseau, and to outstanding Dalia's lab and @epcrocha.bsky.social
🧵⬇️

L’Agence nationale de la recherche (#ANR) est contrainte d’adapter temporairement ses activités dans le cadre des services votés. Le calendrier et la mise en œuvre des appels à projets, dans l’attente de l’adoption de la loi de finances pour 2026, sont précisés dans ce #communiqué ➡ bit.ly/3NyLwbI

I am thrilled to share with you the outcome of the first collaboration with Albesa-Jove's lab (albesalab.org), in which we characterised the molecular mechanisms underlying the binding of a T6SS adaptor-effector pair in P. putida, Tap3–Tke5. (🧵1/9). Read the full paper here: doi.org/10.1038/s443...