Thanks @cancerdynamics.bsky.social for highlighting this interview with @columbiacancer.bsky.social for Blood Cancer Awareness Month and our work in @cohesinlab

Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome The transcription factor GATA1 has pleiotropic hematopoietic functions, particularly in erythroid and megakaryocytic ontogeny. While mechanistic investigations have uncovered many facets of GATA1 biol...

🚨 Excited to share our new preprint: Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome. This work was led by Columbia VP&S MD student Varun Sudunagunta (‼️ Program Directors: Varun is applying to IM residencies this year!) www.biorxiv.org/content/10.1...

Can’t wait to read it John!

Educational Session: “Dysregulation of nuclear topology in cancer: Clinical implications and emerging mechanisms”
Presenter:
@thedoctorisvin.bsky.social
April 25, 2025, 3:30 PM - 3:50 PM CST/ 4:30 PM - 4:50 PM EST

If you’re at @theaacr.bsky.social don’t miss today’s session on 3D Topology & Cancer featuring giants of the field: Jane Skok @nyulangone.bsky.social & Brad Cairns @utah.edu

Imposter syndrome at an all time high! 😬

Proud to represent @cohesinlab.bsky.social @columbiacancer.bsky.social #AACR25

Cohesin-dependent regulation of Runx genes Runx transcription factors determine cell fate in many lineages. Maintaining balanced levels of Runx proteins is crucial, as deregulated expression leads to cancers and developmental disorders. We con...

And is it just FLI1? We don’t think so! Actually a HUGE part of this mechanism coming into focus was it helps us unify our prior PU.1 finding and may explain your zebrafish runx1 data that has been the inspiration for so much of our work! journals.biologists.com/dev/article/...

Nope! No change in my overall expression by RNA or protein—but a redistribution of the protein towards a much higher chromatin-bound fraction.

And we think this disordering of the FLI1 cistrome is a big part of the mechanism!

Preprint Watch: April Welcome to our monthly Preprint Watch, where we highlight some of the most relevant preprints for the ISEH community! This month we cover so...

Hey! Check out @drjanexu.bsky.social discussing @cohesinlab.bsky.social’s first preprint on @isehsociety.bsky.social simply blood preprint watch! www.simplyblood.org/2025/04/prep...

👇👇 Check out our first pre-print!

@damonrunyon.org @dorisdukefdn.bsky.social @columbiacancer.bsky.social @clevelandclinic.bsky.social @mskcancercenter.bsky.social @euralumni.bsky.social @columbiamed.bsky.social @cohesinlab.bsky.social